Sidee cunnada ketogenic u caawin kartaa in ay bogsato maskaxda soo daatay oo ay ka dhigto xannibaadda dhiigga-maskaxda mid xooggan oo adkaysi badan?
Waqtiga akhriska ee la qiyaasay: 17 daqiiqo
Runtii taasi waa su'aal wanaagsan. Markaa waan ka jawaabi doonaa. Maqaalkan blog-ka ah, waxaanu kaga hadli doonaa waxa uu yahay xannibaadda dhiigga-maskaxda, calaamadaha aan filan karno inay dhacaan haddii ay xumaato oo dillaacdo, iyo xitaa shaybaarka shaybaarka oo loo isticmaali karo in la isku dayo in lagu qiimeeyo haddii ay dillaacday.
Caqabadahaaga dhiigga-maskaxda (BBB) waa mid aad muhiim u ah.
Marka hore, wax yar oo ah anatomy iyo shaqada. Kaliya waa kugu filan si aad u fahanto waxa ku lug leh.
BBB-du waxay ka soocaysaa dhiigga dheecaanka cerebrospinal ee ka baxsan unugyada waxayna maskaxda ka ilaalisaa cudurrada dhiigga ka dhasha iyo sunta iyadoo u oggolaanaysa faafinta ogsijiinta, kaarboon-dioxide, iyo molecules lipophilic yar yar / ethanol. Dayactirka BBB waxay lagama maarmaan u tahay xakamaynta adag ee ka kooban kiimikada dareeraha maskaxda (ISF) ee lagama maarmaanka u ah shaqada synaptika iyo sidoo kale bixinta nooc ka hortag ah cudurada dhiiga raaca.
Kakaroubas, N., Brennan, S., Keon, M., & Saksena, NK (2019). Pathomechanisms ee carqaladaynta xannibaadda dhiigga-maskaxda ee ALS. Joornaalka Neuroscience, 2019. https://doi.org/10.1155/2019/2537698
BBB waa ururinta xididdada dhiigga iyo astrocytes kuwaas oo si wadajir ah walxaha maskaxda uga ilaaliya wareegga nidaamka. Waxay leedahay gaadiid-qaadayaal kala duwan oo u oggolaanaya waxyaabaha qaar inay dhex maraan.
Laakin sida mindhicirka dilaaca marka BBB uu hoos u dhaco caafimaadka ma ilaalin karo daacadnimadeeda oo waxa gala maskaxda oo aan ahayn. Kuwaas waxaa ka mid noqon kara:
- Kiimikada iyo Sunta Deegaanka
- Bakteeriyada (fayrasyada iyo bakteeriyada)
- Barootiinnada cuntada (tusaale, gluten)
- Dhexdhexaadiyeyaasha kala duwan ee caabuqa ee dhiigga (tusaale, lipopolysaccharide)
- Unugyada lidka ku ah wareegga wareegga
- Isku dheelitir la'aanta hoormoonka (hypothyroidism run ah)
Marka ay waxyaalahani ka gudbaan xannibaad dhiig-maskaxeed oo dareere ah waxay dhaqaajiyaan habka difaaca maskaxda si ay isugu dayaan inay maskaxda ka ilaaliyaan. Gaar ahaan, unugyada microglial ayaa hawl gala. Haddii aad qabtid BBB-da daadsan, waxay la macno tahay in waxyaaluhu ay halkaas ka kacayaan mar kasta oo aan lahayn. Tani waxay ka dhigan tahay firfircoonida microglial si joogto ah u dhacaya. Taasi ma fiicna. Taasi waxay dejisaa marxaladda caabuqa neuroinflammation ee dabadheeraad ah. Oo haddii maskaxdaadu aanay si dhakhso ah isu hagaajin karin si ay ula socoto dhaawaca ka imanaya caabuqa neuroinflammation ee daba-dheeraada, waxay kuu dejinaysaa habka neerfayaasha.
Maskaxdu waxay u baahan tahay nafaqeeyayaal yar yar si ay u hagaajiso dhaawaca, u sameeyaan neurotransmitters iyo enzymes muhiim ah, iyo si ay u dhaliyaan tamar. Ma ogtahay sida maskaxdaadu u hesho inta badan fiitamiinada ay uga baahan tahay hababkaas? BBB kaaga. Haa, taasi waa sax! Inta badan fiitamiinada biyaha ku milma (tusaale, fiitamiinada B) iyo dheef-shiid kiimikaad kale oo muhiim ah ayaa loo qaadaa maskaxda iyadoo la isticmaalayo gaadiidleyda gaarka ah ee BBB.
