Waqtiga akhriska ee la qiyaasay: 19 daqiiqo

Hordhac

Haddii aad akhrinayso qoraalkan baloogga ah, waxay noqon kartaa sababtoo ah waxaad hore uga shakiday ama aad leedahay ogaanshaha garaadka khafiifka ah (MCI). Xaaladaha qaarkood ee daciifnimada garaadka fudud (MCI) waxay joogsan doonaan horusocod mana u dhaqaaqi doonaan shaqada daciifka ah ee heer si ay u buuxiyaan shuruudaha asaasaqa.

Waa maxay garaadka fudud (MCI)? Halkan ka bilow:

Laakin badi kiisaska garaadka khafiifka ah (MCI) waxay u koraan waallida. Xitaa haddii horumarka neerfayaashaada uu ku istaago cillad garaadka fudud (MCI), calaamadahaasi waxay saameeyaan tayada noloshaada iyo shaqadaada. Nasiib darro, ma jiraan daaweyn gaar ah oo loogu talagalay noocaan hoos u dhaca garashada guud ee laga helo daawada caadiga ah, dhab ahaantii, waxaa jira, daaweyno leh cilmi-baaris heer sare ah oo la helay si loo hagaajiyo shaqada.

Markaa haddii aad rabto in maskaxdaadu dib uga soo noqoto hoos u dhaca garashada hore ee qaab ceeryaamo maskaxda ah oo soo noqnoqda ama daba-dheeraada iyo/ama cillad garaadka khafiifka ah (MCI), ama aad rabto inaad joojiso horumarka neurodegenerative ee Alzheimer ama nooc kale oo waallida, tani waa barta blogka adiga. Waxaa laga yaabaa inaad akhrinayso qoraalkan baloogga sababtoo ah maaha inaad la ildaran tahay calaamadaha hoos u dhaca garashada laakiin sababtoo ah waxaad baadhaysaa sida loo caawiyo qof aad jeceshahay. Oo haddii ay taasi tahay kiiska, tani weli waa barta blog-ka adiga.

3 Sababood oo Dhibtaada Xusuustaada ah aysan Caadi ahaan karin iyo waxa aad ka qaban karto

Waxaa jiri kara arrimo badan oo gacan ka geysta hoos u dhaca garashada. Laakin taasi yaysan kaa badin. Waxaa jirta meesha ugu horeysa ee laga bilaabo taas oo hagaajin doonta calaamadaha waxayna dejin doontaa marxalad kasta oo kale oo baaritaan iyo hagaajin u baahan in la sameeyo. Waxaa jira waxyaabo badan oo maskaxda ka khaldama oo leh calaamadaha garashada. Maqaalkan, waxaynu kaga hadli doonaa laba aragtiyood oo ku saabsan waxa khaldan oo aan u arko inay yihiin caddayn aad u adag. Kadib waxaan ka hadli doonaa tillaabada ugu horeysa ee ugu fiican si aan u bilaabo wax ka qabashada iyo ka dib waxa aan u arko inay waxtar u leeyihiin shaqadayda lataliyaha caafimaadka dhimirka ee shatiga leh anigoo isticmaalaya mabaadi'da nafaqeynta iyo shaqada maskaxda ee shaqadayda macaamiisha. Qaar badan oo iyaga ka mid ah ayaa la ildaran calaamadaha garashada, oo leh ama aan la aqoonsanayn inay yihiin cillado niyadda, da'o kala duwan.

Qiyaasta Shabakadda ee Cudurka Alzheimers

Mala-awaalkani waxa uu leeyahay caddayn aad u wanaagsan oo lagu taageero oo waxa uu isticmaalaa xogta MRI shaqaynaysa. Waxa ay dareemeen ayaa ah in ay dhibaato ka jirto sida qaababka kala duwan ee maskaxdu ay ula hadlaan midba midka kale iyo in ay dhacdo goor hore habka cudurka. Dhab ahaantii, dadka qaba cudurka Alzheimers (tusaale ahaan, sidayaal APOE-ε4) waxay bilaabi karaan inay arkaan isku xirnaanta cilladaysan ka hor calaamad kasta. Waxay u egtahay in ay ka bilaabato shabakadda qaab-dhismeedka dambe (DMN), oo marka ay bilowdo inay u safarto shabakadda dareenka dhabarka (DAN), cilmi-baarayaashu waxay bilaabaan inay arkaan calaamado ka soo baxaya garaadka khafiifka ah (MCI). Qaybtan maskaxda ka mid ah waxay samaysaa waxa cinwaankeedu tilmaamayo. Waxay kuu ogolaaneysaa inaad fiiro gaar ah u yeelato. Haddii aanad u fiirsi la'aan, si fiican uma qaadan kartid macluumaadka, xusuusta episodic waxay noqotaa mid daciif ah.

e·i·sodic memo·ry – magac (Oxford Languages ​​via Google) waa nooc ka mid ah xusuusta muddada-dheer oo ku lug leh dib u xasuusashada waaya-aragnimadii hore oo ay weheliso xaaladdooda marka la eego wakhtiga, goobta, dareenka la xidhiidha, iwm.
"Natiijooyinkaasi waxay soo jeedinayaan in ka qaybgalayaashu ay isticmaalayeen xusuusta episodic si ay u xusuustaan ​​erayada la soo bandhigay dhammaan xaaladaha"

xasuus miyir leh oo waayo-aragnimo hore.
"Hippocampus wuxuu si ba'an ugu lug leeyahay samaynta xasuuso xasaasi ah" 

