Cunto ketogenic ah ayaa dhexdhexaadinaysa saameynta hidaha

Ma jirtaa qayb ka mid ah hidde-sideyaasha xanuunka laba-cirifoodka?

Waxaa hubaal ah in ay jirto qayb ka mid ah hidde-sideyaasha cudurka laba-cirifoodka. Dhaxalka waxa lagu qiyaasaa inta u dhaxaysa 60-85%. Qaar ka mid ah hiddo-wadaha ayaa loo aqoonsaday inay yihiin bartilmaameedyo muhiim u ah faragelinta dawooyinka. Ketones waa dhexdhexaadiyayaal firfircoon qaar ka mid ah dariiqooyinkan hidda-wadaha, ha ahaato muujinta ama muujinta hooska hoose. Cuntooyinka ketogenic ayaa hadda la baarayaa sidii daaweyn loogu talagalay cudurka laba-cirifoodka.

Hordhac

Caadi ahaan, markaan wax ka qoro xanuunka dhimirka iyo isticmaalka cuntada ketogenic ee daaweynta, waxaan diiradda saaraa dhinacyada gulukooska hypometabolism, dheellitirka neurotransmitter, caabuqa, iyo cadaadiska oksida. Laakin markaan samaynayo cilmi-baaristayda boostada blog-ka ee xanuunka laba-cirifoodka, waxaan ku faraxsanahay inaan arko cilmi-baaris badan oo lagu sameeyo hababka hiddaha. Markii aan akhriyay qaar ka mid ah hiddo-wadaha la aqoonsaday, waxaan aqoonsaday qaar badan oo iyaga ka mid ah ama dariiqyada ay saameeyaan inay saameeyaan ketones.

My hidaha biochemistry ma aha waxa aan ugu yeeri karo adag. Laakiin waxaan go'aansaday in sababta oo ah cudurka laba-cirifoodka iyo rabshadaha niyadda ee dambe ayaa la ogaaday inay leeyihiin dhaxal sare, waxaa laga yaabaa inay waxtar leedahay in laga hadlo.

Marka loo eego daraasadaha mataanaha iyo qoyska, dhaxalka BD waxaa lagu qiyaasaa 60-85%.

Mullins, N. iyo al., (2021). Daraasadda ururka guud ee genome ee in ka badan 40,000 xaaladood oo laba-cirifoodka ah ayaa bixisa fikrado cusub oo ku saabsan bayolojiga hoose.
https://doi.org/10.1038/s41588-021-00857-4

Maxay tahay sababta aan u rabo inaan ka hadlo saameynta hidde-sideyaasha ee cudurka laba-cirifoodka?

Sababtoo ah mararka qaarkood marka naloo sheego in jirradeenna maskaxdu ay tahay hidde, waxaan dareemeynaa inaanan awood u lahayn inaan beddelno calaamadaha. Oo haddii aan awoodo inaan ku qanciyo inay jiraan wax aad awoodid inaad sameyso si aad u dhexdhexaadiso qaar ka mid ah muujinta hidda-wadaha ee la ogaaday inay aad ugu xidhan yihiin xanuunka laba-cirifoodka, waxay ku siin kartaa xoogaa rajo ah inaad dareento fiicnaan.

Waan ogahay in haddii aad qabtid cudurka laba-cirifoodka oo aad akhrinayso boostada blog, waxaad noqon kartaa mid ka mid ah saddex-meelood laba-meelood laba ee bukaannada BPD, kuwaas oo, inta la daaweeyay, ay weli qabaan calaamadaha prodromal iyo xitaa niyad-jabka episodic. Sidaas darteed, sababtoo ah waxaan rabaa inaad ogaato dhammaan siyaabaha aad ku dareemi karto fiicnaan, waxaan kula wadaagi doonaa waxaan bartay.

Markaad hoos akhrido, maskaxda ku hay in maskaxda laba-cirifoodka ay la halgameyso heerarka sare ee caabuqa iyo walbahaarka oksaydhka, tamarta maskaxda (glucose hypometabolism), iyo isu dheelitir la'aanta neurotransmitter. Tani waxay kaa caawin doontaa inaad fahamto sida cuntada ketogenic iyo saamaynta ay ku leedahay calaamadaynta hidda-socodka iyo faa'iidooyinka faa'iido leh ee hoos u dhaca ayaa laga yaabaa inay bixiyaan ikhtiyaar daaweyn oo waxtar leh.

