Cuntooyinka Ketogenic ee Cudurka Matterka
Waqtiga akhriska ee la qiyaasay: 8 daqiiqo
Maskaxdu waxay inta badan ka kooban tahay maadada cawl iyo maaddada cad. Maaddada cawlku waxay dabooshaa bannaanka maskaxdeenna, taas oo loo yaqaan kortex, oo macneheedu yahay jilif. Maaddada cad waxay u badan tahay gudaha. Maaddada cad waxay ka kooban tahay fiilooyinka neerfaha ee isku xira qaybaha kala duwan ee maskaxda, waxaana lagu daboolay galka myelin. Galkan difaaca ayaa u muuqda caddaan sababtoo ah wuxuu ka kooban yahay baruur, iyo dhowr nooc oo kale oo unugyo ah. Walaxda cad doorkeedu waa in ay soo gudbiso xogta oo ay ka guurto qayb maskaxda ka mid ah una guurto qayb kale.
Cudurka maskaxda ee ischaemic ee joogtada ah, CNS cudurrada maraakiibta yaryar, leukoaraiosis, hyperintensities walxaha cad, lesions cadadka cad, lacunar infarcts, cudurada microvascular, ama cudurrada maraakiibta yaryar waa magacyo isku mid ah. Dhammaantood waa cudurro cadcad.
Maxaa keena Cudurka Maaddada Cad?
Cudurka cadaanka ahi waxa uu ka dhigan yahay in xididada dhiiga ee keena cadada ay xidhmeen, jabeen, ama ay barareen cadaadis, taasoo keentay in ay ku filnaato ogsijiin iyo nafaqeeyayaalka yar yar ee unugyada dareemayaasha. Xididdada dhiigga ee yaryar ayaa dhintaan, kuwaas oo yareeya ama gebi ahaanba baabi'iya isha tamarta ee unugyada maskaxda ee ay bixiyaan xididdada dhiigga ee gaarka ah. Cudurka cad-cadka waa erey tilmaamaya dhaawaca soo noqnoqda ee qayb gaar ah oo maskaxda ah oo ay sababto socodka dhiigga oo yaraada.
Maskaxda dhexdeeda, waxyaabahani waxay caadi ahaan ka dhacaan meelaha bannaan, oo ah xudunta maskaxda. Sababta tani waa in xididdada dhiigga ee qaybtan maskaxda ay leeyihiin dhexroorka ugu yar, oo yar sida xadhig timo ah. Sidaa darteed, xitaa qadar yar oo dhaawac ah oo aaggan ah ayaa keeni kara arrimo. Caabuqa ayaa keena dhaawacan.
Maxaa keena caabuqa neuroinflammation?
Qaybaha cusub ee shaqaynta ee microglia ayaa la ogaaday inay gacan ka geystaan jawaabta arrinta cad ee bilawga iyo horumarka cudurka CNS. Microglia waxay muujisaa qaabab molecular oo kala duwan iyo qaab-dhismeedka iyadoo ku xiran nooca cudurka iyo gobolka maskaxda, gaar ahaan walxaha cad. Marxaladaha dambe ee cudurka, microglia-ka xad-dhaafka ah ayaa sii wadi kara horumarka cudurka ee cudurada cadaanka ah iyada oo loo marayo pro-bararka, oxidative, iyo saamaynta excitotoxic, wax u dhimaya dayactirka myelin iyo kicinta neurodegeneration.
Aan tusaale ka bixiyo sida ay tani u egtahay. Qaar ka mid ah microglia ayaa lagu dhejiyaa baabuurka xad-dhaafka ah ee jawi barar badan waxayna bilaabaan inay hoos u dhigaan waxyaabaha aysan ahayn. Waxay bilaabaan inay dilaan (phagocytosis) unugyo iyo dhismayaal aan weli dhiman. Qaar ka mid ah waa myelin oo ku jira walxaha cad. Haddii aan qaboojin lahayn habka difaaca jirka, wax badan oo myelin ah ayaa la badbaadin lahaa.
Ma garanaysaa waxa ka dhigaya microglia farxad, degenaansho, iyo shaqeyn? Cunto ketogenic ah. Ma u malaynaysaa inaan alaabtan samaynayo? Ma ihi Sii wad akhriska.