Sida cilmi-baarayaashu u daawadaan hoos u dhaca horumarka isku-xirnaanta shaqada, waxay u eegi karaan oo xitaa saadaalin karaan waxqabadka hoos u dhaca ee hawlaha fiiro gaar ah oo ay ku jiraan feejignaanta, jihaynta waxa u baahan fiiro gaar ah, iyo feejignaan. Waxaa sidoo kale hoos u dhacay isku xirnaanta shaqeynta ee shabakada salience, oo ay ku jiraan qaababka muhiimka ah ee maskaxda ee xuubka hore iyo ventral anterior insular cortices, kuwaas oo sidoo kale ay ku jiraan qanjidhada muhiimka ah ee isgaarsiinta amygdala, ventral striatum, brainstem, thalamus, iyo hypothalamus. Dad kala duwan ayaa la kulmi doona arrimo isku xirnaanta qaybaha kala duwan ee maskaxda, sidaas darteed waxaa laga yaabaa inaad aragto dhibaatooyinka awoodda qofka si uu u qiimeeyo shaqadooda ama khalkhalka aragga marka cudurka uu sii socdo.

Tamar Maskaxdu kuma filna

Haddii aad leedahay calaamadaha cilladda neerfayaasha (ceeryaamo maskaxda, MCI, waallida), waxaad maskaxdaada ku haysaa dhibaatooyin dheef-shiid kiimikaad tamarta gulukooska. Taasi micneheedu waa maxay? Waxay la macno tahay inay jiraan qaybo maskaxdaada ka mid ah oo qaadanaya gulukoos yar oo soo saara tamar yar. Waxayna u badan tahay inay ka dhacayso xudunta ku meel gaadhka ah ee dhexdhexaadka ah ee ay ku jiraan hippocampus, kortexka entorhinal, iyo kiliyaha dambe ee cingulate aan hadda ka hadalnay, taas oo qayb ka ah DMN-da danbe. Tani waa dhibaato sababtoo ah kuwani waa meelaha ay cilmi-baarayaashu ogyihiin inay ku lug leeyihiin marka xusuusta episodic ay daciifto. Laakiin hoos u dhacan ku yimi shidaalka qaybahan maskaxda ayaa ah wax aad uga badan shaqada xusuusta oo kaliya. Waxaa muhiim ah in la fahmo in maskaxdu ay qaadato xaddi badan oo tamar ah si ay u ilaaliso neerfayaasha, iyo marka ay jirto tamar yaraan, unugyada maskaxdaadu ma qaban karaan hawlo aasaasi ah si ay u hubiyaan caafimaadka iyo shaqada unugyada:

• xuubka ilaalinta
• abuurista iyo shaqada baytariyada unugyada (mitochondria)
• kaydinta nafaqooyinka loo baahan yahay si loo abuuro neurotransmitters iyo enzymes
• isagoo leh garaacyo xoog leh oo awood leh si ay u calaamadiyaan neurons dhexdooda

Waxaan sii wadi karaa oo ku saabsan dhammaan siyaabaha kaliya oo aan tamar ku filan maskaxda ku haynin waxay abuurtaa qulqulka neurodegenerative taas oo u dhiganta tareenka baxsadka ah ee garaadka garashada.

Hadda, hadalkan waxaa ku filan oo ku saabsan waxa khaldan. Aan bilowno dooda sidii loo hagaajin lahaa.

Geli Ketones

Ketones ayaa siiya shidaal kale oo loogu talagalay aagagga maskaxda ee tamartu ay hayso. Xusuusnow doodeena ku saabsan meelaha qaarkood ee maskaxda oo aan awoodin inay gulukoosta u isticmaasho shidaalka sidoo kale? Ketonesku waxay dhaafaan hababkaas khaldan waxayna hagaajiyaan dheef-shiid kiimikaadka tamarta. Ketones waa unugyo calaamadeynaya, waxayna leeyihiin shaqooyin kale oo badan oo cajiib ah oo aan ahayn shidaal kale.  

Waxqabadyada Ketogenic hadda waa istaraatijiyad rajo leh oo neurotherapeutic si loo soo celiyo hawlaha garashada ee MCI iyo AD

Roy, M., Edde, M., Fortier, M., Croteau, E., Castellano, CA, St-Pierre, V., … & Descoteaux, M. (2022). Faragelinta ketogenic waxay hagaajinaysaa shabakada dareenka dhabarka ee shaqaynaysa iyo isku xidhka qaabdhismeed ee daciifnimada garashada fudud. Neurobiology ee Gabowga. https://doi.org/10.1016/j.neurobiolaging.2022.04.005

Faa'iidada ugu cad ee ketones waxay bixisaa waa shidaalka meelaha gaajada ee maskaxda. Laakiin waxay sameeyaan wax badan oo dheeraad ah. Ketones dhisme ahaan waxay muhiim u yihiin ilaalinta unugyada maskaxda iyo bogsashada. Tusaale ahaan, waxay dhisayaan galka galka myelin-ka ee ka ilaaliya neerfaha dabka koronto ee awoodaha ficil waxayna u baahan yihiin dayactir joogto ah. Doorkooda sida jidhka calaamadaha, waxay u jeestaan ​​​​dariiqyada ka hortagga caabuqa, inkastoo aan ku doodi lahaa in haddii lagu tiirsado ketone supplements oo keliya iyada oo aan la beddelin cunto barar ah, faa'iidooyinkani waxay noqon doonaan kuwo aan la ogaan karin qofka ka shaqeeya si uu u bogsado maskaxdiisa. Ketones waxay yareeyaan cadaadiska oksaydhka waxayna wanaajiyaan isku xidhka dhismayaasha maskaxda, xitaa gudaha meelaha cad ee qoto dheer ee maskaxda. Waxay hagaajiyaan wax soo saarka maskaxda-Derived Neurotrophic Factor (BDNF), taas oo gacan ka geysata hagaajinta isku xirnaanta iyo hagaajinta neerfayaasha, walaxdani waxay door dhow ka ciyaartaa xusuusta iyo hippocampus.

