Cuntooyinka Ketogenic ee ADHD

Cuntooyinka Ketogenic ee ADHD

Keto Ma caawin karaa ADHD?

Cuntooyinka ketogenic waxay caawin karaan ADHD iyadoo la daaweynayo dhowr meelood oo ka mid ah cudurrada hoose ee loo aqoonsaday inay sababaan calaamadaha. Meelahan waxaa ka mid ah gulukooska hypometabolism, dheellitir la'aanta neurotransmitter, factor neurotrophic ee maskaxda oo hooseeya, caabuq, iyo walbahaarka oksida. Cunto ketogenic si fiican loo qaabeeyey ayaa sidoo kale wanaajin karta heerka nafaqada waxayna daweyn kartaa isku filnaansho la'aanta dadka ADHD.

Shaxda content

Hordhac

Feejignaanta Deficit Disorder (ADD) iyo Feejignaanta Deficit Hyperactivity Disorder (ADHD) ayaa loo arkaa inay ugu horrayn saameyn ku leeyihiin hidde-sideyaasha 80% ee kiisaska. Si kastaba ha ahaatee, sida dhammaan hiddo-wadaha, bay'ada soo celisa hiddo-wadahaas iyo daminta waa arrin awood leh oo loo yaqaan 'epigenetics'. Iyo qaab nololeedka, cuntada, jimicsiga, soo-gaadhista qorraxda, bay'adaha walaaca leh, sunta ayaa dhamaantood ah qodobbada epigenetic ee qasabka ah. Taas oo la macno ah in ay hiddo-sideyaasha qaar ka dhigi karaan in ay is-muujiyaan in badan kuwa kalena ay wax yar isu muujiyaan. Markaa wax la mid ah cuntada ketogenic, taas oo ah cunno awood leh oo cunno iyo qaab-nololeedka epigenetic factor, ayaa laga yaabaa inay kaa caawiso yaraynta ama yaraynta qaar ka mid ah calaamadaha ADHD.

Laakiin aan caddeeyo. Ma jiraan RCT-yada muujinaya in cuntada ketogenic ay waxtar u leedahay ADHD iyo ADD. Laakiin waxaa laga yaabaa inay dhowaan yimaadaan. Sida caddaynta sheeko-xariiradu sii korodho, danaha iyo maalgelinta RCT-yada ayaa aad ugu dhow. In kasta oo aynaan waligeen arki doonin iyaga oo loo sameeyo si adag sidii aan u samayn lahayn dawooyinka leh faa'iidada sare leh. Weli, haddii aad ka raadiso Reddit ADHD, ADD, iyo Keto, waxaad heleysaa dad badan oo la wadaagaya sheekadooda in cuntada ketogenic ay caawisay. Waad akhrin kartaa qaarkood halkan. Iyo sida qaar badan ay hore u waydiiyeen, waxaad u badan tahay inaad timid boggan adigoo weydiinaya su'aasha "Keto ma caawin kartaa ADHD?"

Boostada blog-ka ayaa sahamin doonta qaar ka mid ah hababka ay cuntada ketogenic ka caawin karto daaweynta qaar ka mid ah calaamadaha ADHD iyo ADD. Qoraaladii hore, waxaan sahaminay sida cuntada ketogenic u daaweyso afarta qaybood ee hoose ee cudurada, guud ahaan. Waxaad akhrin kartaa qoraalladan yaryar laakiin macluumaadka xambaarsan halkan, halkan, Iyo halkan. Maqaalkan, waxaan ku baari doonaa isla afartan meelood ee pathology-ga ee lagu arko ADHD iyo ADD waxaanan sahamin doonaa in cuntada ketogenic ay hagaajin karto calaamadaha ka iman kara meelahan cilladaysan:

  • Glucose Hypometabolism
  • Isku dheelitir la'aanta Neerfaha
  • caabuq
  • murqo-

Maqaalkan blog-ka ah, waxaan ku balaadhin doonaa meelahan daawaynta ee suurtogalka ah si aan ugu daro macluumaad guud oo ku saabsan factor neurotrophic-maskaxeed (BDNF) iyo doorka habka difaaca jirka ee ADHD/ADD. Labaduba waa arrimo khuseeya si aad u sahamiso markaad isku daydo inaad ka jawaabto bal in cuntada keto ay ka caawin karto ADHD iyo ADD.

