Cuntada ketogenic ma daweyn kartaa xanuunka laba-cirifoodka?

Caddaynta kor u kaca waxay taageertaa isticmaalka cuntooyinka ketogenic ee xanuunka laba-cirifoodka sababtoo ah awoodda cuntada ketogenic si ay wax uga beddesho hababka pathological ee hoose sida hypometabolism maskaxda, dheellitir la'aanta neurotransmitter, bararka maskaxda, iyo cadaadiska oksida. Waxaa jira warbixino badan oo anecdotal ah, daraasado kiis oo la daabacay oo lagu daabacay joornaalada dib-u-eegis ee asxaabta, maqaallada dib u eegista suugaanta mawduuca, iyo tijaabooyin la xakameynayo oo la xakameynayo oo lagu qiimeeyo cuntada ketogenic sida daaweynta xanuunka laba-cirifoodka.

Hordhac

Dhacdooyinka maskaxda ee BPD guud ahaan waxaa loo tixgeliyaa in si cadaalad ah si wanaagsan loo maareeyay daawooyinka. Laakiin xaaladaha waaweyn ee niyad-jabka ayaa weli loo arkaa inay yihiin kuwo soo noqnoqda iyo caqabad caafimaad oo muhiim ah. Dadka qaba xanuunka laba-cirifoodka waxay la ildaran yihiin culeyska calaamadaha niyad-jabka ee muhiimka ah, xitaa kuwa xanuunka maskaxdooda ay dareemaan in si fiican loo xakameeyey dawooyinka.

Marxaladani waxay abuuri karaan naafo shaqayn joogto ah iyo naafo waxayna kordhin karaan halista is-dilitaanka. Ku-tiirsanaanta daawooyinka aan waxtarka lahayn si loo daweeyo wejiyada niyad-jabka ee xanuunka laba-cirifoodka waa labadaba naxariis iyo khatar. Xitaa haddii ay tahay heerka daryeelka. Dejinta niyadda hadda jirta ee marxaladda niyad-jabka ee xanuunka laba-cirifoodka ayaa kaliya waxtar u leh 1/3 ee bukaannada laba-cirifoodka ah iyo kuwa caadiga ah ee ka-hortagga niyad-jabka si isdaba-joog ah ugu guuldareystaan ​​inay muujiyaan faa'iidada RCT-yada xaaladdan oo laga yaabo inay xitaa ka sii darto xaaladda. Daawooyinka xanuunka dhimirka ee aan caadiga ahayn ayaa lagu soo waramayaa inay aad waxtar u leeyihiin laakiin waxay leeyihiin saameyn xun oo dheef-shiid kiimikaad taasoo ka dhigaysa isticmaalka muddada dheer mid aan caafimaad qabin iyo waxyeellooyin inta badan aan loo dulqaadan karin bukaanka.

Waxaan u qoraya korka si aan u muujiyo dhibaatada dad badan oo la ildaran xanuunka laba-cirifoodka, iyo in aan tilmaamo in xitaa haddii qof qaba xanuunka laba-cirifoodka uu helay calaamadihiisa manic ee lagu xakameynayo dawo (kuwo badan ayaan haysan), waxaa weli jira qayb muhiim ah oo ka mid ah laba-cirifoodka. dadka qaba calaamadaha haraaga ah.

Waxayna mudan yihiin inay ogaadaan dhammaan siyaabaha ay ku dareemi karaan fiicnaan.

Dhowr habab oo bayooloji ah ayaa la soo jeediyay inay yihiin sababaha asaasiga ah ee BD. Kuwaas waxaa ka mid ah cilladda mitochondrial, walbahaarka oksaydhka iyo carqaladaynta neurotransmitter.

Yu, B., Ozveren, R., & Dalai, SS (2021). Cunto ketogenic ah sida daaweynta dheef-shiid kiimikaad ee xanuunka laba-cirifoodka: Horumarrada kiliinikada. https://www.researchsquare.com/article/rs-334453/v2

Marka aan ka wada hadalno gulukooska hypometabolism, isu dheelitir la'aanta neurotransmitter, caabuqa, walbahaarka oksida, iyo sida cuntada ketogenic wax uga beddesho arrimahaas, waxaad bilaabi doontaa inaad fahamto sababta ay dadku u sameynayaan cuntada ketogenic ee xanuunka laba-cirifoodka.

Aynu bilowno!

Laba-cirifoodka iyo Hypometabolism

Cudurada dheef-shiid kiimikaad ee aasaasiga ah ee loo maleeyo inay door ka ciyaaraan waxaa ka mid ah cillad la'aanta dheef-shiid kiimikaadka tamarta.

Yu, B., Ozveren, R., & Dalai, SS (2021). Isticmaalka karbohaydrayt hooseeya, cuntada ketogenic ee xanuunka laba-cirifoodka: dib u eegis nidaamsan. https://www.researchsquare.com/article/rs-334453/v1

Waa maxay hypometabolism maskaxda? Dadka qaba xanuunka laba-cirifoodka ma leeyihiin hypometabolism?

Maskaxda hypometabolism waxay si fudud ula macno tahay in unugyada maskaxdu aanay si fiican u isticmaalin tamar qaybaha maskaxda qaarkood ama dhismayaal gaar ah. 

• hypo = hoose
• dheef-shiid kiimikaad = isticmaalka tamarta

Dadka qaba xanuunka laba-cirifoodka waxay leeyihiin gobollo maskaxeed oo hypometabolism ah, taasoo la micno ah in meelaha maskaxdu aanay u firfircoonayn sidii la rabay. Hypometabolism maskaxdu waxay runtii ku saabsan tahay cilladda mitochondrial, taas oo asal ahaan ah sida maskaxdu u isticmaasho shidaalka iyo sida ugu wanaagsan ee ay u soo saarto tamarta.

Ma aha oo kaliya hal aag gaar ah oo maskaxda ah oo aan ku aragno cillad la'aanta mitochondrial ee urursan oo u ciyaara sida tamarta yaraanta. Qaar ka mid ah aagagga maskaxda ee loo aqoonsaday inay yihiin hypometabolic iyada oo loo marayo tignoolajiyada neuroimaging ee kala duwan waxaa ka mid ah insula, lafaha maskaxda, iyo cerebellum.

Waxa kale oo jira caddayn ku filan hypometabolism oo keenaysa isku xidhka khalkhalka gudaha walaxda cad ee hore. Carqaladeyntan qaabdhismeedka unugyada iyo dheef-shiid kiimikaadka ayaa si qoto dheer uga dhex dhaca maadada cad ee maskaxda ee u dhaxaysa shabakada hore-limbic. Kuwa ku cusub dhammaan magacyada qaab dhismeedka maskaxda, nidaamkaaga limbic waa xarunta dareenka maskaxda. Laakiin waxaa muhiim ah in la fahmo in shucuurtaadu ay ka iman karto qiimeyntaada xaalad (Oh taasi waa shabeel oo ay dadka cunaan!) iyo in farriintaasi ay ku socoto nidaamkaaga limbic si aad u bilowdo jawaabta (RUN!). Cudurka laba-cirifoodka, waxaan ku aragnaa dhibaatooyinka isku xirnaanta walxaha cad ee shabakadaha garashada ee waaweyn oo ay ku jiraan kiliyaha hore ee dorsolateral, gobollada ku meel gaarka iyo parietal. Kuwaas oo asal ahaan ah dhammaan qaybaha aadka muhiimka ah ee aad u baahan tahay si aad u shaqeyso oo aad si fiican ugu gubto tamarta.

Meelahan la aqoonsaday ee qaab dhismeedka maskaxda hypometabolism maaha wax la yaab leh markaan ka fikirno muujinta calaamadaha saameeya iyo dabeecadda ee xanuunka laba-cirifoodka. Tusaale ahaan:

• khalkhalka u dhexeeya kortex cingulate dorsal, iyo precuneus, cuneus.
  • Waxaa loo malaynayaa in xidhiidhkan go'ay uu door ka ciyaari karo kuwa xiga falcelin xad-dhaaf ah inta lagu guda jiro habaynta dareenka ee bukaanka laba-cirifoodka
• cortex horay gumeysi hore
  • waxay xakameysaa hawlaha fulinta sida qorshaynta hawlaha, xusuusta shaqada, iyo feejignaanta xulashada.
• kortex xingulate dorsal
  • xakamaynta fulinta (oo aad u baahan tahay si aad u dejiso shucuurta), barashada, iyo is-xakamaynta.
  • hypometabolism ee kortex cingulate ayaa lagu arkaa shakhsiyaadka qaba cilladaha isticmaalka muqaadaraadka
• precuneus
  • aragtida deegaanka, falcelinta tilmaanta, xeeladaha sawirka maskaxda, xusuustii episodic dib u soo celinta, iyo jawaabaha saamaynta leh ee xanuunka.

Laakiin sug hal daqiiqo, waxaad odhan kartaa. Dhaqdhaqaaq badan? Sidee taasi ku dhici kartaa maskaxda oo leh hypometabolism marka aan fileyno inaan tamar ku filan u lahayn dhaqdhaqaaqa dheeraadka ah inuu dhaco? Sidoo kale, miyaanay wejiyada qaar ee xanuunka laba-cirifoodka ka dhigayn qof walba nooc kacsanaan ah? Sida inayan joojin karin ama seexan karin? Sidee tani u khusaysaa?

Hagaag, jawaabtu waa mid is barbar dhig ah. Marka meelaha maskaxda qaarkood aysan haysan tamar ku filan oo ay ku shaqeeyaan, waxay keeni kartaa saameynaha hoose ee carqaladeeya dheellitirka neerfaha ee gobollada kale. Markaa hypometabolism ee qaybo ka mid ah maskaxdu waxay ka tuurtaa nidaamka jilicsan ee maskaxda, waxayna ku dhammaataa dheelitir la'aanta neurotransmitter dhammaan ama dhismayaasha deriska ah, taasoo keenta hyperexcitability heerka neurotransmitter. kuwaas oo aan qaybo dambe uga hadli doono (fiiri Isku-dheellitir la'aanta Neurotransmitter). Hypometabolism ee meel ka mid ah maskaxda waxay keeni kartaa in maskaxdu ay xiriir aad u badan la sameyso qaybaha kale ee maskaxda, isku dayaysa inay magdhowdo. Waxaad ku dhamayn kartaa isku xidhka meelaha aan runtii ka tirsanayn oo aad isugu xidhan.

Awood la'aanta unugyada maskaxda si ay u helaan tamar ku filan oo ka timaada isha shidaalka deggan waxay sii waddaa cillad la'aanta mitochondrial. Mitochondria waa baytariyada unugyadaada, waxaana loo baahan yahay si ay u gutaan dhammaan waxyaabaha uu neuronku u baahan yahay inuu sameeyo. Haddii shidaalka maskaxdaadu aanu kuu shaqaynayn, taas oo marka laga hadlayo gulukoosta iyo xanuunka laba-cirifoodka laga yaabo inay si fiican u dhacdo, baytariyadu ma shaqayn karaan. Neurons-yadu ma haystaan ​​tamar ku filan oo ay ku shaqeeyaan waxayna bilaabaan inay si sax ah u shaqeeyaan! Neuron-ka cilladaysani ma awoodo inuu sameeyo ilaalinta aasaasiga ah ee unugyada, sameeyo neurotransmitters, ama xitaa ku hay kuwa neurotransmitters agagaarka wakhtiga saxda ah ee synapse, ama xitaa awood u leh inay si fiican ula xiriiraan unugyada kale.