Qaar ka mid ah gaadiidleydaas waxaa loo isticmaalaa in lagu gudo gulukoos maskaxda. Maaddaama aan ka wada hadalnay qodobbada hore, tani qasab kuma aha in lagu sameeyo gulukoosta aad cuntid. Jirkaagu wuxuu ka badan yahay inuu ku faraxsanaado inuu sameeyo gulukoosta shaashadda oo aad ugu baahan tahay qaybo ka mid ah maskaxdaada inaad shaqeyso. Laakiin haddii BBB-gaaga uu waxyeello u geysto oo loo adeegsado gaadiidleyda ujeeddadiisu waa waxyeello ama aan shaqeynin (BBB waxay noqon karaan insulin u adkaysi doontid) markaa uma baahnid inaad ku isticmaasho gulukoosta tamar. Sidan, sidan oo kale, xubinta ka sii dartay ayaa dhici karta oo si xun u sii dayn kartaa waxay sii kordhin kartaa dhibaatooyinka tamarta maskaxda.
Haddii BBB-gaagu dhaawacmo, taasi waxay dhibaato u keeni kartaa dhammaan gaadiidleydaas, kuwaas oo shaqadoodu tahay inay maskaxdaada nafaqo iyo shidaal geliyaan.
Tani waxay ka dhigan tahay in maskaxdaadu ay aad uga dhaqso badan tahay sidii loogu talagalay. Wax dhib ah ma leh haddii aad tahay 15 ama 27 ama 34 ama 40 ama 50s ama 60s. Nidaamyada neurodegenerative waxay dhacaan da 'kasta. BBB daadanaya maaha dhibka qofka da'da ah. Waa "qof kasta oo da 'kasta oo dhibaato ah." Waxayna u baahantahay in laga fiirsado oo wax laga qabto.
Ha i fahmin. Waan ku faraxsanahay inaan arko GUT-da daadsan oo helaya waqti-hawleed iyo walaac badan. Waan ka nastay inay ugu dambeyntii ku jirto raadaarka dadka si dhab ah. Bogsiinta mindhicirka qulqulaya waa muhiim sababtoo ah waxaad u baahan tahay inaad ka ilaaliso habka difaaca jirka si aad uga ilaaliso habka difaaca maskaxdu inuu noqdo mid firfircoon. Waxaad u baahan tahay marinnada dheefshiidka caafimaadka leh si aad awood ugu yeelatid inaad jebiso oo aad nuugo nafaqooyinkaaga mindhicirkaaga waxaadna u baahan tahay microbiome caafimaad leh malaha bilyan sababood.
Waxaad wax badan ka baran kartaa microbiomes caafimaad qaba halkan.
Waxaase jirta caqabad kale oo u baahan in kor loo qaado oo ay fahmaan dadweynaha iyo dadka la daalaa dhacaya maskaxda oo aan u shaqayn sidii ay rabaan. Waana sababta qoraalkan loo qorayo. Maskaxda daadsan waa wax.
Marka BBB la jebiyo waxa ugu weyn ee dhaca waa in aad qaado neuroinflammation. Marka uu jiro habka neerfaha, dadku waxay bilaabaan inay ka cawdaan calaamadaha ceeryaamo maskaxda.
Marka aad qabtid ceeryaamo maskaxda, waxay la macno tahay in wax faragelinayaan shaqada caadiga ah ee synapse.
Synapses waxay ka kooban yihiin qayb aad u khaas ah oo muhiim u ah unugyada neerfaha. Waxay yihiin goobaha aasaasiga ah ee isgaadhsiinta u dhexeeya unugyada neerfaha, sidaas darteed, waxay ku lug leeyihiin dhammaan dhinacyada physiology neuronal. Shaqada saxda ah ee synaptik waa shardi u ah shaqada caadiga ah ee maskaxda, xitaa khalkhal yar ayaa keeni kara xanuunada neerfaha.