Ma geli doono calaamadaha ama shuruudaha ogaanshaha ADHD si faahfaahsan blogkan. Looma jeedo in sidaas lagu wargeliyo, waxaana jira maqaallo badan oo internetka ah oo bixiya macluumaadkan. Haddii aad heshay blog-gan, waa sababta oo ah waxaad taqaanaa waxa ADHD iyo ADD yihiin, waxaana laga yaabaa inaad raadinayso siyaabo aad ku daaweyso naftaada ama qof aad jeceshahay.

Waxaa laga yaabaa inaad la yaabto inaad daweyn karto ADHD la'aanteed dawooyinka kicinta. Ama waxaa laga yaabaa inaad sahamiso in qaadashada cuntada ketogenic iyo haddii kale ay kuu oggolaan karto inaad u baahato daawo kiciya oo yar. Daawooyin yar ayaa faa'iido yeelan kara, gaar ahaan maadaama daawooyinka dhimirka ay yareeyaan nafaqooyinka.

Daawooyinka dhimirka, sida kuwa loo isticmaalo daawaynta ADHD iyo ADD, waxay baabi'iyaan nafaqooyinka soo socda:

  • magnesium
  • Iron
  • folate
  • Omega 3s
  • B1, B2, B3, B6 iyo B12
  • Zinc
  • CoQ10

Nafaqo-darrada yar yar ee isticmaalka daawada waxaa u sii dheer xakamaynta rabitaanka cuntada ee laga helay ADHD iyo daawooyinka ADD. Xakamaynta rabitaanka cuntada ee ay keento isticmaalka daawadu waxay keeni kartaa adiga ama qofka aad jeceshahay inaadan cunin wax ku filan si aad u buuxiso xaalufkan. Waxaa laga yaabaa inaad rabto inaad awood u yeelatid inaad qaadato daawo kicinaysa sababtan oo keliya. Liistada sare ee nafaqo-xumada ayaa ku habboon oo si toos ah u saameeya sida ugu wanaagsan ee maskaxdaadu u shaqeyn karto. Haddii maskaxdaadu ay dabcin karto awood waxqabad si ay ugala hadasho neerfayaasha, samaynta neurotransmitters, yarayso bararka, iyo dayactirka lafteedu waxay dhammaantood ku xiran yihiin qadar ku filan oo nafaqooyinka kor ku qoran.

Yaab, waan ogahay.

Waxaa laga yaabaa inaad u akhrinayso blog-gan sababtoo ah waxaad leedahay ADHD ama ADD kaliya, ama waxaa laga yaabaa inaad akhrinayso blog-gan sababtoo ah waxaad qabtaa ADHD iyo cudur kale oo isku dhafan oo aad ka raadinayso gargaar. Dad badan oo qaangaar ah oo qaba ADHD ayaa la ildaran xaalado isku dhafan, oo ay ka mid yihiin:

  • khalkhal shakhsiyeed ka soo horjeeda bulshada (14-24%)
    • Fiiro gaar ah: Carruurta waxa lagu ogaadaa inta badan waa xanuunka Mucaarad-Defiant. Haddii ay ku sii socoto da'da 18 ee dhaaftay, baaristu waxay isu beddeshaa PD-da bulshada lidka ku ah
  • khalkhalka shakhsi ahaaneed ee xuduudaha (14%)
  • xanuunada saameeya niyad-jabka (20%)
  • laba-cirifoodka (20%)
  • walaac (ilaa 50%)
  • cuqdad bulsho (32%)
  • weerarada argagaxa (15%)
  • xanuunka waswaaska ah (20%)
  • si xun u isticmaalka mukhaadaraadka (20-30%)

Iyadoo aan loo eegin sababta aad u akhrinayso blog-gan, waxaan rajeynayaa in dhamaadka, aad si fiican u fahmi doonto sida cuntada ketogenic ay u noqon karto daaweyn aasaasiga ah ama dhamaystirka calaamadaha ADHD ama ADD.

ADHD iyo hypometabolism

Hypometabolism waa erey aan isticmaalno si aan u qeexno meelaha maskaxda ee aan si fiican u isticmaalin tamarta (hypo=low; metabolism=use of energy). Dadka qaba ADHD waxay leeyihiin meelo maskaxda ah oo aan firfircoonayn oo ku filan waxaana loo aqoonsaday inay leeyihiin hypometabolism maskaxda ee dhismayaasha qaarkood. Hypometabolism ee maskaxda ADHD waxaa lagu arkaa kiliyaha hore ee hore (inta badan midig), nucleus caudate, iyo cingulate hore. Waxaan sidoo kale arki karnaa saameyn guud oo ku saabsan qaadashada gulukooska ee maskaxda ADHD ee dadka waaweyn ee leh calaamadaha firfircoonida.