Sababtoo ah waxay ku jiraan cidhiidhi, waxay abuuraan heerkooda caabuqa iyo oksaydhka, iyaga oo isticmaalaya cofactors qaali ah (fiitamiino iyo macdan) isku dayaya inay la dagaallamaan caabuqa dhacaya sababtoo ah unuggu wuxuu ku dhibtoonayaa tamar yaraan. Hoos u dhigista unugyada oo ku daraya wareegga tamarta liidata ee neuron-ka.  

Mid ka mid ah aragtiyaha sababta tani u dhacdo ayaa ah in dheef-shiid kiimikaadka gulukoosku uu daciifo maskaxda sababtoo ah beddelka liidata ee enzyme muhiim ah oo loo yaqaanno pyruvate dehydrogenase complex (PDC). Dhibaatooyinka u beddelka gulukoosta ilaha tamarta ee maskaxda waxay leeyihiin cawaaqib xun.

Hypometabolism-kan, iyo cillad la'aanta mitochondrial ee soo socota, ayaa si aad ah ugu habboon maskaxda laba-cirifoodka, in cilmi-baarayaashu ay samayn karaan jiirarka transgenic oo leh cillad maskaxeed oo gaar ah, oo gebi ahaanba dib u abuurto calaamadaha uu la kulmo aadanaha laba-cirifoodka ah!

Iyo, marka ay ku daaweeyaan jiirarka transgenic leh lithium ama xitaa dawooyinka niyad-jabka caadiga ah, waxay uga jawaabaan si la mid ah sida bukaanada laba-cirifoodka ee bini-aadmiga ay ku sameeyaan daawooyinkaas.

Markaa ujeedkaygu waa kan. Hypometabolism waa arrin aad u weyn oo ku jirta abuurista iyo jiritaanka calaamadaha laba-cirifoodka. Waxay u qalantaa fiiro gaar ah sida bartilmaameed toos ah ee faragelinta xanuunka laba-cirifoodka.

Hadda, aan ka wada hadalno sida cunto ketogenic ah, oo ah daawaynta caanka ah ee cilladaha dheef-shiid kiimikaadka, ay u caawin karto.

Sida keto u daweeyo hypometabolism ee xanuunka laba-cirifoodka

Cuntooyinka ketogenic waa saaxiibka ugu fiican ee neerfaha. Ma aha oo kaliya inay bixiyaan ilo kale oo shidaal ah oo gulukoos ah qaabka ketones, tamarta ketone waxay si toos ah ugu dhacdaa neerfaha, iyada oo ka gudubta hababka enzyme gaarka ah ama hawlaha gaadiidka khaldan. Dheef-shiid kiimikaadka tamarta ee la roonaaday wuxuu siinayaa maskaxda laba-cirifoodka tamarta si ay u qabato dhammaan waxyaabaha ay u baahan tahay, si ka fiican sidii ay markii hore ahayd.

Sida haddii lahaanshaha il shidaal oo wanaagsan oo maskaxdu ay si ka wanaagsan u isticmaali karto aysan ku filneyn, ketones laftooda ayaa ah jirka calaamadaha hidda-wadaha. Tani waxay la macno tahay inay u rogi karaan oo ay dami karaan hiddo-wadaha waddooyin kala duwan. Mid ka mid ah waxyaabaha ay ketonesku sameeyaan ayaa ah inay ku dhiirigeliyaan unugga inuu sameeyo mitochondria badan. Ketones run ahaantii waxay kordhiyaan tamarta maskaxda iyaga oo samaynaya wax badan oo ka mid ah baytariyada unugyada ka dibna siiya shidaalka si ay ugu gubaan iyaga.

Haddii aadan weli ku qanacsanayn in cunto ketogenic ah loo tixgeliyo daaweynta hypometabolism ee lagu arkay xanuunka laba-cirifoodka, waxaa laga yaabaa inay faa'iido kuu yeelato inaad wax ka barato sida qaar ka mid ah calaamadaha xanuunka laba-cirifoodka ay la mid yihiin waxa aan ku aragno cudurrada neurodegenerative.

Qaabka hypometabolism ee maskaxda ee xanuunka laba-cirifoodka, ayaa aad ula mid ah cudurka Alzheimers, in bukaannada da'da weyni ogaanshaha kala duwanaanshiyaha ay tahay mid aad u adag oo mararka qaarkood suurtagal maaha.

Natiijooyinkayagu waxay daaha ka qaadayaan astaamaha neurocognitive-ka caadiga ah ee bukaannada laba-cirifoodka leh ee leh cillad garasho ee laga shakisan yahay asalka neerfayaasha waxay soo jeedinayaan ka qaybqaadashada cuduro kala duwan oo hoose…

Musat, EM, iyo al., (2021). Astaamaha Bukaan-socodka Laba-cirifoodka leh ee garashadoodu liidato ee Asal ahaan Neurodegenerative la tuhunsan yahay: Koox-kooxeedyo badan. https://doi.org/10.3390/jpm11111183

Dhab ahaantii, xanuunka laba-cirifoodka wuxuu leeyahay waxyaabo badan oo aan caadi ahayn oo isku mid ah, labadaba dheef-shiid kiimikaadka maskaxda iyo dariiqyada calaamadaha sida cudurro badan oo neerfaha ah, oo ay ku jiraan cudurka Alzheimers (AD), Lewy Body Dementia, iyo xitaa qaybo ka mid ah cudurka Parkinson.

Cuntooyinka ketogenic waa daaweyn caddayn ku salaysan oo loogu talagalay cudurka Alzheimers, oo leh dhowr RCTs oo muujinaya faa'iidooyin. Maxay u caawin weyday isla isla gobollada maskaxda ee la halgamaya tamarta iyo dheef-shiid kiimikaadka? Gaar ahaan markaan arki karno in qaar badan oo ka mid ah isla gobollada maskaxda ay ku lug leeyihiin.

Sideen ku ogaan karnaa tan? Miyaynu haynaa daraasadaha sawir-qaadista maskaxda ee RCT oo weli muujinaya waxqabadka maskaxda ee soo fiicnaaday gaar ahaan dadka qaba xanuunka laba-cirifoodka ee qaata cunto ketogenic ah? Ma aha in aan helay. Laakiin waxaan hubaa inay imanayaan. Sababtoo ah waxaan aragnaa hoos u dhac weyn oo calaamadaha dad badan oo qaba xanuunka laba-cirifoodka ee u guura cuntada ketogenic. Qaar ka mid ah calaamadahaas dhimista waxay si liidata uga imanaysaa tamarta maskaxda oo hagaagtay.

Cunto ketogenic ah waxay u ogolaataa maskaxda laba-cirifoodka inay kor u qaaddo ketones shidaalka oo ay u isticmaasho halkii ay ugu horrayn gulukoosta shidaalka u isticmaali lahayd. Shidaalkan la kordhiyey waa habka samatabbixinta dheef-shiid kiimikaadka maskaxda. Oggolaanshaha tamar badan oo unuggu wuxuu u oggolaanayaa dayactirka unugyada, dayactirka, gudbinta neuron-ka oo wanaajiyey, awoodo waxqabad oo wanaagsan, adigu magacaw. Maskaxdaadu waxay u baahan tahay tamar ku filan si ay u qabato.

Waxaa jira bar macaan mustaqbalka cilmi-baarista si ay u jeexjeexo xiriirka dheef-shiid kiimikaad ee hababka kala duwan ee neurotransmitter. Markaa inta cilmi-baadhistaas laga samaynayo, waa in aan mid walba qaybo gaar ah uga doodno. Waa markii laga guuri lahaa hypometabolism loona gudbi lahaa dheellitir la'aanta neurotransmitter.

Cudurka laba-cirifoodka iyo isku-dheellitir la'aanta neurotransmitter

Waxaa jira noocyo badan oo kiimikooyin neurotransmitter ah oo maskaxda ku jira. Neurotransmitters-ka ku lug leh jirrooyinka laba-cirifoodka waxaa ka mid ah dopamine, norepinephrine, serotonin, GABA (gamma-aminobutyrate), iyo glutamate. Acetylcholine sidoo kale waa lagu lug leeyahay laakiin dib looma eegi doono boostada blog. Marka aan ka hadalno isku dheelitir la'aanta neurotransmitter, waxaa muhiim ah in la fahmo in aynaan ka hadlayn wax aad u badan ama aad u yar mid kasta oo gaar ah. 

Taasi waxay noqon kartaa xaalad ilaa xad, iyada oo samaynta mid ka yar iyo ka badan oo kale ayaa waxtar leh. Laakiin waxa aan ka hadlaynaa waa sida loo sameeyo oo loo isticmaalo neurotransmitters. Reseptors-yada ma loogu talagalay inay ku qaadaan neurotransmitters unugyada si fiican u shaqeynaya? Xuubka unuggu ma ka qaban karaa qaybtiisa samaynta neurotransmitter-ka ama kaydinta nafaqooyinka uu u baahan yahay si uu u sameeyo neurotransmitters? 

Ma jiraan daaweeyayaal aad u badan oo loogu talagalay hal nooc oo neurotransmitter ah? Hadday sidaas tahay, maxay taasi ka dhigan tahay ilaa inta neurotransmitter-ku uu ku sii jiro agagaarka synapse si uu faa'iido u yeesho? Ma jiraan polymorphisms hidde ah oo saameeya enzymes-ka loo maleynayo inay sameeyaan neurotransmitters ama qabtaan shaqada dib u soo celinta?

Waad heshay fikradda. Ujeedadaydu waa marka aan hoos uga hadlo neurotransmitters gaar ah, waxaan wax ka qorayaa nidaam adag. Fikirka nadaamku wuxuu qaataa isbeddel dhinaca aragtida ah. Markaa taas maskaxda ku hay markaad akhrinayso isku dheelitir la'aanta neurotransmitter ee xanuunka laba-cirifoodka.

Nidaamka Dopaminergic

Dopamine (DA) reseptor-ka iyo cilladaha gaadiidleyda ayaa door muhiim ah ka ciyaara pathophysiology ee xanuunka laba-cirifoodka ee labadaba manic iyo niyad-jabka labadaba.
Hal natiijo oo joogto ah ayaa ka timid dopaminergic agonists ee daraasadaha cilmi-baarista. Dopaminergic agonists waxay xannibaan daaweeyayaasha dopamine, sidaa darteed dopamine waxay sii joogi doontaa firfircoonida synapse waqti dheer waxayna bixisaa saameyn la taaban karo. Marka cilmi-baarayaashu ay tan sameeyaan, waxay la jaanqaadi karaan marxaladaha waallida ama hypomania ee bukaannada laba-cirifoodka ah, ama xitaa kuwa kaliya ee leh cillad hoose si ay u qaadaan cudurka.