Xylaki, M., Atzler, B., & Outeiro, TF (2019). Epigenetics of Synapse ee Neurodegeneration. Warbixinnada neerfaha iyo cilmiga neerfaha ee hadda, 19(10), 1-10. https://doi.org/10.1007/s11910-019-0995-y
Neuroinflammation wuxuu farageliyaa xawaaraha socodka dareemayaasha waxaana laga yaabaa inaad dareento in fekerka iyo hawlaha dhaqdhaqaaqa ay noqdaan kuwo waxtarkoodu yar yahay ama si fudud u yimaadaan. Neuroinflammation sidoo kale "lammaane" mitochondria. Mitochondria waa mashiinnada gacantaada. Waxay ku siinayaan tamarta unuggaagu u baahan yahay inuu ku shaqeeyo. Laga soo bilaabo toogashada synapses-yadaas ilaa lagu ilaalinayo caafimaadka unugga tamarta si loo sameeyo ilaalinta guriga aasaasiga ah. Sidee ayay dareemayaan mitochondria oo aan is-qabin? Waxay dareemeysaa daal maskaxeed. Maskaxdaadu si degdeg ah ayay u daashaa. Waxaa laga yaabaa inaadan ku wadi karin taraafikada culus, u adkeysan kartid isdhexgalka bulsheed ee dheer ama ma akhrin kartid intii aad isticmaali jirtay. Awooddaada inaad ku qabato hawlaha iyo fiiro gaar ah ayaa hoos u dhacay.
Neuroinflammation wuxuu noqon karaa wax oo yaraada. Toddobaadyada qaar waxaa jira niyadda iyo khalkhal garaadka, iyo toddobaadyo kale waxaad la kulmi doontaa wax ka yar calaamadahaas. Tani waxay si fudud ula macno tahay in maskaxdu ay leedahay xoogaa guulo ah, mararka qaarkood, maaraynta habka bararka iyo hagaajinta neurodegeneration sida ay u dhacayso.
Laakiin sida aad qiyaasi karto, sababaha asaasiga ah ee abuuraya BBB-da qulqulaya waa in aan la iska indho-tirin, mararka qaarkoodna ceeryaamo maskaxdu waxay noqon kartaa mid daba-dheer, maadaama habka difaaca jirku uu noqdo mid joogto ah oo xad-dhaaf ah oo heerka dhaawaca uu gaaro hababka antioxidant-ka ee jirka. , abuurista cadaadiska oksaydhka iyo dejinta hababka muhiimka ah ee neurodegenerative.
Caddaynta sii kordheysa waxay muujineysaa in cadaadiska oksaydhative (OS) uu door muhiim ah ka ciyaaro kicinta isbeddelada BBB.
Kadry, H., Noorani, B., Bickel, U., Abbruscato, TJ, & Cucullo, L. (2021). Qiimaynta isbarbardhigga ee in vitro BBB daacadnimada isgoysyada cidhiidhiga ah ka dib soo-gaadhista qiiqa sigaarka iyo uumiga sigaarka elektaroonigga ah: Qiimaynta tirada ee saamaynta ilaalinta metformin iyadoo la isticmaalayo calaamado-yar oo miisaan-molecular ah. Dheecaannada iyo caqabadaha CNS, 18(1), 1-15. https://doi.org/10.1186/s12987-021-00261-4
Waxaan sii sheegaa hababkan "nidaamka" neurodegenerative sababtoo ah mararka qaarkood neurodegenerative ayaa dhacaya, marka ay u sii korodho wax daba-dheeraada (loo yaqaan habka) neerfayaasha laftiisa ayaa quudiya laftiisa, abuurista wareegga dhaawaca joogtada ah, nafaqo-xumada, xanuunka neuroinflammation dheeraad ah, iyo arrimo kale oo ka dhigi kara. aad bay u adagtahay in la soo jeediyo kadib meel cayiman oo dhaawac ah. Haddii la ogolaado in aan la xakameynin waxay keeni kartaa dhaawac halis ah oo aan la hagaajin karin. Taasina waa sababta balooggani u dhawaaqo qaylo-dhaanta in ceeryaamo maskaxdu ay u baahan tahay in si dhab ah loo qaato oo lagu daaweeyo nafaqeynta iyo daawaynta maskaxeed ee xoogga leh ee joojisa sababaha asaasiga ah ee hababka neerfayaasha. Iyada oo aan loo eegin sabab ama ogaanshaha.