Dheef-shiid kiimikaad ee gulukooska maskaxda ee caalamiga ah ayaa 8.1% ka hooseeyey dadka waaweyn ee qaba firfircoonida badan marka loo eego kontaroolada caadiga ah. 

Zametkin, AJ, Nordahl, TE, Gross, M., King, AC, Semple, WE, Rumsey, J., … & Cohen, RM (1990). Dheef-shiid kiimikaad ee gulukooska maskaxda ee dadka qaangaarka ah ee leh firfircoonida caruurnimada bilawga. DOI: http://doi.org/10.15844/pedneurbriefs-4-11-4

Daraasadaha xayawaanka, mid ka mid ah hababka methylphenidate (oo lagu iibiyo sida Ritalin iyo magacyada kale ee daroogada) waa in daawadu ay kordhiso qaadashada gulukooska ee maskaxda. Dhibaatooyinka gulukoosta hypometabolism ee gobollada maskaxda ee aan soo sheegnay ayaa ku jira carruurta, dhalinyarada, iyo dadka waaweyn. Dadka qaangaarka ah ee laga helay ADHD markay caruur ahaayeen waxay maskaxda ku hayaan gobollo gulukoos hypometabolism ah markay qaangaarayaan.

Waxaa jira xitaa caddayn ah in kala duwanaanshaha hidde-sidaha ay yihiin waxa keena gulukooska hypometabolism inuu dhaco, gaar ahaan shaqeynta qaar ka mid ah soo-dhoweeyayaasha muhiimka ah sida GLUT3. Marka GLUT3 ay si sax ah u shaqeyso, waxay dhexdhexaadisaa qaadashada gulukooska ee neerfaha waxaana inta badan laga helaa axon iyo dendrites. Laakiin shakhsiyaadka qaba ADHD, waxaan aragnaa in polymorphism-yada hidde-sidaha ay saameyn ku yeeshaan awoodda GLUT3 inay si sax ah u shaqeyso iyo in tani ay noqon karto waxa keena dhibaatooyinka hore ee neurocognitive ee loo maleynayo inay gacan ka geystaan ​​khatarta ADHD.

Sida cuntooyinka ketogenic u caawiyaan hypometabolism maskaxda ee ADHD

Hmmm. Miyayna fiicnaan lahayn haddii uu jiro shidaal kale oo loogu talagalay maskaxda ADHD/ADD? Mid aan ku tiirsanayn gulukoosta ama ay tahay inuu la tacaalo gaadiidleyda GLUT3 ee khaldan? Nasiib wanaag waxaa jira! Waxay dhacdaa inay noqoto cuntada ketogenic.

Cuntooyinka ketogenic waxay siiya shidaal beddelka ah maskaxda loo yaqaan ketones. Ketones-yadani waxay si toos ah u galaan maskaxda iyagoo ah il shidaal. Gaadiid qurxoon oo glut ah looma baahna. Ketones waxay isticmaalaan gaadiidleyda monocarboxylate (MCTs), kuwaas oo aad ka helayso wax badan oo dufan caafimaad leh oo ku saabsan cuntada ketogenic.

Waxyaabaha waalanna waa, ketones kaliya kama caawiyaan mitochondria-gaaga hadda jira si ka sii fiican, laakiin waxay ku dhiirigeliyaan unugyada maskaxdaada inay sameeyaan wax badan. Waxaana jira wax badan oo aad ku samayn karto kor u qaadistaas weyn ee tamarta maskaxda. Gaar ahaan haddii ay ku dhacdo lafaha hore.

Maxay sameeyaan mitochondria?

Sida haddii bixinta shidaalka beddelka maskaxda ee maskaxda hypometabolic kuma filna, ketones sidoo kale waxay kordhiyaan dheef-shiid kiimikaadka tamarta iyagoo kor u qaadaya mitochondria unugyada neerfaha. Mitochondria waa baytariyada unugyadaada. Aan caddeeyo. Mitochondria yari waa sida reactors koronto. Erayga "batteriyada" kaliya ma cadaalad sameeyo.