Daraasadaha qaarkood waxay ogaadeen in bukaannada laba-cirifoodka ah ay leeyihiin firfircoonida nidaamka dopaminergic sare iyo in hawshani ay sabab u tahay sii-deynta sii-deynta neurotransmitter-ka oo kordhay iyo dhibaatooyinka lagu maareynayo hawlaha synaptik. Arrimahan ayaa laga yaabaa inay la xiriiraan horumarinta calaamadaha manic ee bukaannada laba-cirifoodka. Waxaana muhiim ah in la ogaado in heerarka korodhay ee dopamine ay la xiriirto korodhka cadaadiska oksaydhka. Inkastoo tani aysan ahayn qaybta cadaadiska oksaydhka ee blog-ka, cadaadiska oksaydhiyuhu wuxuu aad ugu habboon yahay nidaamka neurotransmitter. Waxay faragelisaa hababka enzymatic ee muhiimka ah waxayna abuurtaa noocyo badan oo oksijiin ah, taasina waxay carqaladaynaysaa deegaanka ay dareemayaashu isku dayayaan in la sameeyo, oo leh saameyno hoose oo muhiim ah.

Nidaamka Norepinephrinergic

Norepinephrine waa neurotransmitter muhiimka ah ee xanuunka laba-cirifoodka. Dopamine waxaa loo beddelaa norepinephrine iyadoo la adeegsanayo enzyme Dopamine-β-hydroxylase (DβH). Marka ay yaraato hawshan ensaymes-ka ah, oo sidaas awgeed dopamine yar loo beddelo norepinephrine, ka-qaybgalayaasha daraasaddu waxay soo sheegaan calaamadaha laba-cirifoodka sare ee liiska hubinta.

MHPG, oo ah wax soo saar uu sameeyay habka dheef-shiid kiimikaad ee abuurista norepinephrine (loo yaqaan metabolite), ayaa loo arkaa inay tahay biomarker suurtagal ah oo lagu aqoonsan karo xaaladaha niyadda. Dheef-shiid kiimikaadkaan waxaa loo soo jeediyay inuu matalo astaamaha bukaan-socodka sida bukaan-jiifka laba-cirifoodka uu u kala beddelo xaaladaha niyad-jabka iyo maskaxda. Oo marka lithium la isticmaalo, waxaa jira hoos u dhac ku yimaadda isla kan kale ee biomarker.

Dhaqdhaqaaqa Norepinephrine wuxuu u muuqdaa inuu isbeddelayo iyadoo lagu saleynayo marxaladda laba-cirifoodka. Heerarka hoose ee norepinephrine iyo soo-dhoweeyaha (a2) dareenka ayaa la soo warramey inta lagu jiro xaaladaha niyad-jabka ah iyo dhaqdhaqaaqa sare inta lagu jiro marxaladaha manic.

Nidaamka Glutamatergic

Glutamate waa neurotransmitter kacsan oo leh doorar badan oo kakan oo muhiim ah. Waxaan ku aragnaa xaddi sare oo firfircoonida glutamate ee xanuunka laba-cirifoodka.

Waxaad rabtaa xoogaa glutamate ah, laakiin aad uma badna, waxaadna dooneysaa uruurin sare meelaha saxda ah. Marka xaaladuhu aysan ku fiicnayn maskaxda, sabab kasta ha noqotee, laakiin waxay u badan tahay inay sabab u tahay bararka (sida aad wax uga baran doonto gadaal), maskaxdu waxay sameyn doontaa glutamate aad u badan (ilaa 100x in ka badan heerarka caadiga ah). Glutamate ee heerarkan waa neurotoxic waxayna sababtaa gabowga neurodegenerative. glutamate aad u badan ayaa dhaawac u geysta neerfayaasha iyo synapses waxayna abuurtaa dhaawac ay tahay in maskaxdu ay markaas isku daydo inay bogsato (iyo culayska shaqada ee dayactirka burburku ma awoodi doono inuu la socdo marka glutamate sare uu yahay mid dabadheeraad ah).

Daraasaduhu waxay si joogto ah u muujinayaan hoos u dhaca muujinta molecules ee ku lug leh gudbinta glutamate ee u dhaxaysa neerfayaasha maskaxda ee dadka qaba xanuunka laba-cirifoodka. Hal mala awaal ayaa ah in xad-dhaafka joogtada ah ee glutamate ee maskaxda ee bukaannada cudurka laba-cirifoodka ay beddelaan qaboojiyeyaasha si ay u yareeyaan waxyeelada.

Glutamate waa neurotransmitter saameynaya niyadda. Waxaan ku aragnaa heerarka glutamate-ka sare ee jirrooyinka dhimirka, sida walaaca, xanuunka xanuunka, PTSD, iyo xanuunka laba-cirifoodka maaha mid ka reeban la wadaaga dheelitir la'aanta neurotransmitter-ka caadiga ah. Marka laga reebo laba-cirifoodka, halkii laga abuuri lahaa weerar argagax leh sida laga yaabo in qof qaba walaac guud, glutamate waxaa lagu arki karaa heerar sarreeya, gaar ahaan inta lagu jiro marxaladda manic ee jirrada.

Nidaamka GABAergic

GABA waa neurotransmitter-ka-hortagga ka-hortagga ah ee u shaqeeya sidii biriiga loogu talagalay neurotransmitters-ka firfircoon sida glutamate. GABA waxay ku lug leedahay xanuunka laba-cirifoodka waxayna la xiriirtaa manic iyo dawladaha niyad-jabka ah, iyo xogta caafimaadku waxay tilmaamaysaa in hoos u dhaca hawlaha nidaamka GABA uu la xiriiro niyad-jabka iyo manic. Dhakhaatiirta cilminafsiyeedka ayaa inta badan qori doona dawooyinka beddela GABA sababtoo ah tani waxay u muuqataa inay saameyn ku leedahay niyadda-dejinta xanuunka laba-cirifoodka.

Waxaa jira calaamado hoose oo joogto ah oo GABA ah oo ku jira maskaxda shakhsiyaadka laba-cirifoodka ah, iyadoo tani aysan ahayn mid gaar ah xanuunka laba-cirifoodka oo ay ku dhacdo cudurrada kale ee dhimirka, waa helitaan joogto ah. Isticmaalka daawooyinka lagu beegsanayo nidaamka GABA waxaa loo isticmaalaa in lagu caawiyo daawaynta marxaladda niyad-jabka ee xanuunka laba-cirifoodka. Ururka hidda-socodka iyo daraasadaha dhimashada ka dib labaduba waxay muujinayaan caddaynta cilladaha aan caadiga ahayn ee nidaamka calaamadaynta GABA.

Bukaannada leh hoos u dhac ku yimaadda GABA waxay u muuqdaan inay leeyihiin cillado garasho oo aad u weyn iyo gaar ahaan xakamaynta xakamaynta dabeecadda.

Nidaamka Serotoninergic

Waxaan ognahay in serotonin uu kaalin ka qaato xanuunka laba-cirifoodka. Caddaymaha taageeraya in serotonin (oo sidoo kale loo yaqaan 5-HT) cilladaha ay ku lug leeyihiin waallida iyo in kordhinta ama kor u qaadida serotonin ay leedahay saameyn niyadda-dejinta ayaa lagu sameeyay daraasado kala duwan iyadoo la adeegsanayo calaamado kala duwan (tusaale, depletion tryptophan, postmortem, platelet, iyo neuroendocrine).

Hoos u dhigista sii deynta iyo dhaqdhaqaaqa serotonin waxay la xiriiraan fikradda is-dilka, isku-dayga is-dilka, gardarada, iyo hurdo la'aanta. Waxaa jira dhammaan calaamadaha ay la kulmaan dadka qaba xanuunka laba-cirifoodka. Laakiin sida aan uga hadalnay hordhaca boostada blog, daawooyinka isku dayaya in ay beddelaan nidaamkan inta badan kuma filna yareynta calaamadahan dadkan.

Shaqada xuubabka unugga iyo BDNF

Ma ka hadli kartid dheellitirka neurotransmitter iyada oo aan laga doodin shaqada xuubabka. Sidaad horeba u baratay, unugyadu waxay u baahan yihiin tamar si ay u shidaan awooda ficilka Waxyaabo muhiim ahina waxay dhacaan marka neerfayaasha ay gubaan, sida awoodda lagu xakameynayo uruurinta calcium. Waa inaad haysataa xuubka unug caafimaad qaba si aad u hesho tamar wanaagsan oo aad u xakamayso qadarka macdanta lagama maarmaanka ah ee maskaxdu u baahan tahay si ay u abuurto awood waxqabad, ilaaliso caafimaadka unugyada, kaydiso nafaqooyinka wax soo saarka neurotransmitter iyo shaqada enzyme.

Cudurka laba-cirifoodka, luminta shaqada sodium/potassium iyo luminta dambe ee (sodium) Na+/ (potassium) K+-ATPase Function (hawlaha muhiimka ah ee enzyme si loo abuuro tamar) ayaa dhacda waxayna gacan ka geysataa yaraanta tamarta unugyada. Isbeddellada ka dhalanaya shaqada xuubka waxay saameyn ku yeelan karaan niyad-jabka iyo niyad-jabka ee xanuunka laba-cirifoodka.

Maskax-derived neurotrophic factor (BDNF) waa walax maskaxda lagu sameeyo oo gacan ka geysata hagaajinta unugyada waxayna samaysaa xiriiryo cusub oo barashada iyo ka dhexeeya dhismayaasha maskaxda. Xusuusnow sida aan uga wada hadalnay cilladaha wareegga neerfaha ee arrinta cad? Waxaad u baahan tahay BDNF si ay kaaga caawiso dib u habeynta wax la mid ah. Dadka qaba xanuunka laba-cirifoodka ma haystaan ​​BDNF ku filan si ay si fiican u qabtaan ama ay ula socdaan dayactirka looga baahan yahay xaaladaha xanuunka neerfaha.

Waxaan rajeyneynaa, boostada blog-ka waxay bilaabeysaa inay ka jawaabto su'aasha ah cuntada ketogenic ma daweyn kartaa xanuunka laba-cirifoodka? Waxaad arki kartaa sida saamaynta dheelitirka neurotransmitter ay u sameeyaan daaweynta ketogenic cuntada ee xanuunka laba-cirifoodka.

Sida keto u dheellitirto neurotransmitters

Cuntooyinka ketogenic waxay saameyn toos ah ku leeyihiin dhowr neurotransmitters. Waxaa jira daraasado badan oo muujinaya kororka serotonin iyo GABA, iyo dheellitirka glutamate iyo dopamine. Waxaa jira xoogaa is dhexgalka u dhexeeya cuntooyinka ketogenic iyo norepinephrine oo hadda lagu baarayo cilmi-baarista suuxdinta. Uma muuqato inay saameyn ketones ku leedahay norepinephrine si toos ah, laakiin hoosta marka loo beddelo dopamine.

Cuntooyinka ketogenic waxay dheelli tiraan wax soo saarka neerfayaasha iyo dhaqdhaqaaqa, si aadan u heli doonin mid aad u badan ama mid aad u yar oo mid kale ah, oo aakhirka aad hesho waxyeelo sida aad mararka qaarkood u qaadan doonto daawooyinka.

Kor u qaadista neurotransmitters qaarkood, sida GABA, ayaa iska cad inay faa'iido u leedahay niyadda, kororkeeduna wuxuu ka caawiyaa dheellitirka wax soo saarka glutamate-ka. Tani waxay u badan tahay inay tahay farsamo aan ku aragno niyadda soo hagaagtay ee shakhsiyaadka laba-cirifoodka ah, iyo sidoo kale waxay si toos ah u saameyn kartaa hoos u dhaca dawladaha maskaxda.