Sideen ku ogaan karaa in aan leeyahay maskax daadsan?
Waxaa jira calaamado ka hortag ah oo ka hortag ah oo la xidhiidha BBB Permeanability. Kuwaas waxaa ka mid ah S100B, Aquato 4, Qulqulka Fubillary Filillary Acid, iyo unugyada difaaca jirka ee zonulin. Xirfadlahaaga daawada ee hawsha ku shaqeeya ayaa ka dalban kara tijaabooyinka sidan oo kale ah iyada oo loo marayo sheybaarka Cyrus.
Waa lagu baari karaa, laakiin waa kan arrintu. Haddii aad og tahay in aad leedahay mindhicir soo daadanaya, ama lagaa helay mindhicir soo dareeray, markaa waxa jirta fursad aad u wanaagsan oo aad ku yeelan karto BBB. Sababtoo ah mindhicirka qulqulaya wuxuu u oggolaanayaa waxyaabo ay galaan dhiigga taas oo aan habboonayn. Waxyaalahaas qaarkoodna waa weerarro toos ah oo lagu qaado BBB. Xidhiidhka ka dhexeeya mindhicirka soo daadanaya iyo BBB-da daadsan waa mid aad u sarreeya. Way isla socdaan.
Tusaale ahaan, unugyada difaaca jirka ee ka soo horjeeda gluten, ee aan joojin BBB waxay ku xidhi karaan astrocytes iyo borotiinka neurofilament ee cerebellum waxayna keenaan xaalad loo yaqaan Gluten Ataxia. Nidaamka neurodegenerative ee u horseedaya ogaanshahan wuxuu u ekaan karaa calaamado ceeryaamo maskaxda ah oo ay ka mid yihiin dhibta hadalka, dareenka qallafsan ee cidhifyada, iskudubarid xumo iyo dheelitirnaan, iyo laga yaabee dhibaatooyinka isticmaalka gacmahaaga iyo lugaha ama farahaaga iyo gacmahaaga (tusaale, waxaad bilaabaysaa u fiirso dhibaatooyin badan oo farahaaga si ay u shaqeeyaan marka aad crochet).
Waxaa laga yaabaa inaad sun ku leedahay jirkaaga, ha ahaato soo-gaadhista kiimikaad ka timid alaab guri ama shay aad ka neefsatay deegaankaaga oo ku socda wadada (tani si joogto ah ayay u dhacdaa). Haddii BBB-gaagu caafimaad qabo, kuwani uma gudbi doonaan maskaxda. Laakiin haddii aysan caafimaad qabin, wax kasta oo walax ah ayaa u gudbi doonta maskaxda, iyada oo firfircoonaysa microglia oo sii daaya cytokines bararka.
Walxahaas aan la jeclayn ee ka sameeyay BBB-gaaga, oo aan meelna u dhowayn maskaxda, waxay isku xidhi doonaan oo ku xidhi doonaan borotiinno kala duwan waxayna jebin doonaan waxyaabo. Maxaan ula jeedaa "wax jebi" si sax ah? Waxaan ula jeedaa waxay ku xidhi doonaan meelaha waxyaabaha kale ee la rabay inay ku xidhaan, oo aan u oggolaan in wax si sax ah u shaqeeyo. Waxay geli doonaan jidka oo waxay joojin doonaan hababka muhiimka ah ee maskaxdaadu u baahan tahay si ay u shaqeyso oo ay maskaxdaada u ilaaliso.
Sida BBB-gaagu u dareeray
BBB-gaaga Asal ahaan waa unugyada ugu sareeya ee unugyada iyo astrogytes (astroglia). Labaduba kuwan ayaa si fudud loogu waxyeeleeyaa jawiga bararka dabadheeraad. Cudurrada daba-dheeraada ee kordhinta caabuqa jirka (oo ay u badan tahay in dhammaantood) ay door ka ciyaari karaan jebinta BBB. Qaar ka mid ah daawooyinka in dawada guud adeegsadaan daweynta cudurka daba-dheeraada waxay sababi kartaa burburin BBB (tusaale, corticosteroids). Waxay kaloo dhici kartaa natiijada dhaawaca maskaxda (TBI) (tusaale, shilalka gawaarida, dhicitaanka) maxaa yeelay BBB-ga ma ku filnaan karo inuu bogsiiyo ka dib markii laaslay. Dhibaatooyinka gubashada ee daba-dheeraada waxay abuuri karaan xaalad caabuq nidaam ah sababta oo ah daadinta xad-dhaafka ah (peremeaccack) sii daaya zonlin ama lipopolysaccharides (LPS) galay marinka dhiigga, oo markaa si toos ah caafimaadka u curyaamiya caafimaadka BBB.