Ketones waxay sidoo kale wanaajisaa daacadnimada xannibaadda dhiigga-maskaxda, taas oo leh shaqo muhiim ah oo ka ilaalinta maskaxda sunta ama walxaha kale ee keeni kara hababka bararka ee kordhin kara dhaawaca maskaxda. Waxay hagaajiyaan wax soo saarka glutathione, kaas oo ah nidaamka antioxidant-ka ee jidhku leeyahay ee loogu talagalay inuu ka caawiyo la dagaallanka diiqada oksaydhka (haa, gaar ahaan maskaxda).

Ketones waxay bixiyaan faragelin heerar badan ah si aan loo badbaadin oo kaliya shaqada garashada laakiin si loo bogsiiyo maskaxda oo gaabis ama suurtogal ah xitaa inay joojiyaan, hababka neurodegenerative.

Daaweynta Ketogenic

Markaad samaynayso cilmi-baaris ku saabsan sida loo hagaajiyo shaqada garashada, waxaad la kulmi doontaa daraasado ku saabsan ketones iyo siyaabaha kala duwan ee ketones loo bixin karo. Waxa jira ketones ka baxsan oo qofku cabbi karo ama ku dari karo cuntada qaab saliidda MCT, tusaale ahaan. Ama waxaa jira ketones laga sameeyay qofka oo jejebiya dufanka cuntada ama dufanka jidhkooda oo noqda jidhka ketone. Waxaana jira, dabcan, isku darka labada. Daraasadaha intooda badani waxay eegayaan saliidda MCT. Saliidda MCT waa shidaal aad u fiican maskaxda, waxaana aad ugu talinayaa. Laakin waxa ay keeni kartaa dhib badan oo dheefshiidka, marka waa in si tartiib tartiib ah loogu shaqeeyaa qiyaaso. Si kastaba ha ahaatee, sababtoo ah waxay leedahay cillado dheefshiidka oo kala duwan (shuban) dad badan, way adkaan kartaa ama mararka qaarkood xitaa aan macquul ahayn in la shaqeeyo ilaa qiyaas ka yareeya calaamadaha.

Marka laga eego aragtida dhabta ah, haddii aad qof ka codsato inuu qaato saliidda MCT, waxay kuu sheegi doonaan xitaa qaado (15mL) waxay sababi kartaa arrimo. Hal daraasad, waxaan eegay ka qaybgalayaasha oo ay ahayd inay ku bilaabaan 50mL (qiyaastii 3 TBSP) oo ay ka shaqeeyaan ilaa 250mL (qiyaastii 17 TBSP). Ka qaybgalayaashu waxay ahayd in la shaqeeyo ilaa xad aad u weyn oo ka badan 6 bilood, iyo nooca caddaynta hore ee daraasadda (waqtiga aan qoray boggan blog) ma cayimin inta jeer ee kaqeybgalayaashu ay u baahan yihiin inay iskood u qaataan. (Fiiri Roy, et al., 2022 ee tixraacyada).

Sababta kaliya qaadashada saliid badan ee MCT maaha jawaabta

Xaaladdaada caabbinta insulin waxay sidoo kale muhiim u tahay horumarka cudurka neurodegenerative. Aad bay u fiican tahay inaad ku kordhiso shidaalka maskaxdaada saliidda MCT, taas oo kaa caawin doonta bixinta ketones si ay u sameeyaan dhammaan waxyaalaha maskaxdaada bogsiinaya. Laakin diirada saara kaliya kordhinta ketones kama aysan hadlin xaqiiqda ah in maskaxda ku soo qulqula gulukooska aysan ahayn maskax faraxsan. Haddii aad yeelatay caabbinta insulin, waxaad u baahan doontaa inaad si weyn u beddesho cuntadaada si aad u hagaajiso ama aad u beddesho xaaladda cudurkan.

Gaar ahaan, halka shakhsiyaadka leh gulukooska soonka ee sii kordhaya aysan weli muujin hoos u dhaca garashada, waxay ku yeesheen atrophy goboleed ee hippocampus iyo kiliyaha parietal hoose, iyo korodhka amyloid ururinta kortex-ka hore.

Honea, RA, John, CS, Green, ZD, Kueck, PJ, Taylor, MK, Lepping, RJ, … & Morris, JK (2022). Xidhiidhka gulukooska soonka iyo calaamadaha sawir-qaadista ee cudurka Alzheimers. Alzheimer & Dementia: Cilmi-baarista Tarjumaadda & Daaweynta Caafimaadka, 8(1), e12239. https://doi.org/10.1002/trc2.12239

Sidoo kale, markaad da'daadu sii korodho, suurtogalnimada inaad yeeshay iska caabbinta insulinta ayaa kordheysa, iyo hagaajinta dareenkaaga insulinta waxay kaa caawin kartaa inaad iska ilaaliso cudurrada gabowga. Dadka leh iska caabbinta insulin-ta sare waxay halis sare ugu jiraan habab badan oo cudurro ah, ha ahaato si toos ah hab sababeed ama, ugu yaraan, hab urureed iyo tuhun. Waa kuwee qaar ka mid ah cudurrada laga helo xididdada caabbinta insulin ee aan la daweyn? Mise, ugu yaraan, urur aad u sarreeya? Waxaa ka mid ah kuwan soo socda:

• Wadnaha - Dhiig karka, Atherosclerosis, Wadnaxanuun xanuunka, profiles hyperlipidemia
• Neerfaha - Cudurka Alzheimers, Cudurka Parkinson, Waallida xididdada dhiigga, Madax xanuunka Migraine, Neuropathy
• Kansarka - Naasaha, Prostate, iyo Colorectal
• Musculoskeletal - Sarcopenia, lafo-xanuun, lafo-xanuun
• Dheefshiidka - Rooda, Dib-u-celinta Esophagitis (GERD), Dhibaatooyin saxaro dhaaf ah (Gastroparesis)
• Cudurka Beerka - Hyperlipidemia (waxay muujinaysaa dhibaatada beerka, ma aha nidaamka wadnaha), Cudurka beerka dufanka leh ee aan khamriga ahayn,
• Xameetida iyo Cudurada kelyaha - Dhagaxyada xameetida, Dhagxaanta kelyaha, kelyaha oo fashilma

Nidaamyadan cudurku waxay xadayaan tamartaada iyo tayada noloshaada si la mid ah si la mid ah calaamadaha garashada ee aan la daweyn iyo cudurka Alzheimers ama waallida kale. Laakiin xaqiiqdaas ka sokow, hababkan cudurrada daba-dheeraada waxay sidoo kale si dadban u saameeyaan maskaxdaada.

Kaliya in maskaxda la siiyo ilo kale oo shidaal ah maaha faragelin ku filan oo loogu talagalay daciifnimada garashada fudud ama hore ee cudurka Alzheimers. Ma aha haddii aan daneyno jirka oo dhan iyo tayada noloshaada mustaqbalka. Tusaale ahaan, haddii aad naftaada siiso saliid badan oo MCT ah, oo aad dareento fiicnaan maskaxdaada, laakiin ha beddelin cuntadaada si aad u beddesho caabbinta insulin (taas oo cuntooyinka ketogenic ay sameeyaan), markaa marka uu atherosclerosis sii socdo, waxaad bilaabi doontaa inaad yeelato cudurrada wadnaha iyo xididdada dhiigga. .

Marka uu cudurka wadnahaagu sii socdo, waxaad bilaabi doontaa inaad la kulanto dhibaatooyin ogsajiinta iyo nafaqooyinka lagu shubo maskaxdaada iyo jidhkaaga intiisa kale. Taasina waa mid ka mid ah habab badan oo ku daciifa cudurrada wadnaha iyo xididdada kuwaas oo saameyn ku yeelan kara caafimaadka maskaxda. Nidaamka wadnaha iyo xididdada dhiigga oo xumaada ayaa runtii saameyn doona maskaxdaada. Waxba igama gelin inta saliidda MCT aad qaadato.

Ugu Dambeyn

Waxaan arkaa natiijooyin caafimaad oo aad uga wanaagsan markaan hirgelinno cunto ketogenic ah oo loogu talagalay daawaynta cilladda garashada, haddii ay tahay ceeryaamo maskaxeed oo aad u daran oo dad badani la kulmaan, oo si rasmi ah loo ogaado cillad garaadka fudud (MCI), ama xitaa waallida hore. Saliidda MCT iyo dheellitirka ketone ee dibadda ka baxsan ayaa loo isticmaalaa in lagu dhiso saldhigga ketogenic ee shidaalka maskaxda kaas oo ku dhaca xaddidaadda karbohaydraytyada daweynta. Saliidda MCT waa kobcin. Ma aha faragelinta waxa badbaadiya maskaxdaada. Saliidda MCT lafteeda ayaa ah isku dayga band-caawinta ee hababka neerfayaasha. Iyadoo aan la dhimin karbohaydraytyada daaweeya hyperglycemia iyo iska caabbinta insulin, si ku filan kama hadlaysid hababka neurodegenerative ee sii wadi doona inay ku dhacaan asalka. Hadday kuwani si toos ah uga dhacaan maskaxda (kuwaas oo aan dammaanad ka qaadayo inay yihiin) ama habka labaad ee cudurrada daba dheeraada, sida kuwii aan hore u akhrinay.

Kuuma sheego cilladaha saliidda MCT ee daaweynta hababka neerfayaasha si ay kaaga dhigaan rajo-beel. Waan ogahay suurtagalnimada in aad beddesho cuntadaada si ay u hoos u dhigto, u joojiso ama xitaa u beddelo habka cudurkaaga ay adag tahay, waxaana laga yaabaa inaadan hubin sida ay taasi xitaa u ekaan karto. Waxa laga yaabaa inaad u aragto qoraalladan baloogga ah inay waxtar leeyihiin.

Xeerarka cuntada Keto ee caafimaadka maskaxda

Keto miisaaniyad loogu talagalay caafimaadka dhimirka

Waxaan tan u qorayaa sababtoo ah haddii adiga ama qof aad jeceshahay ay la ildaran yihiin calaamadaha garashada, ma rabo inaad qiyaasto saliidda MCT, aadan arag horumar, ka dibna iska daa rumaysashada in ketones ay ku caawin karto. Saliidda MCT oo keliya maaha mid la mid ah heerka dhexgalka ee cuntada ketogenic ee si fiican loo habeeyey, mana aha faragelin la mid ah oo aad la kulmi doonto haddii aad labada isku geyso. Waxaan haystaa macaamiil badan oo aan dareemin wax farqi ah marka la kordhiyo saliidda MCT laakiin dareema in maskaxdoodu bogsanayso oo ay hagaajiyaan shaqada iyagoo isticmaalaya cunto ketogenic ah.

