Glutathione iyo cuntada ketogenic
Sidee bay kor u qaadida cuntada ketogenic ee glutathione qayb uga ciyaartaa ka bogsashada maskaxdaada jirrooyinka dhimirka iyo xanuunada neerfaha?
Glutathione waa nidaamka antioxidant ee ugu weyn ee maskaxda. Awoodda cuntada ketogenic ee lagu hagaajinayo wax soo saarka glutathione ayaa si gaar ah waxtar u leh dadka qaba cudurrada dhimirka ama cilladaha neerfaha. Cuntooyinka ketogenic waxay kordhiyaan soosaarka glutathione ee maskaxda. Hababka kale ee glutathione ay ku daweyso jirrooyinka dhimirka iyo arrimaha neerfaha ayaa ah dayactirka mindhicirka qulqulaya, hoos u dhigista bararka maskaxda iyada oo loo marayo hagaajinta habka difaaca jirka ee macrophages, hagaajinta hagaajinta xannibaadda dhiigga-maskaxda (BBB). Kor u qaadida wax soo saarka glutathione waxa kale oo ay wanaajisaa shaqada beerka, taas oo yaraynaysa culayska weerarada jidhka oo hadhow wiiqi kara shaqada maskaxda (tusaale, biraha culus, xenoestrogens).
Hordhac
Haddii aad wax badan ka akhriday blog-kan, waxaad ka baratay caabuqa iyo walbahaarka oksaydhka, iyo sida ay u abuuri karaan calaamadaha cudurrada dhimirka iyo xanuunada neerfaha. Waxa kale oo laga yaabaa inaad akhriday waxa aan ka qoray nidaamka la yaabka leh ee anti-oxidant ee aad ku leedahay jidhkaaga kaas oo ka caawiya la dagaalanka bararka iyo walbahaarka oksaydhka. Tani endogenous (jirkaaga ayaa ka dhigaya!) Antioxidant waa glutathione wax soo saarkaaga glutathione waa la kordhiyaa markaad tagto cunto ketogenic ah.
Boostada ayaa ka hadli doonta sababta kor u qaadida glutathione ee aad ka hesho cuntada ketogenic ay aad muhiim ugu tahay daaweynta cudurkaaga dhimirka ama arrimaha neerfaha. Waxaan si gaar ah uga hadli doonaa sababta cuntada ketogenic ay u leedahay inay hagaajiso glutathione waa mid ka mid ah siyaabaha ugu waaweyn ee ay uga caawiso daaweynta calaamadahaaga.
Qoraalada kale ee blog-ka (soo socda!) Waxay ka wadahadli doonaan waxa glutathione yahay, sida loo sameeyo jidhkaaga, iyo waxa aad samayn karto si aad u kordhiso wax soo saarka glutathione-kaaga kaas oo kor u qaadi doona saameynta horeba bogsashada ee cuntadaada ketogenic ee xanuunka dhimirka.
Laakiin marka hore, aan ka hadalno sababta aad ugu baahan tahay glutathione kor u kac ah ee aad ka hesho cuntada ketogenic, gaar ahaan si aad u daweyso cudurkaaga dhimirka oo aad hoos u dhigto calaamadahaaga.
Glutathione waxay bogsiisaa mindhicirkaaga Leaky.
Waxaa laga yaabaa inaad ku bilawday cuntadaada ketogenic arrimo dheefshiidka oo darnaan kala duwan leh. Marka ay daraaseeyaan dadka qaba xanuunka mindhicirka, waxay arkaan calaamado muujinaya in glutathione ay yaraatay. Tani waxay u badan tahay sababtoo ah si joogto ah ayaa loo dhammeeyaa dadaalkeeda si loola dagaallamo cadaadiska oksaydhka ee mindhicirka.
Ka soo qaad in aysan jirin glutathione ku filan si loo yareeyo bararka iyo la dagaallanka diiqada oksaydhka. Xaaladdaas, waxaad heleysaa dhaawaca unugga, kaas oo ku siinaya calaamadaha dheefshiidka ee xun. Marka heerka glutathione uu hoos u dhaco, mindhicirku isma hagaajin karo, oo noqda mid dareere ah. Mindhicirku ka daadanayo wuxuu hawlgeliyaa habka difaaca jidhkaaga, wuxuu kordhiyaa dhaqdhaqaaqa difaaca maskaxda iyo caabuqa neuroinflammation.