Hab kale oo muhiim ah oo aan ku aragno hagaajinta dheelitirka neurotransmitter waa hagaajinta shaqada xuubka unugyada. Cuntooyinka ketogenic waxay xoojiyaan xidhiidhka ka dhexeeya unugyada waxayna caawiyaan nidaaminta qulqulka nafaqeeyayaalka yar yar (xusuusnow sodium, potassium, iyo calcium?) Loo baahan yahay toogashada unugyada. Shaqada xuubabka ee la hagaajiyay waxay sidoo kale ku dhacdaa habka kor u qaadaya (wax badan ka dhigaya) BDNF, markaa unugyada iyo xuubabka unuggu waxay si fiican u awoodaan inay iskood isu hagaajiyaan. Iyo gunno dheeri ah, horumarintan shaqada xuubabka unuggu waxay u oggolaanaysaa xuubka inay kaydiyaan nafaqeeyayaalka yar yar ee muhiimka ah ee loo baahan yahay si ay u soo saaraan neerfayaasha oo ay bilaabaan dayactir (adigoo isticmaalaya saadka dheeriga ah ee BDNF).

Laakiin sida aan hoos ku baran doono, neurotransmitters si fiican looma samayn karo ama xaddi dheellitiran oo jawiga si joogto ah u socda oo lagu xakameynayo caabuq. Oo sidaas daraaddeed waxaan ku soo gabagabeynayaa doodeena ku saabsan neurotransmitters, laakiin kaliya ee la xidhiidha hababka kale ee cudur-sidaha ee ka dhacaya maskaxda laba-cirifoodka, oo ay ku jiraan bararka iyo walbahaarka oksida.

Laba-cirifoodka iyo bararka

Caabuqa waa arrin ka mid ah xanuunka laba-cirifoodka waana qayb muhiim ah oo cilmi-baaris ah oo keligiis ah waxaana loo aqoonsaday habka aasaasiga ah ee jirrada.

• Nafaqo-yaraanta
  • taasoo keentay in unugu uu awoodi waayo inuu ilaaliyo caafimaadka iyo shaqada)
• Fayrasyada iyo bakteeriyada
• Xasaasiyad
  • cunto ama deegaan
• Waxyaabaha sunta ah ee deegaanka
  • wasakhowga, sunta cayayaanka, heribcide, balaastikada, caaryada
• Mindhicirka microbiome
  • korriinka guud ahaan noocyada taban ee abuura oggolaanshaha mindhicirka iyo bararka
• Cuntooyinka caabuqa
  • heerka caadiga ah ee cuntada Maraykanka, karbohaydraytyada aadka loo warshadeeyey, saliidaha warshadaha, sonkorta dhiiga oo aan la xakameynin

Xanuunka neuroinflammation-ka daba-dheeraada waa jawaab-celin difaac ah mid ama dhowr ka mid ah noocyada weerarradan. Jawaabta difaaca jirka waxay keentaa firfircoonida unugyada microglial ka dibna soo saara cytokines bararka, gaar ahaan, TNF-a iyo IL-1β, si loo baabi'iyo waxa loo arko inay khatar yihiin. Laakin marka sidaas la sameeyo, waxaa jira dhaawac loo geystay unugyada ku xeeran ee ka yimaadda cytokines-kan. Maskaxdu waxay markaa u baahan tahay inay dib u hagaajiso, taas oo ay adag tahay in la fuliyo marka uu jiro barar joogto ah oo aan joogsi lahayn.

Hal aragti oo soo jiidasho leh oo ku saabsan calaamadaha niyad-jabka ee lagu arko xanuunka laba-cirifoodka waa inay la xiriiraan xilliyada. Waxaa jira heer sare oo calaamadaha niyad-jabka ah ee cudurka laba-cirifoodka guga. Mid ka mid ah daraasaddan xiisaha leh ayaa lagu ogaaday in calaamadaha niyadjabku ay la xiriiraan calaamadda difaaca jirka ee serum immunoglobulin E. Waxaa loo maleynayaa in guga, sida manka kor u kaco, calaamadaha niyad-jabka ee shakhsiyaadka laba-cirifoodka ah ayaa noqon kara mid ka sii dara sababtoo ah jawaabta cytokine pro-bararka ee ay keento xasaasiyad.

Wax soo saarka microglial ee cytokines bararka ayaa si gaar ah ugu habboon xanuunka laba-cirifoodka sababtoo ah waxay bixiyaan habka sharraxaadda ee calaamadaha aan ku aragno xanuunka laba-cirifoodka. Dhexdhexaadiyeyaasha bararka, sida cytokines, waxay qaabeeyaan gudbinta synaptik iyo xitaa ka saara xiriirka ka dhexeeya unugyada maskaxda (nidaamka caadiga ah ee caadiga ah ee loo yaqaan manjooyin kaas oo ka baxa gacanta neerfaha joogtada ah). Isbeddelladan maskaxdu waxay wiiqaan dareenka, shaqada fulinta (qorshaynta, barashada, xakamaynta dabeecadda iyo dareenka), iyo xusuusta oo yaraada. Hippocampus, oo ah qayb ka mid ah maskaxda oo leh hawlo muhiim u ah samaynta xusuusta, ayaa si gaar ah ugu dhufatay xanuunka neuroinflammation. Soo saarista cytokines bararka ee aan la xakameynin waxay keentaa dhimashada unugyada maskaxda ee dhicisoobay.

Kordhinta wax soo saarka cytokine bararka ayaa door xoog leh ku leh sababta aan u aragno cillad xun oo sii socota ee dadka oo ka badan xiritaanka iyo meelo badan oo cabbir ah. Dhaqdhaqaaqa dheeraadka ah ee unugyada microglial waxay keenaysaa kororka garashada garashada, shaqada si tartiib tartiib ah u sii xumaanaysa, cudurada caafimaadka oo ay ku jiraan jirro dabadheeraad ah, iyo ugu dambeyntii, dhimashada dhicis ee kuwa qaba xanuunka laba-cirifoodka.

Sidaa darteed bararka iyo dhimista bararka, iyo rajada laga qabo hagaajinta sababta asaasiga ah ee caabuqa ee bukaanka shakhsi ahaaneed, waxay noqotaa bartilmaameed aad u muhiim ah oo faragelin ah oo ku saabsan safarkooda fayoobaanta.

Sidee keto u yaraynaysaa bararka

Uma maleynayo in faragelinta ka fiican ee caabuqa ay jirto marka loo eego cuntada ketogenic. Waan ogahay in taasu tahay hadal sare, laakiin ii dulqaado. Cuntooyinka ketogenic waxay abuuraan wax loo yaqaan ketones. Ketones waa jidhka calaamadeeya, taasoo la micno ah inay awoodaan inay la hadlaan hiddo-wadaha. Jidhka Ketone ayaa la arkay inay si dhab ah u damiyaan hiddo-wadaha kuwaas oo qayb ka ah dariiqyada bararka ee daba-dheeraada. Cuntooyinka ketogenic aad bay waxtar ugu leeyihiin bararka waxaana loo isticmaalayaa arthritis-ka iyo xaaladaha kale ee xanuunka daba dheeraada.

Laakiin sug hal daqiiqo, waxaad odhan kartaa, kuwaas maaha xaaladaha caabuqa maskaxda. Kuwaasi waa cudurro bararka durugsan si aan loo tirin. Taabo

Laakiin waxaan ognahay in cuntooyinka ketogenic ay aad ugu fiican yihiin xanuunka neuroinflammation oo aan u isticmaalno dhaawac maskaxeed oo dhaawac ah. Dhaawac maskaxeed oo ba'an ka dib, waxaa jira duufaan weyn oo cytokine ah oo ka jawaabeysa dhaawaca, Jawaabtaani waxay keentaa waxyeello ka badan inta badan weerarka hore. Cuntooyinka ketogenic waxay aamusnaanayaan jawaabtaas Haddii cuntada ketogenic ay dhexdhexaadin karto dhaawaca maskaxda ee xanuunka neuroinflammation, ma arko sababta aysan u noqon doonin doorasho xiddigle ah oo xanuunka laba-cirifoodka ah. Waxaan sidoo kale u isticmaalnaa dhowr cudur oo neurodegenerative sida Alzheimers, cudurka Parkinson, iyo ALS. Dhammaan xaaladaha leh qayb aad u muhiim ah neuroinflammation.

Markaa maxaynaan u isticmaalin cunto ketogenic si fiican loo qaabeeyey, anti-bararka si loo daweeyo hababka bararka hoose ee aan ku aragno xanuunka laba-cirifoodka?

Laba-cirifoodka iyo Cadaadiska Oxidative

Cadaadiska Oxidative waa waxa dhaca marka ay jiraan noocyo badan oo oksijiin fal-celin ah (ROS). ROS way dhacdaa si kasta oo aan samayno. Laakin jirkeenu wuu garanayaa waxa laga sameeyo. Waxaan xitaa haysanaa habab antioxidant-ku-jir ah (oo lagu sameeyay jirkeena) kuwaas oo naga caawinaya inaan la macaamilno oo yareyno dhaawaca noolaanshaha iyo neefsashada, iyo cunista. Laakin dadka qaba xanuunka laba-cirifoodka, nidaamyadan antioxidant si fiican uma shaqeeyaan ama ma sii wadi karaan dhaawaca socda. Oo sidaas daraaddeed, dadka qaba xanuunka laba-cirifoodka, calaamadaha cadaadiska oksaydhiyuhu waxay si joogto ah uga sarreeyaan kantaroolka caadiga ah ee suugaanta cilmi-baarista. Ma aha hal calaamad oo keliya kan si gaar ah u sarreeya; waa qaar badan oo iyaga ka mid ah.

Cadaadiska Oxidative, iyo awood la'aanta jirku inuu si ku filan u demiyo xanuunka neuroinflammation, ayaa mas'uul ka ah gabowga hippocampal ee la soo jeediyay si ay hoos ugu dhigto cilladaha neurocognitive ee lagu arkay bukaannada BD. Cadaadiska Oxidative wuxuu keenaa dardargelinta gabowga maskaxda ee BD wuxuuna xitaa mas'uul ka yahay heerarka sare ee mitochondrial (batariyada unugyada) isbeddellada DNA ee lagu arkay daraasadaha dhimashada ka dib.

Laakiin kaliya siinta dadka qaba xanuunka laba-cirifoodka ee daaweynta antioxidant si loo yareeyo diiqada oksaydhka waxay leedahay natiijooyin isku dhafan, cilmi-baarayaashu waxay aaminsan yihiin in tani ay noqon karto sababtoo ah heerarka cadaadiska oksaydhka ayaa waxaa saameeya cillad maskaxeed. Xusuusnow waxa aan ka baranay hypometabolism maskaxda iyo tamarta yaraanta iyo cillad la'aanta mitochondrial ee aan ku aragno xanuunka laba-cirifoodka? Laba-cirifoodka waa cillad dheef-shiid kiimikaad ee maskaxda, oo ma jiraan tamar ku filan oo ay maskaxdu isticmaasho?