Markaa haddii saliidda MCT aanay yarayn calaamadahaaga, fadlan ha niyad jabin.

Bixinta ketones, ha ahaato iyada oo loo marayo cunto ketogenic si fiican loo qaabeeyey ama korodhka la-qaadista MCT, waa tallaabada ugu horreysa ee badbaadinta shaqada garashada. Tallaabooyinka labaad waxay noqon karaan falanqaynta nutrigenomic si loo hubiyo qaadashada nafaqeeyayaalka yar yar ee ku filan iyo baaritaan dheeraad ah si meesha looga saaro arrimaha kale ee habka cudurka, oo inta badan lagu sameeyo baaritaanka daawada shaqeynta. Laakiin marka hore, waa in aan samatabbixin tamarta maskaxda.

Ketones ayaa sidaas sameeya.

Laakiin wax kasta oo aad go'aansato, waqti ha lumin. Waqtigu waa nuxurka daawaynta xanuunada neurodegenerative.

Haddii aad la ildaran tahay calaamadaha garashada ee qaabka ceeryaamo maskaxda, dhib u fiirsashada ama xusuusta waxyaabaha, ama u fiirsashada, iyo dhibaatooyinka niyadda waxaad u baahan doontaa inaad wax badan ka barato barnaamijkayga internetka.

Barnaamijka Soo kabashada Ceerfaha Maskaxda

Haddii aad jeclaan lahayd inaad iska diiwaan geliso liiska boostada si aad wax uga barato barnaamijyada soo socda, koorsooyinka, iyo fursadaha waxbarasho, waxaad ku samayn kartaa halkan:

Sababtoo ah waxaad xaq u leedahay inaad ogaato dhammaan siyaabaha aad ku dareemi karto fiicnaan.

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tixraacyada

Achanta, LB, & Rae, CD (2017). β-Hydroxybutyrate ee Maskaxda: Hal Molecule, Farsamooyin badan. Cilmi Baadhista dareemeyaasha, 42(1), 35-49. https://doi.org/10.1007/s11064-016-2099-2

An, Y., Varma, VR, Varma, S., Casanova, R., Dammer, E., Pletnikova, O., Chia, CW, Egan, JM, Ferrucci, L., Troncoso, J., Levey, AI , Lah, J., Seyfried, NT, Legido-Quigley, C., O'Brien, R., & Thambisetty, M. (2018). Caddeynta gulukoosta maskaxda ee cillad la'aanta ee cudurka Alzheimers. Cudurka Alzheimers & Dementia, 14(3), 318-329. https://doi.org/10.1016/j.jalz.2017.09.011

Avgerinos, KI, Egan, JM, Mattson, MP, & Kapogiannis, D. (2020). Silsiladda dhexe ee Triglycerides waxay keentaa ketosis khafiif ah waxayna wanaajin kartaa garashada cudurka Alzheimers. Dib-u-eegis habaysan iyo falanqayn-maro-baadhiseed oo lagu sameeyo daraasaadka aadanaha. Dib u eegisyada Cilmi-baarista Gabowga, 58, 101001. https://doi.org/10.1016/j.arr.2019.101001

Balthazar, MLF, de Campos, BM, Franco, AR, Damasceno, BP, & Cendes, F. (2014). Shabakadda kortikal oo dhan iyo qaabka caadiga ah waxay ka dhigan tahay isku xirnaanta shaqaynaysa sida biomarkers suurtagalka ah ee cudurka Alzheimers ee fudud. Cilmi-baarista Maskaxda: Neuroimaging, 221(1), 37-42. https://doi.org/10.1016/j.pscychresns.2013.10.010

Banjara, M., & Janigro, D. (nd). Saamaynta Cunnooyinka Ketogenic ee Xubinta Dhiiga-Maskaxda. Gudaha Cuntada Ketogenic iyo Daaweynta dheef-shiid kiimikaadka. Jaamacadda Oxford Press. La soo celiyay Janaayo 8, 2022, laga bilaabo https://oxfordmedicine.com/view/10.1093/med/9780190497996.001.0001/med-9780190497996-chapter-30

Bernard, C., Dilharreguy, B., Helmer, C., Chanraud, S., Amieva, H., Dartigues, J.-F., Allard, M., & Catheline, G. (2015). Tilmaamaha PCC ee nasashada 10-sano ee xusuusta hoos u dhaca. Neurobiology ee Gabowga, 36(10), 2812-2820. https://doi.org/10.1016/j.neurobiolaging.2015.07.002

Bickman, B. (2020). Waa maxay sababta aan u jirranno: Cudurka faafa ee qarsoon ee asalka u ah cudurrada daba-dheeraada - iyo sida loola dagaallamo. BenBella Books, Inc.