Laakin sug Wax kale ayaa jira.

Ketones waxay soo saaraan tamar ka badan gulukoosta. Si sax ah, qiyaastii 48 ATP vs. 36 ATP ee aad ka hesho gulukoosta.

Waxaa jira qoraal yar oo blog ah oo ku saabsan ketosis, mitochondria, iyo makaanikada sida ketones u sameeyo ATP halkan (Mahadsanid, Siimland).

Cilmi baaristu gabi ahaanba waa jahawareertay oo aan iswaafaqsanayn inta ay le'eg tahay inta uu le'eg yahay ATP unuggu, iska daa intee le'eg ayay tahay heerka tamarta unugu u baahan yahay si uu u kobco iyada oo ka soo horjeeda shaqada ugu yar ee bannaan. Cilmi-baaristu xitaa aad ayey uga yar tahay inta ay le'eg tahay ATP-da neuron-ka caadiga ah, astrocyte, ama unugga glial ayaa si fiican u isticmaali kara. Kaliya ogow in maskaxdaadu isticmaasho 70% dhammaan ATP-yada aad ku abuurto jirkaaga oo dhan. Waxaadna bilaabi doontaa inaad fahamto muhiimada helitaanka ketones sida isha tamarta ee maskaxda ADHD.

"Laakiin sug hal daqiiqo!" Waxaa laga yaabaa inaad i leedahay markaad akhriyayso blog-gan. Maxay tani ka qabtaa calaamadahayga? ADHD/ADD waxay leedahay shuruudo lagu ogaanayo. Qayb ka mid ah shuruudahaasna waxay hoos yimaadaan waxa loo yaqaan hawl-gabka fulinta.

Cilad la'aanta fulinta, oo sidoo kale loo yaqaan 'executive function deficit' ama khalkhalka, waa marka maskaxdu ay ku adag tahay waqti adag xirfadaha dareenka, xusuusta, fekerka dabacsan, iyo maamulka / maaraynta wakhtiga.

https://www.verywellmind.com/what-is-executive-dysfunction-in-adhd-5213034

Waxqabad la'aanta fulinta waxay ka timaadaa lafaha hore ee jaban. Lafaha hore ee jaban waxay ka iman karaan dhaawac madaxa ah, istaroog, ama iyagoo aan helin shidaal ku filan oo uu ku ordo.

Taasina, saaxiibkay akhriska blog-ka, waa sida cuntada ketogenic u daweyn karto hypometabolism-ka hoose ee lobe-ka hoose ee qayb ka ah habka cudurka ee hoosta ka xariiqaya calaamadaha ADHD / ADD.

ADHD iyo Isku dheelitir la'aanta Neurotransmitter

Waxaa jira dhowr isku dheelitir la'aanta neurotransmitter ee ADHD iyo ADD. Kuwaas waxaa ka mid ah serotonin, dopamine, noradrenaline, glutamate, iyo GABA. Intaa waxaa dheer, waxaa jira hoos u dhac lagu arkay walax muhiim ah oo loo yaqaan 'brain-derived neurotrophic factor' (BDNF). Iyadoo aan farsamo ahaan ahayn neurotransmitter, waxay saameyn ku leedahay nidaamka glutamate/GABA sidaas darteedna waa lagu dari doonaa.

Serotonin

Kala duwanaanshaha muujinta hidda-wadaha ee laga helo kuwa qaba ADHD ayaa beddela shaqada soo-qabayaasha serotonin. Tani waxay ka dhigan tahay in sida unugyada dareemayaasha ay u helaan oo ay isticmaalaan serotonin neurotransmitter waa la bedelay. Farqiga u dhexeeya kuwan soo dhoweeyayaasha iyo sida ay u saamayso isku xidhka u dhexeeya qaab-dhismeedka maskaxda ayaa loo malaynayaa inay saameeyaan qaar ka mid ah waxbarashada iyo daciifnimada xusuusta ee aan ku aragno dadka ADHD. Heerarka la dhimay ee serotonin ayaa loo maleynayaa inay la xiriiraan calaamadaha niyad-jabka ee lagu arkay qaar ka mid ah astaamaha cudurka.  