Sidee cunnada ketogenic u caawin kartaa dhimista caabuqa neuroinflammation ee keenaya cudurka White Matter?
Daraasaddan, cilmi-baarayaashu waxay sahamiyeen saameynta daaweynta ee cuntada ketogenic (KD) ee dabeecadaha niyad-jabka ah ee moodooyinka jiirka. Natiijooyinka ayaa shaaca ka qaaday in cuntada ketogenic ay si weyn u wanaajisay dabeecadaha niyad-jabka oo kale ah. Waxay soo sheegeen in calaamadaha ay u badan tahay in la dhexdhexaadiyo iyada oo loo marayo dib u soo celinta firfircoonida bararka microglial iyo dareenka neerfaha.
Isku soo wada duuboo, waxaan soo bandhignay saameynta daaweynta ee KD ee dabeecadaha niyad-jabka ah, kuwaas oo laga yaabo in lagu dhexdhexaadiyo iyada oo loo marayo soo celinta firfircoonida bararka microglial iyo kicinta neerfaha.
Guan, YF, Huang, GB, Xu, MD, Gao, F., Lin, S., Huang, J., … & Sun, XD (2020). Saamaynta ka-hortagga niyad-jabka ee cuntada ketogenic waxaa lagu dhexdhexaadiyaa iyada oo loo marayo dib-u-soo-celinta firfircoonida microglial iyo dareenka neerfaha ee habenula lateral. Maskaxda, Dabeecadda, iyo Xasaanadda, 88, 748-762. https://doi.org/10.1016/j.bbi.2020.05.032
Daraasaddan soo socota, cilmi-baarayaashu waxay eegeen saameynta ilaalinta iyo ka hortagga bararka ee cuntada ketogenic ee qaabka jiirka ee cudurka Parkinson. Waxay isticmaaleen neurotoxin kaas oo si door ah u baabi'iya neerfaha dopaminergic ee ku jira substantia nigra, oo ah gobolka maskaxda ee ku lug leh xakameynta dhaqdhaqaaqa. Dhaawaca ka dhasha neerfayaashan ayaa horseeda in dhaqdhaqaaqa dhaqdhaqaaqa iyo calaamado kale oo aad ugu dhow cudurka Parkinson ee aadanaha. Natiijooyinku waxay muujiyeen in markii jiirarka la siiyay cuntada ketogenic ka hor inta aan la soo bandhigin neurotoxin, dhibaatooyinkooda dhaqdhaqaaqa ayaa soo fiicnaaday. Cuntadu waxay sidoo kale ka caawisay ilaalinta unugyada maskaxda ee ka masuulka ah soo saarista dopamine, kaas oo sida caadiga ah waxyeello u leh cudurka Parkinson. Cunnada ketogenic waxay hoos u dhigtay firfircoonida unugyada difaaca qaar ka mid ah maskaxda (microglia) ee maskaxda waxayna hoos u dhigtay heerarka caabuqa keena molecules (cytokines proinflammatory) ee aagga ay dhibaatadu saameysey.
Xogtu waxay tustay in daawayntii hore ee KD ay yaraysay shaqa xumada ay keentay MPTP (neurotoxin).
Yang, X., & Cheng, B. (2010). Dhaqdhaqaaqyada ka hortagga neuroprotective iyo ka-hortagga-bararka ee cuntada ketogenic ee MPTP-ku-soo-baxa neurotoxicity. Wargeyska molecular neuroscience, 42, 145-153. https://doi.org/10.1007/s12031-010-9336-y
Dib-u-eegis dhamaystiran oo soo socota waxay ku qotontaa hababka molecular ee xakameynaya sida microglia, unugyada difaaca maskaxda, u dhaqmaan siyaabo kala duwan. Microglia waxay qaadan kartaa khataro, barar sababa gobolo ama caawimo, gobolo la dagaalanka caabuqa ee ilaaliya maskaxda. Dib-u-eegistu waxay sidoo kale baari doontaa xog badan oo ah xogta saxda ah, taas oo soo jeedinaysa in ka dib cuntada ketogenic (KD) ay u horseedi karto isbeddello faa'iido leh oo isdaba-joog ah oo ku yimaada unugyada microglial.