Carneiro, L., & Pellerin, L. (2021). Saamaynta Nafaqada ee Homeostasis dheef-shiid kiimikaadka iyo Caafimaadka Maskaxda. Xannibaadyada ku jira neuroscience, 15. https://doi.org/10.3389/fnins.2021.767405

Croteau, E., Castellano, CA, Fortier, M., Bocti, C., Fulop, T., Paquet, N., & Cunnane, SC (2018). Isbarbardhigga qaybaha kala duwan ee gulukoosta maskaxda iyo dheef-shiid kiimikaadka ketone ee dadka waaweyn ee garashada caafimaadka qaba, cillad garaadka fudud iyo cudurka Alzheimers ee hore. Gerontology tijaabada ah, 107, 18-26. https://doi.org/10.1016/j.exger.2017.07.004

Cunnane, SC, Trushina, E., Morland, C., Prigione, A., Casadesus, G., Andrews, ZB, Beal, MF, Bergersen, LH, Brinton, RD, de la Monte, S., Eckert, A ., Harvey, J., Jeggo, R., Jhamandas, JH, Kann, O., la Cour, CM, Martin, WF, Mithieux, G., Moreira, PI, … Millan, MJ (2020). Badbaadinta tamarta maskaxda: Fikradda daawaynta soo ifbaxday ee xanuunada neurodegenerative ee gabowga. Natiijooyinka Falanqaynta Dabeecadda Daawada, 19(9), 609-633. https://doi.org/10.1038/s41573-020-0072-x

Dheef-shiid kiimikaadka hippocampal oo hoos u dhacay heerka-amyloid-fudud ee garaadka daciifnimada fudud—Hanseeuw—2016—Alzheimer's & Dementia—Wiley Online Library. (nd). La soo celiyay Abriil 16, 2022, laga bilaabo https://alz-journals.onlinelibrary.wiley.com/doi/full/10.1016/j.jalz.2016.06.2357

Habka Shabakadda Default— dulmar | Mowduucyada tooska ah ee Sayniska. (nd). La soo celiyay Abriil 16, 2022, laga bilaabo https://www.sciencedirect.com/topics/neuroscience/default-mode-network

Dewsbury, LS, Lim, CK, & Steiner, GZ (2021). Waxtarka Dawaynta Ketogenic ee Maareynta Kiliinikada ee Dadka qaba Cudurka Neerfaha: Dib-u-eegis Nidaamsan. Horumarka laga gaaray Nafaqada, 12(4), 1571-1593. https://doi.org/10.1093/advances/nmaa180

Shabakadda Feejignaanta Dorsal— dulmar | Mowduucyada tooska ah ee Sayniska. (nd). La soo celiyay Abriil 16, 2022, laga bilaabo https://www.sciencedirect.com/topics/medicine-and-dentistry/dorsal-attention-network

Waji-iyo Gulukoos-Gaarka Xun ee Tamarta Matter Matter ee Cudurka Alzheimers-IOS Press. (nd). La soo celiyay Abriil 16, 2022, laga bilaabo https://content.iospress.com/articles/journal-of-alzheimers-disease/jad200213

Garoonka, R., Garoonka, T., Pourkazemi, F., & Rooney, K. (2021). Cuntooyinka Ketogenic iyo habdhiska dareenka: Dib-u-eegis xaddidan oo ku saabsan natiijooyinka neerfaha ee ketosis nafaqeynta ee daraasaadka xayawaanka. Dib u eegisyada Cilmi-baarista Nafaqada, 1-14. https://doi.org/10.1017/S0954422421000214

Forsythe, CE, Phinney, SD, Fernandez, ML, Quann, EE, Wood, RJ, Bibus, DM, Kraemer, WJ, Feinman, RD, & Volek, JS (2008). Isbarbardhigga Cuntooyinka Dufanka Yar iyo Kaarbohaydrayt-yar ee Wareegaya Isku-dhafka Aashitada Dufan iyo Calaamadaha caabuqa. Lipids, 43(1), 65-77. https://doi.org/10.1007/s11745-007-3132-7

Gano, LB, Patel, M., & Rho, JM (2014). Cuntooyinka ketogenic, mitochondria, iyo cudurrada neerfaha. Wargeyska Cilmi-baarista Lipid, 55(11), 2211-2228. https://doi.org/10.1194/jlr.R048975

Gough, SM, Casella, A., Ortega, KJ, & Hackam, AS (2021). Ilaalinta neerfaha ee Ketogenic Diet: Caddaynta iyo Murannada. Xannibaadyada Nafaqada, 8, 782657. https://doi.org/10.3389/fnut.2021.782657

Grammatikopoulou, MG, Goulis, DG, Gkiouras, K., Theodoridis, X., Gkouskou, KK, Evangeliou, A., Dardiotis, E., & Bogdanos, DP (2020). Ku socota Keto ama maya? Dib-u-eegis Habaysan oo Tijaabooyin La Xakamaysan Yahay oo Qiimaynta Saamaynta Ketogenic Therapy ee Cudurka Alzheimers. Horumarka laga gaaray Nafaqada, 11(6), 1583-1602. https://doi.org/10.1093/advances/nmaa073

Hodgetts, CJ, Shine, JP, Williams, H., Boostada, M., Sims, R., Williams, J., Lawrence, AD, & Graham, KS (2019). Kordhinta waxqabadka shabakada qaab-dhismeedkooda dambe iyo isku xidhka qaabdhismeed ee da'yarta APOE-ε4 sideyaasha: Baadhitaanka sawir-qaadista badan. Neurobiology ee Gabowga, 73, 82-91. https://doi.org/10.1016/j.neurobiolaging.2018.08.026

Honea, RA, John, CS, Green, ZD, Kueck, PJ, Taylor, MK, Lepping, RJ, Townley, R., Vidoni, ED, Burns, JM, & Morris, JK (2022). Xidhiidhka gulukooska soonka iyo calaamadaha sawir-qaadista ee cudurka Alzheimers. Alzheimer & Dementia: Cilmi-baarista Tarjumaadda & Daaweynta Caafimaadka, 8(1), e12239. https://doi.org/10.1002/trc2.12239

Huang, J., Xeebta, P., Bozoki, A., & Zhu, DC (2021). Cudurka Alzheimers wuxuu si tartiib tartiib ah u yareeyaa isku xirnaanta Shabakadda Waxqabadka Muuqaalka. Joornaalka Warbixinta Cudurka Alzheimers, 5(1), 549-562. https://doi.org/10.3233/ADR-210017