dopamine

Cilad kale oo weyn oo neurotransmitter ah oo lagu arko ADHD waa dopamine. Aragtiyadii hore waxay soo jeediyeen in heerarka hooseeya ee dopamine, oo ay weheliyaan qaar ka mid ah neurotransmitters, ay yihiin sababta asaasiga ah ee ADHD. Aragtidani waxay tan iyo markaas u dhaqaaqday fikradda ah in dhibaatadu aysan ahayn sababtoo ah ma jiraan dopamine ku filan laakiin sababtoo ah waxaa jira heerar sare oo gaadiidley ah oo loogu talagalay dopamine. Qaadayaasha Dopamine waxay u oggolaanayaan dopamine inay galaan unugyada dareemayaasha iyada oo loo marayo xuubka presynaptic ee si fiican u shaqeynaya.

U fiirso waxa aan hadda qoray. Si loo isticmaalo dopamine, waa inaad leedahay xuubka presynaptic oo si fiican u shaqaynaya. Tani waxay khusayn doontaa hadhow marka aan ka hadlayno daaweynta.

Haysashada gaadiid badan oo dopamine ah oo shaqada ku jira waxay la macno tahay in dopamine-ku aanu ku hayn waqti dheer oo ku filan dillaaca presynaptic ee wakhtiga saxda ah. Waxa lagu faaruqiyaa dhammaan reseptors-yadaas. Ma samayn karto shaygeeda!

Sababtoo ah dopamine ma qabsan karto shaqadeeda, qofka ADHD qaba way ku adag tahay inuu raadsado raaxo oo uu dareemo in lagu abaalmariyo waxyaabo lagu farxo maalintii oo dhan. Waxay ku xiran yihiin si ay u raadiyaan dopamine dheeraad ah. Waa sababta dadka ADHD ay u yeelan karaan dhibaatooyin xagga isticmaalka casriga ah, ciyaaraha kombayutarka, iyo xitaa cuntooyinka warshadaysan ee balwadda leh. Dhammaan waxyaalaha si taxadar leh ayaa loogu talagalay in lagu bixiyo jawaab celin sare oo dopamine ah maskaxda. Waxaa jira dareen gaar ah oo ah inaadan ku raaxaysanayn la'aanteed dhaqdhaqaaqyadan dheeraadka ah ee kicinta iyo cuntooyinka. Dhammaan tani waxay keenaysaa in la dareemo degenaansho la'aan, u dhaqmo si degdeg ah, iyo dhibaatooyin xagga dareenka ah.

Waxaa ka mid ah qodobbada neuro-kiimikada, waxaa jira nidaam la'aan si fiican loo yaqaan ee soo saarista neurotransmitters; gaar ahaan dopamine iyo nor-adrenaline.

Fayed, NM, Morales, H., Torres, C., Coca, AF, & Ríos, LF Á. (2021). Maskaxda Resonance Resonance Imaging in Feejignaan-Deficit/Hyperactivity Disorder (ADHD). https://link.springer.com/chapter/10.1007/978-3-030-61721-9_44

Dhowr nooc oo kala duwan oo hidde ah ayaa gacan ka geysta arrimaha shaqada dopamine ee lagu arko kuwa leh ADHD iyo ADD. Waxaa loo maleynayaa in kala duwanaanshaha hidde-sideyaasha heerar kala duwan ay gacan ka geystaan ​​dhammaan bandhigyada badan ee xanuunka aan ku aragno shakhsiyaadka. Tusaale ahaan, COMT polymorphisms ee saameeya nidaamka dopaminergic waxay si aad ah ugu xiran yihiin calaamadaha ADHD iyo naafanimada bulshada.

Norepinephrine

Norepinephrine waa neuromodulator kaas oo leh door muhiim ah, oo ay weheliso dopamine, taasoo u oggolaanaysa kiliyaha hore ee hore inuu shaqeeyo. Xusuusnow, waxaan ka wada hadalnay kiliyaha hore iyo waxa uu horay u qabto bartan blog-ka. Kortex hore oo aan shaqaynayn ayaa u horseedi doonta hoos u dhac ku yimaada shaqada fulinta kuwaas oo inta badan ah heer-hoosaad calaamadaha lagu arko ogaanshaha ADHD/ADD.

In kasta oo inta badan cilmi-baarista ay jecel yihiin in ay diiradda saaraan dopamine, norepinephrine saamaynta ay ku leedahay kiliyaha prefrontal waa sidaas oo kale oo aad u la yaab leh fahamka calaamadaha ADHD. Marka norepinephrine ay si fiican u shaqeyso, waxay ka caawisaa xusuusta shaqada iyo dareenka. Dadka qaba ADHD/ADD waxay ka warbixiyaan arrimo halis ah oo leh xusuusta shaqada iyo dareenka.