Arrintaas oo kale ayaa laga yaabaa inay mas'uul ka tahay heerarka walbahaarka oksaydhka ee ay arkeen cilmi-baarayaashu. Ugu yaraan qayb ka mid ah kuwa qaba xanuunka laba-cirifoodka iyo walbahaarka oksaydhka.

Iyadoo aan loo eegin haddii ay tahay sababta asaasiga ah ama habka labaad ee pathology ee xanuunka laba-cirifoodka, waxaan ognahay in cadaadiska oksaydhisku uu yahay qalab lagu abuurayo calaamadaha aan ku aragno xanuunka laba-cirifoodka. Sababtaas awgeed, waxaan u baahanahay faragelin si toos ah u yaraynaysa cadaadiska oksaydhka, iyadoo la doorbidayo dhowr habab.

Sidee keto u yaraynaysaa Cadaadiska oksaydhka

Nidaamka aan jeclahay waa nidaamka antioxidant endogenous waa glutathione. Tani waa nidaam aad u awood badan oo ka hortag ah oo cuntooyinka ketogenic ay si dhab ah u hagaajiyaan. Kor u qaadistan glutathione waxay kaa caawinaysaa inaad yarayso walbahaarka oksaydhka, waxaana laga yaabaa inay hagaajiso shaqada iyo caafimaadka maskaxda laba-cirifoodka. Nafaqada la roonaaday ee ku dhacda cunto ketogenic si fiican loo habeeyey ayaa sidoo kale wanaajisa wax soo saarka glutathione. Sidaas ayaa lagu daray gunno.

Laba nooc oo ketones-β-hydroxybutyrate iyo acetoacetate-ayaa lagu helay inay yareeyaan heerarka ROS ee mitochondria neocortical-ka go'doonsan (Maalouf et al., 2007)

Baaritaan dheeraad ah ayaa loo baahan yahay si loo go'aamiyo habab gaar ah oo KD ah oo ku saabsan diiqada oksaydhka iyada oo loo marayo saameynta ROS iyo heerarka antioxidant. Waxay u badan tahay in saameynta ka hortagga bararka ee jirka ketone lagu gaaro saameyn ku yeelashada dariiqooyin kiimikaad oo badan.

Yu, B., Ozveren, R., & Dalai, SS (2021). Cunto ketogenic ah sida daaweynta dheef-shiid kiimikaad ee xanuunka laba-cirifoodka: Horumarrada kiliinikada.
DOI: 10.21203 / rs.3.rs-334453 / v2

Sida xigashada si fiican ula xiriirto, cuntooyinka ketogenic waxay saameeyaan wadooyin badan oo wax ka beddelaya cadaadiska oksaydhka. Jidhka ketone ka sokow, caafimaadka neerfaha ee soo hagaagay ee ku dhaca cuntada ketogenic, sida korodhka BDNF, neurotransmitters dheellitiran oo aan keenin dhaawaca neerfaha (waxaan ku eegayaa adiga, glutamate iyo dopamine!), Iyo xuubabka unugyada shaqada oo caafimaad qaba dhamaantood waxay sameeyaan shaqadooda. qayb ka mid ah dhimista cadaadiska oksaydhka. Taasi waxay wanaajisay awoodda xuubka iyo shaqada, oo ay weheliso qaadashada nafaqo ee la wanaajiyey ee laga helo cunto ketogenic si fiican loo habeeyey, runtii waxay hagaajisaa enzyme iyo soo saarista neurotransmitter, kuwaas oo door ka ciyaara la dagaallanka diiqada oksida.

Oo waxaad hore u ogtahay oo aad fahantay in cuntooyinka ketogenic ay kor u qaadaan wax soo saarka mitochondria, hagaajinta shaqadooda, laakiin sidoo kale waxay ku dhiirigeliyaan unugyada maskaxda si ay u sameeyaan wax badan oo iyaga ka mid ah. Bal qiyaas sida ugu wanagsan ee unugga maskaxdu u maamuli karaan ROS iyada oo ay jiraan kuwo aad u tiro badan oo unugyo awood leh oo kor u qaadaya iyagoo tamar samaynaya. Tani waxay noqon kartaa habka uu cadaadiska oksaydhiyuhu u leeyahay suurtogalnimada in la yareeyo inta badan maskaxda laba-cirifoodka.

Ugu Dambeyn

Hadda oo aad baratay saamaynta xoogga leh ee cuntada ketogenic ee maskaxda hypometabolism, dheellitirka neurotransmitter, caabuqa, iyo cadaadiska oksaydhka waxaan kaa tagi doonaa xigashadan oo ka hadlaysa fikradda hadda jirta ee ku saabsan hababka cudurka ee aan ku aragno xanuunka laba-cirifoodka.

Qiyaasta cilmi-nafsiga ee cudurku waxay soo jeedinaysaa cilladaha taht ee unugyada biochemical cascades, walbahaarka oksaydhka iyo cillad la'aanta mitochondrial waxay wax u dhimaysaa geeddi-socodka ku xiran balaastigga neuronal, taasoo horseedaysa dhaawaca unugyada iyo khasaaraha ka soo baxa unugyada maskaxda ee lagu aqoonsaday dhimashada ka dib iyo neuroimaging.

Young, AH, & Juruena, MF (2020). Cilmi-nafsiga neerfaha ee cudurka laba-cirifoodka. Gudaha Cudurka laba-cirifoodka: Laga soo bilaabo cilmiga neerfaha ilaa daawaynta (pp. 1-20). Daadinta, Cham. https://link.springer.com/chapter/10.1007%2F7854_2020_179

Halkaa marka ay marayso, waxaan dareemayaa kalsooni inaad samayn karto isku xirkaas oo aad si fiican u fahamto sida cuntada ketogenic ay u noqon karto daaweyn xoog leh oo loogu talagalay xanuunka laba-cirifoodka ama midka qof aad jeceshahay.

Waxaan ka baqi lahaa inaan qoro bartan blog-ka ah dhowr sano ka hor, inkastoo ay jireen warbixino badan oo la yaab leh oo ka soo baxay dadka ka warbixinaya calaamadaha si weyn u wanaajiyay iyo shaqeynta. Aad ayaan ugu faraxsanahay inaan arko cilmi-baaris badan oo la sameynayo.

Sababta aan ugu kalsoonahay inaan ku qoro barta blog-ka sidan oo kale ah ayaa ah inay jiraan daraasado dib-u-eegis lagu sameeyay oo muujinaya cafiska calaamadaha laba-cirifoodka iyadoo la adeegsanayo cuntada ketogenic iyo RCT-yada socda ee eegaya cuntada ketogenic sida daaweynta xanuunka laba-cirifoodka. Xitaa waxaa jira shaqo ay cilmi-baarayaashu ku falanqeeyaan faallooyinka golayaasha halkaas oo dadka qaba xanuunka laba-cirifoodka ay ka wada hadlaan isticmaalka cuntada ketogenic si ay u dareemaan fiicnaan (eeg Ketosis iyo cudurka laba-cirifoodka: Daraasad la xakameeyey oo lagu sameeyay warbixinnada khadka).

Waxaa jira miis aad u fiican (Shaxda 1) ee maqaalka joornaalka Cunto ketogenic ah sida daaweynta dheef-shiid kiimikaad ee xanuunka laba-cirifoodka: Horumarrada kiliinikada kaas oo si hufan u qeexaya hababka ay cuntada ketogenic ku caawin karto daaweynta xanuunka laba-cirifoodka. Maadaama aad hadda wakhti qaadatay si aad u akhrido maqaalkan, waxaad si fiican u fahmi doontaa waxa miiskani ku xidhiidhinayo! Waxaan ku soo celiyay halkan:

Hababka BD	Calaamadaha BD	Saamaynta KD ee suurtagalka ah
Mitochondrial cillad	Hoos u dhaca heerka tamarta	Waxay keentaa biogenesis mitochondrial
Na/K ATPase luminta shaqada	Wax soo saarka ATP ee daciifka ah iyada oo loo marayo fosforyaalka Oxidative	Waxay bixisaa dariiq kale oo wax soo saar tamar ah oo loo maro ketosis
Hawlgabka PDC	Heerarka ATP-da ee aan sii jiri karin sababtoo ah soosaarka glycolysis-kaliya	Waxay bixisaa dariiqa wax soo saarka tamarta beddelka ah iyada oo loo marayo ketosis
Cadaadiska Oxidative	Kordhinta ROS taasoo horseedaysa dhaawaca neerfaha	Waxay hoos u dhigtaa heerarka ROS ee jirka ketone; Waxay kordhisaa heerarka HDL kolestaroolka ilaalinta neerfaha
Dhaqdhaqaaqa monoaminergic	Isbeddellada ku yimaadda hab-dhaqanka iyo shucuurta oo ay ugu wacan tahay isu-ururinta neurotransmitter-ka oo dheelli-tiran	Waxay ku xakameysaa dheef-shiid kiimikaad neurotransmitter iyada oo loo marayo jirka ketone iyo kuwa dhexdhexaadka ah
dopamine	Kordhinta firfircoonida soo-dhowaynta ee keenta calaamadaha waallida	Waxay hoos u dhigtaa dheef-shiid kiimikaadka dopamine
Serotonin	Heerarka hoos u dhaca ee keena calaamadaha niyad-jabka	Waxay hoos u dhigtaa dheef-shiid kiimikaadka serotonin
Norepinephrine	Heerarka hoos u dhaca ee keena calaamadaha niyad-jabka	Wax isbedel ah oo la taaban karo laguma arag daraasadihii hore
Gebacna	Heerarka hoos u dhaca ee la xiriira niyad-jabka iyo calaamadaha waallida	Waxay kordhisaa heerarka GABA
Glutamate	Kordhinta heerarka keenaya baahida tamarta aan sii waarin iyo dhaawaca neerfaha	Waxay hoos u dhigtaa heerarka glutamate
GSK-3 Enzyme cillad/Deficiency	Apoptosis iyo dhaawaca neerfaha	Waxay kordhisaa antioxidants si ay u bixiso neuroprotection

Haddii aad heshay boostada blog-ka mid waxtar leh ama mid xiiso leh, waxaa laga yaabaa inaad sidoo kale ku raaxaysato barashada sida cuntada ketogenic ay door uga qaadan karto wax ka beddelka muujinta hidda-wadaha.

Cunto ketogenic ma dhexdhexaadin kartaa saamaynta hidde-sideyaasha xanuunka laba-cirifoodka?

Haddii aad qabtid cudurro kale oo cudurro kale leh, waxaa laga yaabaa inaad ku caawiso inaad raadiso kayga blog (baaritaan ku yaal bogga hoose ee miisaska) oo arag haddii cuntada ketogenic ay saameyn faa'iido leh ku leedahay hababka cudurka sidoo kale. Qaar ka mid ah kuwa caanka ah ee laga yaabo inay khuseeyaan xanuunka laba-cirifoodka waxaa ka mid ah:

Keto ma daweyn karaa niyad-jabkayga daawo la'aan?

Cuntada Ketogenic waxay daaweysaa khamriga

Sidee bay cuntooyinka ketogenic u caawiyaan xanuunka welwelka?