Hidde-sideyaasha, ketones iyo xanuunka laba-cirifoodka

Waa arrin aad u xiiso badan in la ogaado, in hiddo-wadaha ku xiran BPD la helo oo la aqoonsado mar kasta. Afar ka mid ah bartilmaameedyada ugu rajo-gelinta badan ee horumarinta daroogada cusub ee BPD waxaa saameeya β-Hydroxybutyrate ama unugyada kale ee ketone. Waxayna sidaas oo kale dhacda in ketones loo soo saaro qayb ka mid ah cuntada ketogenic. Baadhitaan lagu sameeyay suugaanta ayaa muujisay in saameyntu ay tahay mid toos ah ama hoos u socota oo saameeya habka la xidhiidha ee lagu arkay pathology ee xanuunka laba-cirifoodka. Kuwaas waxaa ka mid ah GRIN2A, CACNA1C, SCN2A, iyo HDAC5.

HDAC5

β-Hydroxybutyrate, oo ah jirka ketone, wuxuu yareeyaa saameynta cytotoxic ee cisplatin iyadoo loo marayo firfircoonida HDAC5. Joojinta HDAC5 waxaa lagu muujiyay inay tahay neuroprotective iyadoo la joojinayo waddooyinka apoptosis. Maxay ketones gacan uga geysan la'dahay daawaynta kala duwanaanshaha hidde-sideyaasha HDAC5 iyaga oo keenaya saamaynta neuroprotective? Runtii miyaynu u baahanahay dawooyin cusub si ay u saameeyaan isbedelada HDAC5 si loo daweeyo xanuunka laba-cirifoodka?

Isbeddellada HDAC5 iyo saamaynta neerfaha ee ketones ee waddadan ma noqon karaan mid ka mid ah hababka sameeya daaweynta cuntada ketogenic ee xanuunka laba-cirifoodka? Waxaan filayaa inay noqon karto. Dhammaan kuwan waa su'aalo aan rajaynayo inaan arko doodaha iyo jawaabaha suugaanta cilmi-baarista tobanka sano ee soo socda.

GRIN2A

Marka xigta aan ka wada hadalno hidda-wadaha GRIN2A. Hidde-sidahani waxa uu sameeyaa borotiinka GRIN2A. Borootiinkani waa qayb ka mid ah N-methyl-D-aspartate (NMDA) reseptors (ion channels). Qabayayaasha NMDA waxa lagu xakameeyaa, qayb ahaan, glutamate oo waxay soo diraan calaamado kicinaya maskaxda. Qabayayaasha NMDA waxay ku lug leeyihiin balaastikada synaptik (barashada iyo xusuusta) waxayna door ka ciyaaraan hurdo qoto dheer. Waxaan ku daraa saamaynta ketones ee dariiqa NMDA halkan, badiyaa sababtoo ah soo-dhoweeyayaashu waa kuwo glutamate-habeeya.

Laakiin waxaan si fudud ugu dhejin karaa qaybta caabuqa ama cadaadiska oksida ee qoraalkan. Sababtoo ah marka glutamate uu sarreeyo, badanaa waxaa sabab u ah neuroinflammation oo saameeya wax soo saarka neurotransmitter iyo dheelitirka. Kaliya ogow isku dheelitir la'aanta nidaamyada neurotransmitter (tusaale, heerarka glutamate ee kordhay iyo dhaqdhaqaaqa soo-dhoweynta NMDA; kororka NMDA-excitotoxicity) waxay la xiriiraan cudurka laba-cirifoodka. Ketones waxay si toos ah u dhexdhexaadiyaan caabuqa waxayna saameeyaan wax soo saarka glutamate si bararka hoos loo dhigo oo glutamate lagu sameeyo qiyaasta saxda ah iyo saamiga.

SCN2A

SCN2A waa hidde-sidaha bixiya tilmaamo samaynta borotiinka kanaalka soodiyamka ee loo yaqaan NaV1.2. Borootiinkani waxa uu u ogolaadaa neurons-ku in ay wada xidhiidhaan iyaga oo isticmaalaya calaamadaha korantada ee loo yaqaan awooda waxqabadka. Cuntooyinka ketogenic ayaa muddo dheer loo isticmaali jiray daaweynta suuxdinta waxaana si gaar ah loo isticmaalaa in lagu daweeyo kuwa leh isbeddellada hidde-sidaha gaarka ah ee SCN2A. Ma aaminsani in ay tahay fidno aan macquul ahayn in la qiyaaso in cuntooyinka ketogenic laga yaabo inay gacan ka geystaan ​​daaweynta kala duwanaanshaha hidda-socodka ee SCN2A ee aan ku aragno dadka laba-cirifoodka ah.

CACNA1C

CACNA1C waxa kale oo loo aqoonsaday inuu xidhiidh adag la leeyahay xanuunka laba-cirifoodka. Waxa kale oo ay saamaysaa kanaalada calcium-ku-tiirsanaanta danab, kuwaas oo muhiim u ah shaqada xuubka ee neerfaha. Waxaad u baahan tahay xuubabka unugyada neerfaha ee caafimaad qaba si aad u xaqiijiso yoolalka muhiimka ah sida kaydinta nafaqeynta, wax soo saarka neurotransmitter, iyo xiriirka ka dhexeeya unugyada.