Neuroinflammation waa qodobka hoose ee pathology ee jirro kasta oo dhimir ah oo aan wax kaga qoray boggan ilaa hadda. Dhammaanteen waan ognahay in caafimaadka mindhicirkeena uu saameeya caafimaadka maskaxda iyo niyadda.
Markaa intaad ku jirto cuntadaada ketogenic iyo glutathione-kaaga la hagaajinayo, waxaad hoos u dhigi doontaa diiqada oksaydhka ee mindhicirkaaga. Taasi waxay kaa caawin doontaa in mindhicirku bogsado (ugu dambeyntii) oo, iyaduna, hoos u dhigto xanuunka neuroinflammation iyo cadaadiska oksaydhiyaha ee maskaxdaada. Taasina waa mid ka mid ah siyaabaha cuntada ketogenic ay kaa caawin doonto inaad daaweyso cudurkaaga dhimirka.
Glutathione iyo habka difaacaaga
Dadka ku jira cuntada ketogenic waxay sheegaan inay aad uga yar yihiin jirrooyinka oo ay ku dhacaan cudurro aan badnayn. Waxaa laga yaabaa inaad is weydiiso waxa ay taasi ku saabsan tahay. Waxaa jira siyaabo badan oo muhiim ah oo cuntada ketogenic ay wanaajiso shaqada habka difaaca jirka. Laakiin gaar ahaan sida cuntada ketogenic u kordhiso glutathione iyo sida wax soo saarka glutathione ee wanaajiyay ay kor ugu qaaddo nidaamka difaaca, waxaan u baahanahay inaan ka hadalno macrophages. Glutathione ku filan ayaa loo baahan yahay si ay unugyada dhiigga cad (macrophages) ka dhigaan qayb muhiim ah oo ka mid ah habka difaaca jirka.
Makrophages caafimaad qaba oo tiro ku filan ayaa soo saara difaac degdeg ah oo muhiim u ah weerarka bakteeriyada iyo fayraska. Waxaad doonaysaa fal-celin difaac adag, degdeg ah, iyo burburinta kuwa soo duulay. Waxa aadan rabin waa dagaal dheer, soo baxay, oo aan waxtar lahayn kaas oo ilaalinaya cytokines bararka oo sii wada abuurista bararka maskaxda muddo dheer.
Glutathione iyo xannibaadda maskaxdaada ee dhiigga
Waxa laga yaabaa in xannibaadda dhiiga-maskaxdaadu ay si fiican u daadato haddii aad ka cabanayso jirro maskaxeed ama cillad neerfaha ah. Tanina waa dhibaato aad u weyn. Waxaad u baahan tahay in xannibaadda dhiigga-maskaxdu ay hagaagto oo si fiican u shaqeyso si aad maskaxdaada uga ilaaliso sunta. Haddii kale, molecules aan waligood loo malaynaynin inay u soo dhowaadaan maskaxdaada ayaa sidaas sameeya. Tani waxay kicisaa jawaab celin difaac maskaxdaada si ay ula dagaallanto molecules-yada aan ahayn inay halkaas joogaan. Jawaabta difaaca ee maskaxdaada waxay soo saartaa cytokines bararka. Cytokines-yadani waxay soo saaraan dhaawaca gacanta marka ay isku dayayaan inay la dagaalamaan khatarta. Taas oo fiicnaan lahayd haddii aynaan lahayn qulqulo joogto ah oo ah unugyo maskaxda soo gala oo aan ahayn inay halkaas joogaan sababtoo ah xannibaadda dhiigga-maskaxda oo sii socota. Xanuunka neuroinflammation-ka ee daba-dheeraada ee ka dhasha hab-dhiska difaaca maskaxda oo aan joogsi lahayn sababta oo ah xannibaadda dhiigga-maskaxdaada ee dillaacsan ayaa ah sababta asaasiga ah ee calaamadahaaga.
Waa sidaas oo kale in cuntooyinka ketogenic ay kor u qaadaan hagaajinta iyo dayactirka xannibaadda dhiigga-maskaxda siyaabo kala duwan. Marka hore, waxay wanaajiyaan abuurista isgoysyo fiican oo cidhiidhi ah, taas oo ah qayb ka mid ah BBB oo noqota dareere. Cuntooyinka ketogenic waxay sidoo kale kordhiyaan wax soo saarka tamarta ee astrocytes, taas oo ah mid ka mid ah unugyada neerfayaasha asaasiga ah ee mas'uulka ka ah caafimaadka BBB.