Maxaa kale oo dhibaato u keena BBB-gayga?
Haddii aad leedahay heerar sare oo homocysteine ah baaritaanka dhiiggaaga, waxaad yeelanaysaa suurtogalnimo sare in BBB-gaagu soo daayo. Haddii aad leedahay SNP-yada hidde sida MTHFR, waxaad halis sare ugu jirtaa dhibaatooyinka ilaalinta BBB-gaaga mid ilaalin iyo caafimaad leh. Waxaad hagaajin kartaa jaanisyada adiga oo qaadanaya methylated B-complex.
Waxyaalaha kale ee abuura sii wadida BBB waxaa ka mid ah kuwan soo socda:
- Hab-nololeedka ku-meel-gaadhka ah
- Isticmaalka khamriga
- Hurdo la'aan joogto ah
Waxaa laga yaabaa inaad jeceshahay inaad ogaato waxa la samayn karo si loo hagaajiyo.
Sida cuntooyinka ketogenic ay u caawin karaan inay bogsiiso maskaxda soo daadanaya
Inta badan macluumaadkayaga ku saabsan sida ketones u saameeyaan BBB waxay ka yimaadaan daraasadaha xayawaanka. Shakhsi ahaan, waan ka nastay taas. Ma doonayo in qof madaxa ka gooyo qof isku dayaya inuu ogaado waxa meeshaas ka socda. Markaa ha ku xidhin fikradda ah sababta oo ah kuwani waxay ka yimaadeen daraasado xayawaan ah si uun natiijadu maaha mid sharci ah BBB-gaaga. Mashiinno badan oo isku mid ah ayaa socda.
Maskaxda oo hagaagtay iyo dheef-shiid kiimikaad BBB
Marka jidhkaagu uu ketones ku samaynayo cunto ketogenic ah, waxay ku siin kartaa ilo tamar kale oo loogu talagalay BBB-ga dhaawacan. Waxay kaliya u dhacaan inay noqdaan isha shidaalka ee la door biday maskaxda. Waxay galaan maskaxda iyaga oo aan buuq lahayn ama muuska u baahan gaadiid farxad leh ama shaqeeya (tusaale, fidin fudud ama fidin fudud). Gaadiidleyda Monocarboxylate waxay dhexdhexaadiyaan gelitaanka jidhka ketone ee maskaxda, waxayna aad ugu badan yihiin dhammaan BBB-da, oo ay ku jiraan xuubka plasma ee plexus choroid, unugyada endothelial iyo epithelial, glia, iyo neurons. Dhab ahaan, oodles siyaabo aad ku heli karto ketones halkaas si ay u huriyaan maskaxdaada. Ketones-kaas waxaa loo adeegsadaa matrixka mitochondrial (xuubka ku jira baytariyada unugga) kaas oo tamar sameeya.
Oo halkan waa waxa aan u baahanahay inaad sidoo kale hesho. BBB sidoo kale waxay isticmaashaa tamarta ketones-ka. Unugyadaas yaryar ee ka kooban BBB waxay isku dayaan inay samaystaan tamarta ketone-ku-salaysan mar walba. Oo haddii aad ku jirto cunto ketogenic unugyadu waxay ku buuxin doonaan tamarta ay u baahan yihiin si ay u xoojiyaan isgoysyada loo baahan yahay si ay BBB-du u ahaato mid xooggan oo aan hagaagsanayn.
Miyaan sheegay in maskaxdu ay u baahan tahay tamar badan? Aad u fiican in ay jirto hab lagu helo tamarta ay u baahan tahay oo aan u baahnayn dadaal dheeraad ah. Sax? Waa nooc ka mid ah sida socodka dakhliga dadban halkii aad ka iibsan lahayd dhaqanka degdega ah. Waxaan ula jeedaa, waxaan heli karnaa kuwa qaata GLUT oo shaqeeya mar kale aakhirka marka bogsashadu sii socoto. Laakiin waligeen horumar uma soconeyno bogsashadayada haddii aan gaajo u gaajono maskaxda inta ka horeysa. Waxay kaliya u socotaa inay sii wado hababka neurodegenerative ee socda. Gunno ahaan, jirka ketone sidoo kale wuxuu si toos ah u wanaajiyaa dhaqdhaqaaqa GLUT1, GLUT1 waa gaadiid qaada ka caawiya gulukoosta inay gaarto halka ay iska leedahay.