Dhakhaatiirta caafimaadka maskaxda oo dadka ka caawiya inay u gudbaan cuntada ketogenic ee caafimaadka maskaxda iyo arrimaha neerfaha, waxaan kuu sheegi karaa in aan arko horumarinno marar badan kuwa si joogto ah u isticmaali kara cuntada ketogenic. Taasina waa inta badan bukaanadayda. Ma aha daawayn aan la sii wadi karin oo loogu talagalay xanuunka laba-cirifoodka ama mid kasta oo ka mid ah xanuunada kale ee aan ku daweeyo anigoo isticmaalaya cuntada ketogenic, teraabiyada cilminafsiga, iyo dhaqamada kale ee nafaqeynta ama shaqada dhimirka.

Waxaa laga yaabaa inaad ku raaxaysato akhrinta muunadayda yar ee Daraasadaha Kiis halkan. Qaar ka mid ah macaamiishayda, waxay ku saabsan tahay isku dayga wax aan ahayn dawooyinka lagu daweeyo xanuunka laba-cirifoodka. Inta badan, waxay ku saabsan tahay dhimista calaamadaha prodromal-ka ee ay sii wadaan inay la noolaadaan, qaar badanna waxay sii joogaan hal ama ka badan oo daawooyin ah. Badanaa qiyaas hoose.

Waxa kale oo laga yaabaa inaad ku raaxaysato qoraaladan kale ee ku saabsan xanuunka laba-cirifoodka iyo isticmaalka cuntada ketogenic halkan:

Cunto ketogenic ma dhexdhexaadin kartaa saamaynta hidde-sideyaasha xanuunka laba-cirifoodka?

Miyaan u baahanahay caawimo samaynta keto haddii aan qabo jirro dhimir?

Ilaha Caafimaadka Maskaxda ee Cuntada Ketogenic

Waxaa laga yaabaa inaad ka faa'iidaysato barashada barnaamijkayga khadka tooska ah ee aan isticmaalo si aan dadka u baro sida loogu gudbi karo cuntada ketogenic, falanqaynta nafaqeynta iyo tababarka caafimaadka shaqada si loo helo maskaxda ugu caafimaadka badan ee suurtogalka ah!

Barnaamijka Soo kabashada Ceerfaha Maskaxda

Ma jeceshahay waxa aad ka akhrinayso blog-ka? Ma doonaysaa inaad wax ka barato webinars-ka soo socda, koorsooyinka, iyo xataa waxay bixisaa taageero iyo ila shaqaynta ujeedooyinka caafimaadkaaga? Hoos iska diiwaan geli:

Tilmaamaha Nafaqada Maskaxda ee Bilaashka ah

---

tixraacyada

Benedetti, F., Aggio, V., Pratesi, ML, Greco, G., & Furlan, R. (2020). Neuroinflammation ee niyad-jabka laba-cirifoodka. Cudurka dhimirka ee maskaxda, 11. https://www.frontiersin.org/article/10.3389/fpsyt.2020.00071

Brady, RO, McCarthy, JM, Prescot, AP, Jensen, JE, Cooper, AJ, Cohen, BM, Renshaw, PF, & Ongür, D. (2013). Maskaxda gamma-aminobutyric acid (GABA) cilladaha aan caadiga ahayn ee xanuunka laba-cirifoodka. Laba-cirifoodka, 15(4), 434-439. https://doi.org/10.1111/bdi.12074

Campbell, I., & Campbell, H. (2019). pyruvate dehydrogenase khalkhalka kakan mala-awaalka xanuunka laba-cirifoodka. Muuqaal Caafimaad, 130, 109263. https://doi.org/10.1016/j.mehy.2019.109263

Campbell, IH, & Campbell, H. (2019). Ketosis iyo cudurka laba-cirifoodka: Daraasad la xakameeyey oo ku saabsan warbixinnada khadka. BJPsych Furan, 5(4). https://doi.org/10.1192/bjo.2019.49

Ching, CRK, Hibar, DP, Gurholt, TP, Nunes, A., Thomopoulos, SI, Abé, C., Agartz, I., Brouwer, RM, Cannon, DM, de Zwarte, SMC, Eyler, LT, Favre, P., Hajek, T., Haukvik, UK, Houenou, J., Landén, M., Lett, TA, McDonald, C., Nabulsi, L., … Kooxda, EBDW (2022). Waxa aan ka baranay xanuunka laba-cirifoodka ee neuroimaging baaxad weyn: Natiijooyinka iyo tilmaamaha mustaqbalka ee Kooxda Shaqada ee ENIGMA Bipolar Disorder Disorder. Maqnaanshaha Maskaxda Aadanaha, 43(1), 56-82. https://doi.org/10.1002/hbm.25098

Christensen, MG, Damsgaard, J., & Fink-Jensen, A. (2021). Isticmaalka cuntooyinka ketogenic ee daaweynta cudurrada habka dhexe ee neerfaha: Dib-u-eegis nidaamsan. Nordic Journal of Psychiatry, 75(1), 1-8. https://doi.org/10.1080/08039488.2020.1795924

Coello, K., Vinberg, M., Knop, FK, Pedersen, BK, McIntyre, RS, Kessing, LV, & Munkholm, K. (2019). Astaanta dheef-shiid kiimikaadka ee bukaannada qaba cudurka laba-cirifoodka ee dhawaan la ogaaday iyo qaraabadooda heerka koowaad ee aan waxba gaarin. Joornaalka Caalamiga ah ee Xanuunada Laba-cirifoodka, 7(1), 8. https://doi.org/10.1186/s40345-019-0142-3

Dahlin, M., Elfving, A., Ungerstedt, U., & Amark, P. (2005). Cunnada ketogenic waxay saamaysaa heerarka kicinta iyo asiidhyada amino-ka-hortagga ee CSF ee carruurta leh suuxdin refractory. Cilmi-baarista qallalka, 64(3), 115-125. https://doi.org/10.1016/j.eplepsyres.2005.03.008

Dahlin, M., Månsson, J.-E., & Åmark, P. (2012). Heerarka CSF ee dopamine iyo serotonin, laakiin ma aha norepinephrine, dheef-shiid kiimikaadka waxaa saameeya cuntada ketogenic ee carruurta qaba suuxdin. Cilmi-baarista qallalka, 99(1), 132-138. https://doi.org/10.1016/j.eplepsyres.2011.11.003

Dalai, Sethi (2021). Saamaynta Carbohydrate-ku-hooseeya, Dufan-sare, Cunto Ketogenic ah ee buurnaanta, cilladaha dheef-shiid kiimikaadka iyo calaamadaha dhimirka ee bukaannada qaba cudurka dhimirka ee Schizophrenia ama laba-cirifoodka: Tijaabo tijaabo ah oo furan (Diiwaangelinta Tijaabada Caafimaadka No. NCT03935854). clinicaltrials.gov. https://clinicaltrials.gov/ct2/show/NCT03935854

Delvecchio, G., Mandolini, GM, Arighi, A., Prunas, C., Mauri, CM, Pietroboni, AM, Marotta, G., Cinnante, CM, Triulzi, FM, Galimberti, D., Scarpini, E., Altamura, AC, & Brambilla, P. (2019). Isbeddellada qaab-dhismeedka iyo dheef-shiid kiimikaadka maskaxda ee u dhexeeya xanuunka laba-cirifoodka waayeelka ah iyo kala duwanaanta dabeecadda waallida hore ee hore: Daraasad MRI-PET oo la isku daray. Australian & New Zealand Journal of Maskaxda, 53(5), 413-423. https://doi.org/10.1177/0004867418815976

Delvecchio, G., Pigoni, A., Altamura, AC, & Brambilla, P. (2018b). Cutubka 10-Asalka garaadka iyo neerfaha ee hypomania: Aragtida hore ee ogaanshaha xanuunka laba-cirifoodka. Gudaha JC Soares, C. Walss-Bass, & P. ​​Brambilla (Eds.), Nuglaanta laba-cirifoodka (Bogga. 195-227). Saxaafadda tacliinta. https://doi.org/10.1016/B978-0-12-812347-8.00010-5

Df, T. (2019). Cilad-sheegashada Kala Duwan ee Garasho La'aanta Laba-cirifoodka: Warbixinta Kiis. Joornaalka Warbixinada Kiisaska Caafimaadka, 09(01). https://doi.org/10.4172/2165-7920.10001203

Cuntada iyo cuntooyinka caafimaadka ee cudurka Parkinson-ScienceDirect. (nd). La soo celiyay Febraayo 4, 2022, laga bilaabo https://www.sciencedirect.com/science/article/pii/S2213453019300230

Dilimulati, D., Zhang, F., Shao, S., Lv, T., Lu, Q., Cao, M., Jin, Y., Jia, F., & Zhang, X. (2022). Cunnada Ketogenic waxay wax ka beddeleysaa caabuqa neerfaha iyadoo la sii marinayo dheef-shiid kiimikaad ka timid Lactobacillus reuteri ka dib Dhaawac Fudud oo Maskaxda ah oo Soo noqnoqda [Preprint]. Dib u eegis. https://doi.org/10.21203/rs.3.rs-1155536/v1

Dorsal Anterior Cingulate Cortex— dulmar | Mawduucyada tooska ah ee Sayniska. (nd). La soo celiyay Janaayo 31, 2022, laga bilaabo https://www.sciencedirect.com/topics/medicine-and-dentistry/dorsal-anterior-cingulate-cortex

Dorsolateral Cortex - dulmar | Mawduucyada tooska ah ee Sayniska. (nd). La soo celiyay Janaayo 31, 2022, laga bilaabo https://www.sciencedirect.com/topics/neuroscience/dorsolateral-prefrontal-cortex

Duman, RS, Sanacora, G., & Krystal, JH (2019). Isku xirnaanta Isbeddelka ee niyad-jabka: GABA iyo Glutamate Neurotransmitter Deficits iyo Dib-u-noqoshada Daawaynta Cusub. Neuron, 102(1), 75-90. https://doi.org/10.1016/j.neuron.2019.03.013

Fatemi, SH, Folsom, TD, & Thuras, PD (2017). GABAA iyo GABAB dysregulation soo dhaweeye ee kiliyaha hore ee sare ee maaddooyinka qaba shisoofrani iyo xanuunka laba-cirifoodka. Synapse, 71(7), e21973. https://doi.org/10.1002/syn.21973

Fries, GR, Bauer, IE, Scaini, G., Valvassori, SS, Walss-Bass, C., Soares, JC, & Quevedo, J. (2020). Degdega gabowga nafleyda ee hippocampal ee cudurka laba-cirifoodka. Laba-cirifoodka, 22(5), 498-507. https://doi.org/10.1111/bdi.12876

Fries, GR, Bauer, IE, Scaini, G., Wu, M.-J., Kazimi, IF, Valvassori, SS, Zunta-Soares, G., Walss-Bass, C., Soares, JC, & Quevedo, J. (2017). Dardargelinta gabowga epigenetic iyo lambarka koobi ee mitochondrial DNA ee xanuunka laba-cirifoodka. Cilmi-nafsi maskaxeed, 7(12), 1-10. https://doi.org/10.1038/s41398-017-0048-8

Xuduudaha | DTI iyo Myelin Plasticity ee Cudurka laba-cirifoodka: Isku-dhafka Neuroimaging iyo Natiijooyinka Neuropathological | Dhimirka. (nd). La soo celiyay Janaayo 30, 2022, laga bilaabo https://www.frontiersin.org/articles/10.3389/fpsyt.2016.00021/full