Markaa, saamaynta faa'iidada leh ee cuntada ketogenic waxay ku xirnaan kartaa korodhka kor u kaca maskaxda ee [jidhka ketone] KBs si loo waafajiyo baahida dheef-shiid kiimikaad iyo hagaajinta khalkhalka [dhiig-maskaxda] BBB.
CellKBs waxay hagaajiyaan guuritaanka unugga iyo muujinta borotiinnada isku dhafka ah ee Banjara, M., & Janigro, D. (2016). Saamaynta cuntada ketogenic ku leedahay xannibaadda dhiigga-maskaxda. KCunto etogenic ah iyo Daaweynta dheef-shiid kiimikaadka: Doorarka Balaadhan ee Caafimaadka iyo Cudurrada; Susan, AM, Ed, 289-304. DI: 10.1093/med/9780190497996.001.0001
Kordhinta glutathione ee cuntada ketogenic waxay caawisaa ilaalinta iyo hagaajinta xannibaadda dhiigga-maskaxda.
Glutathione iyo beerkaaga
Beerkaagu kama saari karo jidhkaaga weerarrada deegaanka iyada oo aan la helin heerar ku filan oo glutathione ah. Weerarada deegaanka ee aan la xakamayn, iyada oo aan loo eegin in ay ka gudbaan xannibaadda maskaxdaada iyo in kale, waxay abuuri karaan caabuqa neuroinflammation.
Beerku wuxuu u baahan yahay glutathione si ay kaaga caawiso sunta ka hortagayaasha soo socda si ay u noqoto caafimaadka maskaxdaada. Mid kasta oo kuwan ka mid ah wuxuu u qalmaa qoraal gaar ah si uu u sharaxo sida ay uga qaybqaataan horumarinta cudurrada dhimirka.
- metabolites daroogada
- mycotoxins
- macdanaha culus
- sunta cayayaanka
- doogga xoolaha
- xenoestrogens
Waxaad u baahan tahay kor u qaadida glutathione ee ku dhacda cuntada ketogenic si aad uga caawiso jirkaaga inuu ka saaro waxyaabaha wax u dhimaya caafimaadka maskaxdaada oo uu abuuro calaamadahaaga.
Glutathione iyo maskaxdaada
Aan si fiican u caddeeyo. Glutathione waa Kahortagaha ugu weyn oo ay maskaxdaadu isticmaasho si ay u ilaaliso caafimaadka iyo shaqada. Ma aha Faytamiin C mana aha Faytamiin E, in kasta oo kuwa loo isticmaalo sidii cofactors si loo sameeyo glutathione. Haddii aad rabto maskax caafimaad qabta, waxaad u baahan tahay glutathione inta uu jirkaagu rabo inuu soo saaro si uu uga ilaaliyo oo uga hagaajiyo neerfayaasha waxyeellada.
Ka soo qaad inaad qabtid jirro maskaxeed ama cillad neerfaha. Xaaladdaas, waxay u badan tahay inaad leedahay qaybo maskaxdaada ka mid ah oo ay ku yar tahay glutathione. Qaar ka mid ah meelaha maskaxda laga helay inay si gaar ah ugu hooseeyaan glutathione ee cilladaha gaarka ah waxaa ka mid ah kuwan soo socda:
- Kortex hoose ee xingulate-ka dambe ee xanuunka waswaaska ah (OCD)
- Substantia nigra ee Cudurka Parkinson (PD)
- Kortex occipital iyo prefrontal ee niyad-jabka
- Kortex hore ee xanuunka laba-cirifoodka iyo schizophrenia
Kordhinta wax soo saarka glutathione waxay kaa caawin kartaa la dagaalanka diiqada oksaydhka qaybo gaar ah oo maskaxda ah oo khuseeya ogaanshahaaga gaarka ah. Markaas waxaa suurtogal ah in la yareeyo calaamadahaaga.
Xitaa haddii heerarka glutathione ee hoos u dhacay aan laga helin qaababka maskaxda ee gaarka ah ee xanuunkaaga, waxaa jira fikrad guud oo suugaanta ah oo ku saabsan in cudurrada dhimirka iyo neerfayaasha ay kordhiyeen heerarka cadaadiska oksaydhka iyo heerarka glutathione ee guud ahaan.