Ketones-ku waa anti-bararka
Kaliya ma lihin daawo ah oo bixiya isla heerka saameynta anti-bararka ah ama wax ku ool ah sida cuntada ketogenic ah.
Waxtarka daweynta ee dawooyinka anti-neuroinflammatory-ka ee ballaaran ayaa xaddidan saameyntooda ka dib xitaa xakameynta difaaca jirka.
JANIGRO, D. (2022). Saamaynta Cunnooyinka Ketogenic ee Dhiiga-Maskaxda. Cuntada Ketogenic iyo Daaweynta dheef-shiid kiimikaadka: Doorarka Balaadhan ee Caafimaadka iyo Cudurada, 346. P.355
Marka uu jiro firfircooni difaac joogto ah waxaa jira dhaawac maskaxda ku dhaca iyo BBB. Tani waxay u keentaa barar iyo walbahaar dheeraad ah oo jidhka ah oo isku dayaya inuu ilaaliyo isku-xidhka adag ee BBB. Caabuqani wuxuu dhaawici karaa dhismayaasha muhiimka ah ee xididdada dhiigga ee qayb ka ah BBB. Waxay dhaawici kartaa glial iyo astrocytes. Cuntooyinka ketogenic waxay hoos u dhigaan bararka. Ketones-ka lagu soo saaro cuntada ketogenic waxay u dhaqmaan sida unugyada calaamadaha, oo si dhab ah u sheegaya hiddo-wadaha ku lug leh bararka dabadheeraad ah si ay naftooda u damiyaan. Aad bay waxtar u leedahay caawinta in yar oo BBB ah si ay ula qabsato dayactirka, ilaaliso daacadnimadeeda iyo shaqadeeda, oo ay sii wado bogsiinteeda haddii aad i weydiiso.
Hadda dib ugu noqo dhismayaasha xididdada dhiigga. Waxaa jira asaasaqa badan oo leh qaybaha cudurrada xididdada dhiigga. Ketones waxay kordhiyaan kor u qaadista socodka dhiigga maskaxda iyo tan korodhka socodka dhiigga iyo isticmaalka oksijiinta ayaa loo maleynayaa inay gacan ka geysato saameynta si fiican loo diiwaangeliyay ee neerfaha ee jirka ketone. BBB daadanaya waa arrin etiological asaasaqa qaarkood (tusaale, Alzheimers) waxaana loo malaynayaa in faa'iidooyinka lagu arkay cuntooyinka ketogenic ee dadkan laga yaabo inay qayb ahaan sabab u tahay shaqada BBB oo soo hagaagtay. Mala-awaalka ah in ketones uu hagaajiyo shaqada neerfaha ee waallida waa aagga hadda jira ee daraasadda cilmi-baarista.
Sida haddii waxaas oo dhami aanay ku filnayn isticmaalka cuntada ketogenic si ay u caawiso bogsiinta maskaxda ee daadanaya, ketones waxay gacan ka geystaan abuurista borotiinno badan oo BBB ah si ay u bogsiiso meelaha bannaan ee dillaacay, si ay u bilaabaan.
Xulashada Kaabista
Sababtoo ah waxaan aaminsanahay inaad xaq u leedahay inaad ogaato dhammaan siyaabaha aad ku dareemi karto fiicnaan, waxaan doonayaa inaan liis gareeyo qaar ka mid ah kaabisyada la isticmaalo kuwaas oo leh heerar kala duwan oo caddayn ah hagaajinta BBB. Laakiin aan si fiican u caddeeyo in aanan u malaynayn in ay tani meel u dhow sida qabow ama waxtar u leh bogsashada BBB sida cunto ketogenic si fiican loo habeeyey. Kuwaas midkoodna ma bogsado caabbinta insulin. Midkoodna ma aha ilo kale oo shidaalka maskaxda. Qaar ka mid ah kuwan waxay wanaajin karaan shaqada iyo socodka dhiigga ee unugyada epithelial iyo endothelial, qaarna waxay ku siin karaan qaar ka mid ah ficilka antioxidant-ka ee la hagaajiyay si aad isku daydo inaad la qabsato diiqada oksida.