Haarman, BCM (Benno), Riemersma-Van der Lek, RF, de Groot, JC, Ruhé, HG (Eric), Klein, HC, Zandstra, TE, Burger, H., Schoevers, RA, de Vries, EFJ, Drexhage , HA, Nolen, WA, & Doorduin, J. (2014). Neuroinflammation ee xanuunka laba-cirifoodka - A [11C] - (R) - PK11195 positron emission tomography. Maskaxda, Dabeecadda, iyo Xasaanadda, 40, 219-225. https://doi.org/10.1016/j.bbi.2014.03.016

Hallböök, T., Ji, S., Maudsley, S., & Martin, B. (2012). Saamaynta cuntada ketogenic ee dabeecadda iyo garashada. Cilmi-baarista qallalka, 100(3), 304-309. https://doi.org/10.1016/j.eplepsyres.2011.04.017

Hartman, AL, Gasior, M., Vining, EPG, & Rogawski, MA (2007). Cilmi-nafsiga Neuropharmacology ee Cuntada Ketogenic. Cudurka Neerfaha ee Carruurta, 36(5), 281. https://doi.org/10.1016/j.pediatrneurol.2007.02.008

Jensen, NJ, Wodschow, HZ, Nilsson, M., & Rungby, J. (2020). Saamaynta Jirka Ketone ee Metabolismka Maskaxda iyo Shaqada Cudurrada Neurodegenerative. Wargeyska Caalamiga ah ee Sayniska Molecular, 21(22). https://doi.org/10.3390/ijms21228767

Jiménez-Fernández, S., Gurpegui, M., Garrote-Rojas, D., Gutiérrez-Rojas, L., Carretero, MD, & Correll, CU (2021). Halbeegyada walbahaarka Oxidative iyo antioxidants ee bukaannada qaba xanuunka laba-cirifoodka: Natiijooyinka falanqaynta-meta ee isbarbardhigga bukaannada, oo ay ku jiraan xayndaabyada polarity iyo heerka euthymic, oo leh kontaroolo caafimaad qaba. Laba-cirifoodka, 23(2), 117-129. https://doi.org/10.1111/bdi.12980

Jones, GH, Vecera, CM, Pinjari, OF, & Machado-Vieira, R. (2021). Hababka calaamadaha bararka ee xanuunka laba-cirifoodka. Joornaalka Sayniska Biomedical, 28(1), 45. https://doi.org/10.1186/s12929-021-00742-6

Kato, T. (2005). Mitochondrial Disfunction iyo xanuunka laba-cirifoodka. Nihon Shinkei Seishin Yakurigaku Zasshi = Jariidada Jabbaan ee Cilmi-nafsiga, 25, 61-72. https://doi.org/10.1007/7854_2010_52

Kato, T. (2022). Mitochondrial dysfunction ee xanuunka laba-cirifoodka ( bogga 141-156). https://doi.org/10.1016/B978-0-12-821398-8.00014-X

Cunto ketogenic ee jirrada laba-cirifoodka. (2002). Laba-cirifoodka, 4(1), 75-75. https://doi.org/10.1034/j.1399-5618.2002.01212.x

Ketter, TA, Wang, Po. W., Becker, OV, Nowakowska, C., & Yang, Y.-S. (2003). Doorarka Kala Duwan ee Anticonvulsants ee Xanuunada Laba-cirifoodka. Annals of Mental Psychiatry, 15(2), 95-108. https://doi.org/10.3109/10401230309085675

Kovács, Z., D'Agostino, DP, dheeman, D., Kindy, MS, Rogers, C., & Ari, C. (2019). Daawaynta suurtagalka ah ee Kaabitaanka Ketone-ka Baxsan ee Ketosis-ka keentay ee Daaweynta Xanuunnada Dhimirka: Dib-u-eegista Suugaanta Hadda. Cudurka dhimirka ee maskaxda, 10. https://www.frontiersin.org/article/10.3389/fpsyt.2019.00363

Kuperberg, M., Greenebaum, S., & Nierenberg, A. (2020). Bartilmaameedka cillad-xumada Mitochondrial ee xanuunka laba-cirifoodka. Gudaha Mawduucyada hadda jira ee cilmiga neerfaha dabeecadda ( Juz. 48 ) . https://doi.org/10.1007/7854_2020_152

Lund, TM, Obel, LF, Risa, Ø., & Sonnewald, U. (2011). β-Hydroxybutyrate waa substrate-ka la door biday ee GABA iyo glutamate synthesis halka gulukoosta lama huraan yahay inta lagu guda jiro depolarization ee GABAergic neurons. Neurochemistry International, 59(2), 309-318. https://doi.org/10.1016/j.neuint.2011.06.002

Lund, TM, Risa, O., Sonnewald, U., Schousboe, A., & Waagepetersen, HS (2009). Helitaanka neurotransmitter glutamate waa la dhimaa marka beta-hydroxybutyrate ay badasho gulukooska ee neerfayaasha dhaqameed. Wargeyska Neurochemistry, 110(1), 80-91. https://doi.org/10.1111/j.1471-4159.2009.06115.x

Magalhães, PV, Kapczinski, F., Nierenberg, AA, Deckersbach, T., Weisinger, D., Dodd, S., & Berk, M. (2012). Culayska jirrada iyo xanuunka isku dhafan ee ku jira Barnaamijka Kobcinta Daaweynta Habaysan ee Cudurka Laba-cirifoodka. Ciladda maskaxda ee Scandinavica, 125(4), 303-308. https://doi.org/10.1111/j.1600-0447.2011.01794.x

Manalai, P., Hamilton, RG, Langenberg, P., Kosisky, SE, Lapidus, M., Sleemi, A., Scrandis, D., Cabassa, JA, Rogers, CA, Regenold, WT, Dickerson, F., Vittone, BJ, Guzman, A., Balis, T., Tonelli, LH, & Postolache, TT (2012). Immunoglobulin E positivity manka-gaar ah ayaa lala xiriiriyaa ka sii daraysa ee buufiska buufiska ee bukaanada cudurka laba-cirifoodka inta lagu jiro xilliga manka sare. Laba-cirifoodka, 14(1), 90-98. https://doi.org/10.1111/j.1399-5618.2012.00983.x

Marx, W., McGuinness, A., Rocks, T., Ruusunen, A., Cleminson, J., Walker, A., Gomes-da-Costa, S., Lane, M., Sanches, M., Paim Diaz, A., Tseng, P.-T., Lin, P.-Y., Berk, M., Clarke, G., O'Neil, A., Jacka, F., Stubbs, B., Carvalho, A., Quevedo, J., & Fernandes, B. (2021). Jidka kynurenine ee xanuunka weyn ee niyad-jabka, xanuunka laba-cirifoodka, iyo schizophrenia: Falanqaynta-meta ee daraasadaha 101. Cilmi-nafsi maskaxeed, 26. https://doi.org/10.1038/s41380-020-00951-9

Matsumoto, R., Ito, H., Takahashi, H., Ando, ​​T., Fujimura, Y., Nakayama, K., Okubo, Y., Obata, T., Fukui, K., & Suhara, T. (2010). Mugga walxaha cawlan ee la dhimay ee kortex cingulate dorsal ee bukaanada qaba xanuunka waswaaska ah: Daraasad morphometric ku salaysan voxel. Maskaxda iyo xanuunka neerfaha, 64(5), 541-547. https://doi.org/10.1111/j.1440-1819.2010.02125.x

McDonald, TJW, & Cervenka, MC (2018). Cuntooyinka Ketogenic ee Cudurrada Neerfaha ee Dadka Waaweyn. Neurotherapeutics, 15(4), 1018-1031. https://doi.org/10.1007/s13311-018-0666-8

Morris, A. A. M. (2005). Dheef-shiid kiimikaad ee maskaxda maskaxda. Joornaalka Cudurka dheef-shiid kiimikaadka ee la dhaxlo, 28(2), 109-121. https://doi.org/10.1007/s10545-005-5518-0

Motzkin, JC, Baskin-Sommers, A., Newman, JP, Kiehl, KA, & Koenigs, M. (2014). Xidhiidhka neerfaha ee xadgudubka muqaadaraadka: Xidhiidhka shaqada oo yaraada ee u dhexeeya meelaha abaalgudka gundhig u ah iyo xakamaynta garashada. Maqnaanshaha Maskaxda Aadanaha, 35(9), 4282. https://doi.org/10.1002/hbm.22474

Musat, EM, Marlinge, E., Leroy, M., Olié, E., Magnin, E., Lebert, F., Gabelle, A., Bennabi, D., Blanc, F., Paquet, C., & Cognat, E. (2021). Astaamaha Bukaan-socodka Laba-cirifoodka leh ee garashadoodu liidato ee Asal ahaan Neurodegenerative la tuhunsan yahay: Koox-kooxeedyo badan. Wargeyska Daawada Shakhsi ahaaneed, 11(11), 1183. https://doi.org/10.3390/jpm11111183

Newman, JC, & Verdin, E. (2017). β-Hydroxybutyrate: Dheef-shiid kiimikaad calaamadeynaya. Dib u eegis sanadeedka Nafaqada, 37, 51. https://doi.org/10.1146/annurev-nutr-071816-064916

O'Donnell, J., Zeppenfeld, D., McConnell, E., Pena, S., & Nedergaard, M. (2012). Norepinephrine: Neuromodulator-ka Kor u qaada Shaqada Noocyada Unugyada Badan si loo Wanaajiyo Waxqabadka CNS. Cilmi Baadhista dareemeyaasha, 37(11), 2496. https://doi.org/10.1007/s11064-012-0818-x

O'Neill, BJ (2020). Saamaynta cuntooyinka karbohaydrayt-yar-yar ee khatarta wadnaha, caabbinta insulin, iyo cilladda dheef-shiid kiimikaadka. Fikradda hadda jirta ee Endocrinology, Sonkorowga iyo Cayilka, 27(5), 301-307. https://doi.org/10.1097/MED.0000000000000569

Özerdem, A., & Ceylan, D. (2021). Cutubka 6 - Hababka neurooxidative iyo neuronitrosative ee xanuunka laba-cirifoodka: caddaynta iyo saamaynta. Gudaha J. Quevedo, AF Carvalho, & E. Vieta (Eds.), Neurobiology ee Cudurka laba-cirifoodka (Bogga. 71-83). Saxaafadda tacliinta. https://doi.org/10.1016/B978-0-12-819182-8.00006-5

Pålsson, E., Jakobsson, J., Södersten, K., Fujita, Y., Sellgren, C., Ekman, C.-J., Ågren, H., Hashimoto, K., & Landén, M. (2015) ). Calaamadaha calaamadaha glutamate ee dareeraha cerebrospinal iyo serum ee bukaannada qaba xanuunka laba-cirifoodka iyo kontaroolada caafimaadka qaba. Yurubta Neuropsychopharmacology: Jaamicadda Kuliyada Yurubta ee Neuropsychopharmacology, 25(1), 133-140. https://doi.org/10.1016/j.euroneuro.2014.11.001