CACNA1C waa qalab ku jira subunit alpha1 channel calcium. Inkastoo heerkayga hadda ee biochemistry-ga hidde-sidaha uusan ii oggolaan inaan si qumman u raadiyo waddadan, waxaan ogahay in wax loo yaqaan 'paroxysmal depolarization shifts' (PDS) loo maleynayo inay ku lug leeyihiin suuxdinta suuxdinta. Cuntooyinka ketogenic waxay u muuqdaan inay dejiyaan isbeddellada depolarization ee dadka qaba qalalka, tanina waxaa loo maleynayaa inay tahay mid ka mid ah hababka ay cuntooyinka ketogenic uga shaqeeyaan dadkan. Iyo shaqada, waxaan ula jeedaa macno ahaan yare oo marmar jooji suuxdinta.

Dib u hagaajinta iyo xasilinta xuubka waxay sidoo kale u dhici kartaa si aan toos ahayn iyada oo la kordhinayo tamarta unugyada iyo ka gudubka dheef-shiid kiimikaadka maskaxda oo aan shaqaynayn. Ketones ayaa bixiya isha tamarta la hagaajiyay, sidaas awgeed ketones laga yaabo inaysan si toos ah u saameynin muujinta dariiqa CACNA1C, waxay ku siin karaan daawada saameynta CACNA1C snip ee saameeya calaamadaha laba-cirifoodka.

Xanuunada suuxdinta ayaa lagu daweeyay iyadoo la adeegsanayo cuntada ketogenic ilaa 1920-meeyadii, saameynahaasna si wanaagsan ayaa loo diiwaangeliyay oo aan la diidi karin xilligan. Saamaynta ketones ee kanaalada kaalshiyamka iyo dib-u-soo-celinta xuubka neerfaha ayaa si fiican loo diiwaangeliyay suugaanta suuxdinta.

Laakiin ujeedkaygu waa in cuntooyinka ketogenic ay daaweeyaan cilladda kanaalka kaalshiyamka waxayna hagaajiyaan caafimaadka xuubabka neerfaha iyo shaqada. Haddaba maxay u shaqayn wayday in la caawiyo kuwa qaba xanuunka laba-cirifoodka? Tani miyaanay noqon karin hab kale oo ay cuntada ketogenic ka caawin karto yaraynta calaamadaha laba-cirifoodka?

Ugu Dambeyn

Kuwani waa tusaalooyin hiddo-wadaha loo aqoonsaday inay saameyn ku leeyihiin habka cudurka ee cudurka laba-cirifoodka, oo laga yaabo in lagu xakameeyo ficilka ketones si toos ah ama hoos u ah alaabta noolaha firfircoon ee la sameeyay iyo sida loo isticmaalo. Marka iyada oo ay jirto qayb muhiim ah oo ka mid ah hidde-sideyaasha xanuunka laba-cirifoodka, waxaa sidoo kale jira siyaabo lagu saameeyo hidde-sidayaashaas iyo sida loo muujiyo, wax ka beddelka sida loogu muujiyo waddooyinka muhiimka ah.

Waxaa muhiim ii ah inaad taqaan dhammaan siyaabaha aad ku dareemi karto fiicnaansho, iyo inaad fahamto in shay uu yahay hidde-side, macnaheedu maaha inaadan qaar ka mid ah hidde-sidayaashaas ka shidin karin kana saari karin qaab nololeedkaaga ama arrimo kale. micneheeduna maaha in hidde-sidayaashaadu ay aayahooda ka taliyaan marka ay timaaddo jirro dabadheeraad ah - xitaa jirro maskaxeed oo daba-dheer, sida xanuunka laba-cirifoodka.

Laba-cirifoodka (BD) waa xanuun maskaxeed oo daran oo lagu garto xaalad maskaxeed iyo niyad-jab oo soo noqnoqda. Marka laga soo tago arrimaha hiddaha, isdhexgalka hidda-socodyada deegaanka ee adag, kaas oo beddela heerka epigenetic ee maskaxda, gacan ka geysta etiology iyo pathophysiology ee BD.

(xoog la saaray) Sugawara, H., Bundo, M., Kasahara, T. al et., (2022). https://doi.org/10.1186/s13041-021-00894-4

Cuntada Ketogenic ee Cudurka Laba-cirifoodka

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Cuntada Ketogenic waxay daaweysaa khamriga

Daaweeyahaaga caafimaadka dhimirka miyuu ka yaqaan keto?

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