Ma ka heli doontaa xoogaa bogsasho BBB ah kaaboyinkan? Haa, waa laga yaabaa. Ilaa iyo inta cascade neurodegenerative ee aad ku socoto ma laha dardar aad u badan. Laakin haddii ay suurtogalka BBB ka timaad istaroog ama TBI, ama hababka asaasaqa hore, kuwani ma bixiyaan ilaha shidaalka saxda ah ee maskaxdaadu u baahan tahay si ay ula dagaallanto hypometabolism maskaxda. Kaabayaashani ma bixiyaan nafaqeeyayaalka yar yar ee la hagaajiyay ama xitaa nafaqeeyayaalka yar yar ee dayactirka iyo hagaajinta maskaxda iyo shaqada BBB ee la hagaajiyay.
Haddii ay dhab ka tahay bogsashada maskaxdaada, ha ka baqin inaad sameyso waxa aad male-awaalayso oo runtii adag. Waxaan kuu ballan qaadayaa, in barashada sida loo hirgeliyo loona joogteeyo cuntada ketogenic ayan ugu dhowaan sida ay u adag tahay in la haysto maskax aan shaqaynayn. Maskax kaa ilaalinaysa inaad nolosha si buuxda ugu raaxaysato.
Maskaxda ku jirta murugo joogto ah oo leh arrimaha niyadda iyo dhibaatooyinka xusuusta?
TAAS WAA ADAG. Mid kasta. Hal. Maalinta
Cunto ketogenic ah waa qalooc waxbarasho oo waxaad mudan tahay in lagaa taageero hirgelinta. Laakiin waxaan kuu ballan qaadayaa, adigoo ah qof maskaxdayda soo kabtay, uma dhowa sida aad u malaynayso. Waxaad mar hore maraysaa mid ka mid ah waxyaalihii ugu adkaa. Cuntooyinka ketogenic way fududahay marka la barbardhigo.
Kaabayaasha caawin kara hagaajinta BBB waxaa ka mid ah saliidaha kalluunka, Ginko Bilboa, vinpocetine, alfa-lipoic acid, glutathione (hel liposomal ama horudhac muhiim ah, baro sababta halkan), iyo resveratrol.
Mararka qaarkood waxaan u isticmaali doonaa qaar ka mid ah kuwan marka lagu daro cuntada ketogenic sida daawaynta isku dhafan, laakiin ma isticmaalo iyaga si aan u bogsiiyo BBBs ama qaybaha kale ee maskaxda. Oo sidaas daraaddeed, ma garanayo qiyaasta saxda ah ee ay dadku isticmaalaan haddii ay kuwan u isticmaalayaan sida daaweynta aasaasiga ah ujeedadan. Laakiin mar labaad, waxaad awoodi doontaa inaad u baari karto doorsoomayaashaas bogsashadaada.
Ugu Dambeyn
Barnaamijka Soo kabashada Fog ee Maskaxda waxaan ku baraa, waxaan isticmaalnaa cuntooyinka ketogenic, kaabis nafaqeed shakhsi ahaan la hagaajiyay, iyo tababarida ku wajahan waxqabadyada daawaynta ee ka caawiya daawaynta BBB-da daadsan oo dadka ka caawiya inay ku noolaadaan noloshooda aadka ugu fiican. Sababtoo ah aan daacad ka nahay. Sideed u aragtaa nolosha? Iyadoo maskaxdaada loo marayo. Uma baahnid inaad la noolaato calaamadaha ceeryaamo maskaxda, iyadoon loo eegin sabab ama ogaanshaha. Sababtoo ah dhakhtarkaagu wuu iska indhatiray cabashadaada ku saabsan awood la'aantaada inaad diirada saarto, xasuusato waxyaalaha, ama xajiso niyadaada macnaheedu maaha inaysan jirin daaweyn wax ku ool ah.
Waan ku faraxsanahay inaan kaa caawiyo inaad barato dhammaan dariiqooyinka aad dareemi karto fiicnaan!
tixraacyada
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