Jensen, NJ, Wodschow, HZ, Nilsson, M., & Rungby, J. (2020). Saamaynta Jirka Ketone ee Metabolismka Maskaxda iyo Shaqada Cudurrada Neurodegenerative. Wargeyska Caalamiga ah ee Sayniska Molecular, 21(22). https://doi.org/10.3390/ijms21228767

Jones, DT, Graff-Radford, J., Lowe, VJ, Wiste, HJ, Gunter, JL, Senjem, ML, Botha, H., Kantarci, K., Boeve, BF, Knopman, DS, Petersen, RC, & Jack, CR (2017). Tau, amyloid, iyo shabkada cascading oo guuldarraystay dhammaan noocyada cudurka Alzheimers. kiliyaha, 97, 143-159. https://doi.org/10.1016/j.cortex.2017.09.018

Jones, DT, Knopman, DS, Gunter, JL, Graff-Radford, J., Vemuri, P., Boeve, BF, Petersen, RC, Weiner, MW, Jack, CR, Jr, & magaca cudurka Alzheimers Neuroimaging hindise. (2016). Shabakadda cascading failure ee guud ahaan cudurka Alzheimers spectrum. Maskaxda, 139(2), 547-562. https://doi.org/10.1093/brain/awv338

Juby, AG, Blackburn, TE, & Mager, DR (2022). Isticmaalka saliidda silsiladda dhexdhexaadka ah ee triglyceride (MCT) ee maadooyinka qaba cudurka Alzheimers: A randomized, double-inard, placebo-controlled, crossover study, oo leh calaamad furan oo kordhin. Alzheimer & Dementia: Cilmi-baarista Tarjumaadda & Daaweynta Caafimaadka, 8(1), e12259. https://doi.org/10.1002/trc2.12259

Kovacs, Z., D'Agostino, DP, & Ari, C. (2022). Kahortagga neerfaha iyo faa'iidooyinka dabeecadda ketones dibadda ah. Gudaha Cuntada Ketogenic iyo Daaweynta dheef-shiid kiimikaadka: Doorarka la ballaariyay ee caafimaadka iyo cudurrada ( daqada 2aad, bogga 426-465). Jaamacadda Oxford Press. 10.1093/med/9780197501207.001.0001

Masino, SA, & Rho, JM (2012). Farsamooyinka Waxqabadka Cuntada Ketogenic. Gudaha JL Noebels, M. Avoli, MA Rogawski, RW Olsen, & AV Delgado-Escueta (Eds.), Hababka aasaasiga ah ee Jasper ee Cudurrada ( daqada 4aad.). Xarunta Qaranka ee Macluumaadka Bayolojiyada (US). http://www.ncbi.nlm.nih.gov/books/NBK98219/

Morris, A. A. M. (2005). Dheef-shiid kiimikaad ee maskaxda maskaxda. Joornaalka Cudurka dheef-shiid kiimikaadka ee la dhaxlo, 28(2), 109-121. https://doi.org/10.1007/s10545-005-5518-0

Newman, JC, & Verdin, E. (2017). β-Hydroxybutyrate: Dheef-shiid kiimikaad calaamadeynaya. Dib u eegis sanadeedka Nafaqada, 37, 51. https://doi.org/10.1146/annurev-nutr-071816-064916

Ranganath, C., & Ritchey, M. (2012). Laba hab-kortikal oo loogu talagalay hab-dhaqanka lagu hagayo xusuusta. Dabeecadaha Dabeecadda ee Neuroscience, 13(10), 713-726. https://doi.org/10.1038/nrn3338

Roy, M., Edde, M., Forier, M., Croteau, E., Castellano, C.-A., St-Pierre, V., Vandenberghe, C., Rheault, F., Dadar, M., Duchesne, S., Bocti, C., Fulop, T., Cunnane, SC, & Descoteaux, M. (2022). Faragelinta ketogenic waxay hagaajinaysaa shabakada dareenka dhabarka ee shaqaynaysa iyo isku xidhka qaabdhismeed ee daciifnimada garashada fudud. Neurobiology ee Gabowga. https://doi.org/10.1016/j.neurobiolaging.2022.04.005

Roy, M., Fortier, M., Rheault, F., Edde, M., Croteau, E., Castellano, C.-A., Langlois, F., St-Pierre, V., Cuenoud, B., Bocti, C., Fulop, T., Descoteaux, M., & Cunnane, SC (2021). Kaabista ketogenic waxay wanaajisaa sahayda tamarta walxaha cad iyo xawaaraha habaynta ee daciifnimada garashada fudud. Alzheimer & Dementia: Cilmi-baarista Tarjumaadda & Daaweynta Caafimaadka, 7(1), e12217. https://doi.org/10.1002/trc2.12217

Saito, ER, Miller, JB, Harari, O., Cruchaga, C., Mihindukulasuriya, KA, Kauwe, JSK, & Bikman, BT (2021). Cudurka Alzheimers wuxuu beddelaa oligodendrocytic glycolytic iyo ketolytic muujinta hidda-socodka. Cudurka Alzheimers & Dementia, 17(9), 1474-1486. https://doi.org/10.1002/alz.12310

Schultz, AP, Buckley, RF, Hampton, OL, Scott, MR, Properzi, MJ, Peña-Gómez, C., Pruzin, JJ, Yang, H.-S., Johnson, KA, Sperling, RA, & Chhatwal, JP (2020). Burburinta muddada dheer ee dhidibka shabakadda salience/salience ee shakhsiyaadka calaamadaha leh ee leh culeyska amyloid ee sarreeya. Neuroimage: kiliinic, 26, 102052. https://doi.org/10.1016/j.nicl.2019.102052