Isbeddelladani waxay u muuqdaan inay ka soo jeedaan xannibaadda waddooyinka kuwaas oo haddii kale u riixaya microglia dhinaca waxyeellada, dawladaha bararka. Marka sidaas la sameeyo, cuntada ketogenic waxay kor u qaadi kartaa waxtar leh, dawladaha ka hortagga bararka ee microglia, taas oo ugu dambeyntii ka faa'iideysan karta shakhsiyaadka leh xaalado kala duwan oo neerfaha.
Intaa waxaa dheer, xogo badan oo sax ah oo kala duwan ayaa muujinaya in ka dib KD ay habraac habaysan ay ka dhacaan unugyada microglial-ka. Hababkaasi waxay u muuqdaan inay keenaan joojinta dariiqyada xukuma iibka iyo dayactirka dawladaha / phenotypes-yada u badan-bararka.
Morris, G., Puri, BK, Maes, M., Saytuun, L., Berk, M., & Carvalho, AF (2020). Doorka microglia ee xanuunada neuroprogressive: hababka iyo saamaynta neurotherapeutic ee suurtogalka ah ee ketosis-ka. Horumar xagga cilmu-nafsiga iyo cilmu-nafsiga, 99, 109858. https://doi.org/10.1016/j.pnpbp.2020.109858
Waan ka xumahay. Ma u baahan tahay caddayn cilmiyaysan oo dheeraad ah si aad u dareento qanci? Dhib malahan waan ku helay! Ka waran maqaalkan soo socda, Waxa cinwaan looga dhigay, Doorka Daawaynta ee Cunnada Ketogenic ee Xanuunada Neerfaha.
Dib-u-eeggani wuxuu xooga saarayaa in cuntada ketogenic laga yaabo inay bixiso faa'iidooyin daweyn oo loogu talagalay bukaannada qaba arrimaha neerfaha, gaar ahaan iyada oo wax laga qabanayo neuroinflammation, oo ah arrin muhiim ah oo wax ku biirinaysa xaaladahan. Marka la baadho suugaanta sayniska, way caddahay in cuntada ketogenic saamayn ku yeelan karto ma aha oo kaliya koorsada xanuunka neerfaha laakiin sidoo kale waxtarka daaweyntooda. Qorayaashu waxay soo jeedinayaan in cuntada ketogenic ay tahay inay qayb ka noqoto daaweynta kuwa qaba arrimaha neerfaha.
Waqtigan xaadirka ah, waxay u muuqataa in KD ay ku siin karto faa'iidooyin daweyn bukaannada qaba dhibaatooyinka neerfaha iyadoo si wax ku ool ah u xakameynaya dheelitirka u dhexeeya hababka pro- iyo antioxidant iyo pro-excitatory and inhibitory neurotransmitters, iyo beddelidda caabuqa ama beddelaadda halabuurka microbiome ee mindhicirka.
Pietrzak, D., Kasperek, K., Rękawek, P., & Piątkowska-Chmiel, I. (2022). Doorka daaweynta ee cuntada ketogenic ee xanuunada neerfaha. Nafaqooyinka, 14(9), 1952. https://doi.org/10.3390/nu14091952
Ugu Dambeyn
Haddaba muxuu lataliyaha caafimaadka dhimirka u xiiseynayaa qoraalka caafimaadka maskaxda ee ku saabsan Cudurka Maaddada Cad iyo hubinta inaad ogtahay in cuntada ketogenic ay tahay daaweyn suurtagal ah? Sababtoo ah qaarkiin (ama kuwa aad jeceshahay) waxay yeelan doonaan niyadda, xusuusta, iyo calaamadaha dheelitirka ee la socda cudurro kala duwan oo White Matter ah. Oo marka skaanka lagu arko, waxaa la siin doonaa daweyn aan waxtar lahayn.
Daawaynta hadda jirta, sida aad qiyaasi karto, waa kuwo aan dhiirigelin lahayn—daawaynta jidhka, daawaynta hypertension iyo sonkorowga, iyo daawashada kolestaroolkaaga. Waxaad ka akhriyi kartaa fursadahan daawaynta caadiga ah halkan:
https://my.clevelandclinic.org/health/diseases/23018-white-matter-disease
Waxaa laga yaabaa in halkii aad dadka u sheegi lahayd in aysan ka welwelin waxyeelada cadaanka ah ee lagu soo qaaday sawirada "gabowga" iyo in aan laga welwelin, waxaan yeelan karnaa dhakhaatiirta neerfayaasha waxay bixiyaan cunto ketogenic ah.