(PDF) DTI iyo Myelin Plasticity ee Cudurka laba-cirifoodka: Isku-dubbaridka Neuroimaging iyo Natiijooyinka Neuropathological. (nd). La soo celiyay Janaayo 30, 2022, laga bilaabo https://www.researchgate.net/publication/296469216_DTI_and_Myelin_Plasticity_in_Bipolar_Disorder_Integrating_Neuroimaging_and_Neuropathological_Findings?enrichId=rgreq-ca790ac8e880bc26b601ddea4eddf1f4-XXX&enrichSource=Y292ZXJQYWdlOzI5NjQ2OTIxNjtBUzozNDIzODc0MTYxNTgyMTNAMTQ1ODY0MjkyOTU4OA%3D%3D&el=1_x_3&_esc=publicationCoverPdf

Pinto, JV, Saraf, G., Keramatian, K., Chakrabarty, T., & Yatham, LN (2021). Cutubka 30-aad-Biomarkers xanuunka laba-cirifoodka. Gudaha J. Quevedo, AF Carvalho, & E. Vieta (Eds.), Neurobiology ee Cudurka laba-cirifoodka (Bogga. 347-356). Saxaafadda tacliinta. https://doi.org/10.1016/B978-0-12-819182-8.00032-6

Rajkowska, G., Halaris, A., & Selemon, LD (2001). Dhimista cufnaanta neerfaha iyo glial waxay astaan ​​u tahay kiliyaha hore ee dorsolateral ee xanuunka laba-cirifoodka. Cilmi-nafsiga, 49(9), 741-752. https://doi.org/10.1016/s0006-3223(01)01080-0

Rantala, MJ, Luoto, S., Borráz-León, JI, & Krams, I. (2021). Cudurka laba-cirifoodka: Hab-nololeedka cilmi-nafsiga ee neuroimmunological. Faallooyinka Neuroscience & Biobehavior, 122, 28-37. https://doi.org/10.1016/j.neubiorev.2020.12.031

Rolstad, S., Jakobsson, J., Sellgren, C., Isgren, A., Ekman, CJ, Bjerke, M., Blennow, K., Zetterberg, H., Pålsson, E., & Landén, M. ( 2015). CSF neuroinflammatory biomarkers ee xanuunka laba-cirifoodka waxay la xiriiraan cillad xagga garashada. Yurubta Neuropsychopharmacology, 25(8), 1091-1098. https://doi.org/10.1016/j.euroneuro.2015.04.023

Roman Meller, M., Patel, S., Duarte, D., Kapczinski, F., & de Azevedo Cardoso, T. (2021). Laba-cirifoodka iyo waallida hore ee hore: Dib-u-eegis habaysan. Ciladda maskaxda ee Scandinavica, 144(5), 433-447. https://doi.org/10.1111/acps.13362

Romeo, B., Choucha, W., Fossati, P., & Rotge, J.-Y. (2018). Meta-falanqaynta heerarka dhexe ee γ-aminobutyric acid ee dhexda iyo durugsan ee bukaanada qaba niyad-jabka unipolar iyo laba-cirifoodka. Joornaalka Cilmi-nafsiga iyo Cilmi-nafsiga, 43(1), 58-66. https://doi.org/10.1503/jpn.160228

Rowland, T., Perry, BI, Upthegrove, R., Barnes, N., Chatterjee, J., Gallacher, D., & Marwaha, S. (2018). Neurotrophins, cytokines, dhexdhexaadiyeyaasha cadaadiska oksaydhka iyo xaaladda niyadda ee xanuunka laba-cirifoodka: Dib-u-eegis nidaamsan iyo falanqayn-mete. Joornaalka Ingiriiska ee cilmu-nafsiga, 213(3), 514-525. https://doi.org/10.1192/bjp.2018.144

Saraga, M., Misson, N., & Cattani, E. (2020). Cunto ketogenic ah ee xanuunka laba-cirifoodka. Laba-cirifoodka, 22. https://doi.org/10.1111/bdi.13013

Sayana, P., Colpo, GD, Simões, LR, Giridharan, VV, Teixeira, AL, Quevedo, J., & Barichello, T. (2017). Dib-u-eegis nidaamsan oo caddaynaya doorka biomarkers bararka ee bukaannada laba-cirifoodka. Joornaalka Cilmi-baarista Cilmi-nafsiga, 92, 160-182. https://doi.org/10.1016/j.jpsychires.2017.03.018

Selemon, LD, & Rajkowska, G. (2003). Cilmi-baadhista unugyada ee kortex-ka hore ee dorsolateral waxay ka soocaysaa schizophrenia iyo xanuunka laba-cirifoodka. Daawooyinka Molecular ee Hadda, 3(5), 427-436. https://doi.org/10.2174/1566524033479663

Shi, J., Badner, JA, Hattori, E., Potash, JB, Willour, VL, McMahon, FJ, Gershon, ES, & Liu, C. (2008). Gudbinta neerfayaasha iyo xanuunka laba-cirifoodka: Daraasad Urur qoys oo nidaamsan. Joornaalka Mareykanka ee Hiddaha Caafimaadka. Qaybta B, Genetics Neuropsychiatric: Daabacaadda Rasmiga ah ee Bulshada Caalamiga ah ee Hiddaha Dhimirka, 147B(7), 1270. https://doi.org/10.1002/ajmg.b.30769

Shiah, I.-S., & Yatham, LN (2000). Serotonin ee mania iyo habka ficil-celinta niyadda: dib u eegista daraasadaha kiliinikada. Laba-cirifoodka, 2(2), 77-92. https://doi.org/10.1034/j.1399-5618.2000.020201.x

Stertz, L., Magalhães, PVS, & Kapczinski, F. (2013). Cudurka laba-cirifoodka ma yahay xaalad barar ah? Ku habboonaanta firfircoonida microglial. Fikradda hadda ku jirta maskaxda, 26(1), 19-26. https://doi.org/10.1097/YCO.0b013e32835aa4b4

Sugawara, H., Bundo, M., Kasahara, T., Nakachi, Y., Ueda, J., Kubota-Sakashita, M., Iwamoto, K., & Kato, T. (2022a). Falanqaynta methylation DNA-ga-nooca-unugga u gaarka ah ee kiliyeyaasha hore ee jiirarka beddelka ah ee Polg1 oo leh ururinta neuronal ee DNA-da mitochondrial ee tirtiray. Maskaxda Molecular, 15(1), 9. https://doi.org/10.1186/s13041-021-00894-4

Sugawara, H., Bundo, M., Kasahara, T., Nakachi, Y., Ueda, J., Kubota-Sakashita, M., Iwamoto, K., & Kato, T. (2022b). Falanqaynta methylation DNA-ga-nooca-unugga u gaarka ah ee kiliyeyaasha hore ee jiirarka beddelka ah ee Polg1 oo leh ururinta neuronal ee DNA-da mitochondrial ee tirtiray. Maskaxda Molecular, 15(1), 9. https://doi.org/10.1186/s13041-021-00894-4

Sun, Z., Bo, Q., Mao, Z., Li, F., He, F., Pao, C., Li, W., He, Y., Ma, X., & Wang, C. (2021). La dhimay Plasma Dopamine-β-Hydroxylase Activity waxay ku xidhan tahay darnaanta xanuunka laba-cirifoodka: Daraasad tijaabo ah. Cudurka dhimirka ee maskaxda, 12. https://www.frontiersin.org/article/10.3389/fpsyt.2021.566091

Szot, P., Weinshenker, D., Rho, JM, Storey, TW, & Schwartzkroin, PA (2001). Norepinephrine ayaa looga baahan yahay saamaynta anticonvulsant ee cuntada ketogenic. Cilmi-baadhista Horumarinta Maskaxda, 129(2), 211-214. https://doi.org/10.1016/S0165-3806(01)00213-9

Ułamek-Kozioł, M., Czuczwar, SJ, Januszewski, S., & Pluta, R. (2019). Cunto Ketogenic ah iyo suuxdin. Nafaqooyinka, 11(10). https://doi.org/10.3390/nu11102510

Hellwig, S., Domschke, K., & Meyer, PT (2019). Cusbooneysii PET ee xanuunka neurodegenerative iyo neuroinflammatory ee ka muuqda heerka dabeecadda: sawir-qaadista ogaanshaha kala duwanaanshaha. Fikradda hadda ee Neurology, 32(4), 548-556. doi: 10.1097/WCO.0000000000000706

Wan Nasru, WN, Ab Razak, A., Yacquub, NM, & Wan Azman, WN (2021). Beddelka alanine balaasmaha, glutamate, iyo heerka glycine: Dhacdo manic awood leh oo xanuunka laba-cirifoodka ah. Wargeyska Malaysiya ee Pathology, 43(1), 25-32.

Westfall, S., Lomis, N., Kahouli, I., Dia, S., Singh, S., & Prakash, S. (2017). Microbiome, probiotics iyo cudurada neurodegenerative: Go'aaminta dhidibka maskaxda ee mindhicirka. Sayniska Nolosha Cellular iyo Molecular: CMLS, 74. https://doi.org/10.1007/s00018-017-2550-9

Young, AH, & Juruena, MF (2021). Cilmi-nafsiga neerfaha ee cudurka laba-cirifoodka. Gudaha AH Young & MF Juruena (Eds.), Cudurka laba-cirifoodka: Laga soo bilaabo cilmiga neerfaha ilaa daawaynta ( bogga 1-20). Springer International Publishing. https://doi.org/10.1007/7854_2020_179

Yu, B., Ozveren, R., & Sethi Dalai, S. (2021a). Isticmaalka karbohaydrayt hooseeya, cuntada ketogenic ee xanuunka laba-cirifoodka: dib u eegis nidaamsan [Preprint]. Dib u eegis. https://doi.org/10.21203/rs.3.rs-334453/v1

Yu, B., Ozveren, R., & Sethi Dalai S. (2021b). Cunto ketogenic ah sida daaweynta dheef-shiid kiimikaad ee xanuunka laba-cirifoodka: Horumarrada kiliinikada [Preprint]. Dib u eegis. https://doi.org/10.21203/rs.3.rs-334453/v2

Yudkoff, M., Daiqin, Y., Nissim, I., Lazarow, A., & Nissim, I. (2004). Cunto ketogenic ah, dheef-shiid kiimikaad glutamate maskaxda iyo xakamaynta suuxdinta. Prostaglandins, Leukotrienes, iyo Asiidhyada Dufanka Aasaasiga ah, 70(3), 277-285. https://doi.org/10.1016/j.plefa.2003.07.005

Zhu, H., Bi, D., Zhang, Y., Kong, C., Du, J., Wu, X., Wei, Q., & Qin, H. (2022). Cunto Ketogenic ah oo loogu talagalay cudurrada bini'aadamka: hababka asaasiga ah iyo suurtagalnimada hirgelinta bukaan-socodka. Beddelka Calaamadaha iyo Daaweynta La Beegsado, 7(1), 1-21. https://doi.org/10.1038/s41392-021-00831-w

β-Hydroxybutyrate, oo ah jirka ketone, wuxuu yareeyaa saameynta cytotoxic ee cisplatin iyada oo loo marayo firfircoonida HDAC5 ee unugyada epithelial kelyaha ee bini'aadamka-PubMed. (nd). La soo celiyay Janaayo 29, 2022, laga bilaabo https://pubmed.ncbi.nlm.nih.gov/30851335/