Glutathione (GSH) ayaa la odhan karaa waa antioxidant-ka ugu muhiimsan ee maskaxda. Sanadihii la soo dhaafay, heerarka GSH-ga aberrant ayaa lagu lug yeeshay xanuunada dhimirka ee kala duwan, oo ay ku jiraan cudurada nafsaaniga ah ee la xiriira walaaca.
Zalachoras, I., Hollis, F., Ramos-Fernández, E., Trovo, L., Sonnay, S., Geiser, E., Preitner, N., Steiner, P., Sandi, C., & Morató, L. (2020). Awoodda daweynta ee glutathione-kor u qaadayaasha ee cudurrada nafsaaniga ah ee la xidhiidha walaaca. Dib u eegida neerfiyoolojiga iyo dib-u-eegista noolaha, 114, 134-155. https://doi.org/10.1016/j.neubiorev.2020.03.015
Markaa, isticmaalka cuntada ketogenic si loo kordhiyo heerarka glutathione ee maskaxda gaar ahaan waa mid ka mid ah hababka ay ku tahay daawaynta suurtagalka ah ee saxda ah ee jirrada dhimirka ama xanuunka neerfaha.
Ugu Dambeyn
Waxaa jira faa'iidooyin badan oo loogu talagalay qof la halgamaya cudurka dhimirka ama calaamadaha neerfaha si uu u kordhiyo wax soo saarka glutathione. Oo ketogenic si sax ah ayuu u sameeyaa!
Hadda, waxaa laga yaabaa inaad leedahay xoogaa kala duwanaansho hidde-side ah kuwaas oo farageliya awooddaada inaad sameyso oo dib u warshadayn glutathione. Waxaa laga yaabaa inay kugu adkaato inaad sameyso, taasina waxay ku caawin lahayd inaad ogaato. Haddii aad rabto inaad si qoto dheer u dhex gasho awoodda jidhkaaga si uu u sameeyo glutathione, waxaan kugula talin lahaa inaad tijaabiso 23andMe (xiriirka xiriirka). Xusuusnow, qayb ka mid ah 23andMe waxaa lagu bixin karaa koontadaada kaydka caafimaadka (HSA) ama (FSA) haddii aad faa'iidadaas leedahay.
Markaad haysatid taada 23andMe xogta aad iska qori kartaa website-kan cajiib ah Hacks Life Hidde (xidhiidh la leh) kaas oo lafaguri doona oo ka warbixin doona sida wanaagsan ee hiddo-wadahaagu u taageeraan awoodaada inaad sameyso oo dib u isticmaasho antioxidant-ka muhiimka ah ee maskaxdaada bogsiinaya si xun bay ugu baahan tahay!
Wax kasta oo aad ogaato, ha quusan. Waxaa jira waxyaabo aan sameyn karno si aan u kordhino wax soo saarkaaga glutathione, xitaa cuntada ketogenic, taas oo qabta shaqo aad u fiican oo samaynta wax badan oo ka mid ah meesha ugu horeysa.
Waxaad u baahan tahay inaad akhrido maqaalkan ku saabsan yaraanta thiamine sababtoo ah yaraanta thiamine waxay kaa hor istaagi kartaa awooddaada inaad sameyso glutathione. Waxaana laga yaabaa inaad gelayso cuntadaada ketogenic yaraan thiamine!
Hubi inaad hesho magnesium badan, maadaama ay taasi kiciso thiamine, markaa waxay samayn kartaa shaygeeda si ay uga caawiso samaynta glutathione.
Haddii aad u aragtay maqaalkan kor ku xusan inuu waxtar leeyahay, waxa kale oo aad jeclaan kartaa barta kale ee blog-ka ee ka hadlaysa glutathione.
Waxaan ahay lataliye caafimaadka dhimirka oo ku dhaqma mabaadi'da cilmi nafsiga ee shaqeynaya iyo nafaqeynta. Waxaan sameeyay barnaamij online ah macalin ahaan iyo tababare caafimaad oo shaqaynaya si aan si wanaagsan ugu adeego dadweynaha, isku dayo inaan barto sida ay u dareemi karaan fiicnaan. Waxaad ka baran kartaa wax badan oo ku saabsan Barnaamijka Soo kabashada Fog Maskaxda hoos:
Ma jeceshahay waxa aad ka akhrinayso blog-ka? Ma doonaysaa inaad wax ka barato webinars soo socda, koorsooyin, iyo xataa waxay bixisaa taageero iyo ila shaqaynta xagga yoolalkaaga fayoobi? Isdiiwaangeli!
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