Waxaa laga yaabaa in dhakhtarka neerfaha uu qof u sharxi karo in cuntada ketogenic, hal mar, ay joojin karto, gaabin karto, ama xitaa bedeli karto cudurkooda cadcad iyagoo si toos ah wax uga qabanaya dheef-shiid kiimikaadka iyo habka difaaca jirka.
Waa maxay sababta firfircoonida microglial iyo shaqada aan loogu beegsanayn cunto ketogenic ah oo ah istaraatiijiyad daweyn oo suurtagal ah oo lagu daweynayo cudurrada cadaanka ah?
Sida aad arki karto, caddaynta sayniska ayaa horeba u jirta.
Haddii aad u baahan tahay caawimo barashada sida loo hirgeliyo cunto ketogenic ah oo loogu talagalay cudurka maadadda cad ama arrimaha kale ee neerfaha, waxaad waydiin kartaa barnaamijkayga internetka ee hoose:
tixraacyada
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Guan, Y.-F., Huang, G.-B., Xu, M.-D., Gao, F., Lin, S., Huang, J., Wang, J., Li, Y.-Q ., Wu, C.-H., Yao, S., Wang, Y., Zhang, Y.-L., Teoh, J., Xuan, A., & Sun, X.-D. (2020). Saamaynta ka-hortagga niyad-jabka ee cuntada ketogenic waxaa lagu dhexdhexaadiyaa iyada oo loo marayo dib-u-soo-celinta firfircoonida microglial iyo dareenka neerfaha ee habenula lateral. Maskaxda, Dabeecadda, iyo Xasaanadda, 88, 748-762. https://doi.org/10.1016/j.bbi.2020.05.032
MASKAXDAADA WAAN KU DARYEELAYAA DR. SULLIVAN (Maareeye). (2022, Diseembar 14). Cudurka Maaddada Cad. https://www.youtube.com/watch?v=O1ahjr-8qjI
Morris, G., Puri, BK, Maes, M., Saytuun, L., Berk, M., & Carvalho, AF (2020). Doorka microglia ee ciladaha neuroprogressive: Farsamooyinka iyo saameynta daaweynta neerfaha ee suurtagalka ah ee ketosis-ka-soo-baxa. Horumar xagga cilmu-nafsiga iyo cilmu-nafsiga, 99, 109858. https://doi.org/10.1016/j.pnpbp.2020.109858
Pietrzak, D., Kasperek, K., Rękawek, P., & Piątkowska-Chmiel, I. (2022). Doorka Daawaynta ee Cuntada Ketogenic ee Xanuunada Neerfaha. Nafaqooyinka, 14(9), Qodobka 9aad. https://doi.org/10.3390/nu14091952
Sweeney, MD, Montagne, A., Sagare, AP, Nation, DA, Schneider, LS, Chui, HC, Harrington, MG, Pa, J., Law, M., Wang, DJJ, Jacobs, RE, Doubal, FN , Ramirez, J., Black, SE, Nedergaard, M., Benveniste, H., Dichgans, M., Iadecola, C., Jacayl, S., … Zlokovic, BV (2019). Dhiig-xumada xididdada dhiigga - lammaanaha aan la tixgalin ee cudurka Alzheimers. Cudurka Alzheimers & Dementia, 15(1), 158-167. https://doi.org/10.1016/j.jalz.2018.07.222
Wardlaw, JM, Smith, C., & Dichgans, M. (2019). Cudurrada maraakiibta yaryar: Farsamooyinka iyo saamaynta bukaan-socodka. Nanjaha Lancet, 18(7), 684-696. https://doi.org/10.1016/S1474-4422(19)30079-1
Yang, X., & Cheng, B. (2010). Dhaqdhaqaaqa Neuroprotective iyo Ka-hortagga-bararka ee Cuntada Ketogenic ee Neurotoxicity-ku-abuuray MPTP. Journal of Molecular Neuroscience, 42(2), 145-153. https://doi.org/10.1007/s12031-010-9336-y