Seeley, WW (2019). Shabakadda Salience: Nidaamka Dareemaha ee Garashada iyo Ka-jawaabista Dalabka Guriga. Joornaalada Nuuryaaniga, 39(50), 9878-9882. https://doi.org/10.1523/JNEUROSCI.1138-17.2019

Shimazu, T., Hirschey, MD, Newman, J., He, W., Shirakawa, K., Le Moan, N., Grueter, CA, Lim, H., Saunders, LR, Stevens, RD, Newgard, CB , Farese, RV, de Cabo, R., Ulrich, S., Akassoglou, K., & Verdin, E. (2013). Xakamaynta Cadaadiska Oxidative by β-Hydroxybutyrate, Histone Deacetylase Inhibitor Endogenous. Science, 339(6116), 211-214. https://doi.org/10.1126/science.1227166

Shippy, DC, Wilhelm, C., Viharkumar, PA, Raife, TJ, & Ulland, TK (2020). β-Hydroxybutyrate waxay joojisaa firfircoonida bararka si ay u yaraato pathology-ga cudurka Alzheimers. Wargeyska Neuroinflammation, 17(1), 280. https://doi.org/10.1186/s12974-020-01948-5

Staffaroni, AM, Brown, JA, Casaletto, KB, Elahi, FM, Deng, J., Neuhaus, J., Cobigo, Y., Mumford, PS, Walters, S., Saloner, R., Karydas, A., Coppola, G., Rosen, HJ, Miller, BL, Seeley, WW, & Kramer, JH (2018). Jidka Dheeraadka ah ee Isku xidhka Shabakadda Qaabka Default ee Dadka Waaweyn ee Caafimaadka qaba way kala duwan yihiin iyadoo ay tahay shaqada da'da oo waxay la xidhiidhaa isbeddellada xusuusta Episodic iyo Xawaaraha socodsiinta. Jariidadda Neuroscience, 38(11), 2809-2817. https://doi.org/10.1523/JNEUROSCI.3067-17.2018

Shabakadda Salience: Nidaamka Neural ee Garashada iyo Ka-jawaabista Dalabyada Guriga | Wargeyska Neuroscience. (nd). La soo celiyay Abriil 16, 2022, laga bilaabo https://www.jneurosci.org/content/39/50/9878

Thomas, JB, Brier, MR, Bateman, RJ, Snyder, AZ, Benzinger, TL, Xiong, C., Raichle, M., Holtzman, DM, Sperling, RA, Mayeux, R., Ghetti, B., Ringman, JM, Salloway, S., McDade, E., Rossor, MN, Ourselin, S., Schofield, PR, Masters, CL, Martins, RN, … Ances, BM (2014). Isku xirnaanta shaqaynaysa ee Autosomal Dominant iyo Cudurka Alzheimer oo goor dambe bilaabmay. Jaamac Nuuroloji, 71(9), 1111-1122. https://doi.org/10.1001/jamaneurol.2014.1654

Valera-Bermejo, JM, De Marco, M., & Venneri, A. (2022). Is-dhex-galka Is-beddelka ee Shabakadaha Hawl-galka Maskaxda ee Weyn ayaa wax ka beddela Anosognosia-ka-badan ee Anosognosia ee Cudurka Alzheimers ee Hore. Xuduudaha hore ee Aging Neuroscience, 13, 781465. https://doi.org/10.3389/fnagi.2021.781465

van Niekerk, G., Davis, T., Patterton, H.-G., & Engelbrecht, A.-M. (2019). Sidee bararku-u-abuuray hyperglycemia u sababa cilladda Mitochondrial ee Unugyada Difaaca? BioEssays: Wararka iyo Dib u eegisyada Molecular, Cellular iyo Biology Koriinka, 41(5), e1800260. https://doi.org/10.1002/bies.201800260

Vemuri, P., Jones, DT, & Jack, CR (2012). Nasashada MRI ee shaqaynaysa gobolka ee Cudurka Alzheimers. Cilmi-baarista & Daaweynta Alzheimers, 4(1), 2. https://doi.org/10.1186/alzrt100

Cunnada karbohaydrayt-ku-yar ee aadka u yar waxay xoojisaa difaaca jirka ee T-unugga iyada oo loo marayo dib-u-habaynta difaaca jirka. (2021). EMBO molecular Medicine, 13(8), e14323. https://doi.org/10.15252/emmm.202114323

Vizuete, AF, de Souza, DF, Guerra, MC, Batasini, C., Dutra, MF, Bernardi, C., Costa, AP, & Gonçalves, C.-A. (2013). Isbeddelka maskaxda ee BDNF iyo S100B oo ay keentay cuntooyinka ketogenic ee jiirka Wistar. Sayniska Nolosha, 92(17), 923-928. https://doi.org/10.1016/j.lfs.2013.03.004

Yamanashi, T., Iwata, M., Kamiya, N., Tsunetomi, K., Kajitani, N., Wada, N., Iitsuka, T., Yamauchi, T., Miura, A., Pu, S., Shirayama, Y., Watanabe, K., Duman, RS, & Kaneko, K. (2017). Beta-hydroxybutyrate, oo ah endogenic NLRP3 inhibitor inhibitor, waxay hoos u dhigtaa habdhaqanka walaaca iyo jawaabaha bararka. Warbixinno cilmi ah, 7(1), 7677. https://doi.org/10.1038/s41598-017-08055-1