Waxaan ognahay in norepinephrine ay ku lug leedahay, qayb ahaan, sababtoo ah daawooyinka noradrenergic ee xulashada ah (tusaale, clonidine, guanfacine) ayaa kaa caawin kara daaweynta ADHD.

Mar kale, waxaanu la tacaalaynaa arrin gaadiidlay ah. Ma aha qasab in ay jiraan wax aad u badan ama aad u yar oo norepinephrine ah, laakiin waxaan aragnaa kala duwanaansho hidde-side ah oo saameeya sida waxa horeba u jiray loo wareejinayo loona isticmaalo. Mar labaad, waxaan aragnaa in kala duwanaanshaha hidde-sidaha qaarkood ee lagu arkay ADHD iyo ADD ay ku lug leeyihiin sida gaadiidka norepinephrine (NET) u shaqeeyo.

Glutamate iyo GABA

Waxaan si wadajir ah uga wada hadalnaa labadan neurotransmitters sababtoo ah waxay ka mid yihiin nidaamka xarrago leh ee wada shaqeeya. ADHD, waxaan ku aragnaa dheelitir la'aanta nidaamkan neurotransmitter. Heerarka Glutamate ee kiliyaha hore, tusaale ahaan, waxay si toos ah u saameyn doontaa heerarka dopamine iyo ku xigeenka.

Xanuunada korriinka neerfaha qaarkood, sida ADHD, waxaan aragnaa isku dheelitir la'aanta u dhaxaysa glutamate neurotransmitter kacsan iyo GABA xannibaado ah. Daawooyinka loo yaqaan 'Dopamine'DRD4) cillad la'aanta lagu arko ADHD waxay abuurtaa jawi ay maskaxda ku jirto glutamate badan. Ma rabno tan oo glutamate ah oo kaliya oo ka laalaada maskaxda, oo aan lagu dheellitirin GABA. Sababtoo ah muddada dheer, tani waxay dhaawac u geysataa unugyada maskaxda iyo dhismayaasha maskaxda.

Glutamate waa calaamad muhiim ah oo neurotoxic ah. Xad-dhaafka glutamate wuxuu soo saari karaa dhimashada neerfaha iyada oo loo marayo hababka excitotoxic. Waxaa sidoo kale loo maleynayaa in glutamate ee wareegyada hore ay tahay xakameyn muhiim ah oo dopamine ah, iyada oo loo marayo habka jawaab-celinta qiyaasta dopamine waxay saameyn ku yeelan kartaa xoojinta glutamate.

Fayed, NM, Morales, H., Torres, C., Coca, AF, & Ríos, LF Á. (2021). Maskaxda Resonance Resonance Imaging in Feejignaan-Deficit/Hyperactivity Disorder (ADHD). Gudaha Cusboonaysiinta Cilmi-nafsiga iyo Cilmi-nafsiga ( bogga 623-633). Springer, Cham

Carruurta qabta ADHD waxay muujinayaan kontoroolka xannibaadda liidata waxayna si weyn hoos ugu dhacday GABA gudaha striatum, taas oo ah qaab-dhismeedka maskaxda ee ku lug leh labadaba go'aaminta ficillada la qabanayo iyo barashada ficilladaas kuwa mudan in lagu celiyo. Heerarka liidata ama ka faa'iidaysiga GABA ayaa loo malaynayaa inay gacan ka geystaan ​​calaamadaha ka-hortagga dabeecadda ee lagu arko ADHD.

Wax ku biirinta noocaan gaarka ah ee dheellitir la'aanta neurotransmitter maaha mid muhiim ah. Iyo saamaynta labadan neurotransmitters ee dheelitirka ka baxsan ayaa loo maleynayaa inay si toos ah uga qaybqaataan etiology ee ADHD iyo saamaynta neerfaha ee sii socota qaan-gaarnimada.

Cunsurka neurotrophic ee maskaxda ka soo jeeda (BDNF)

BDNF waxaa la ogaaday in lagu xakameeyey ADHD. Qaar ka mid ah kuwan ayaa laga yaabaa inay sabab u tahay kala duwanaanshaha hidde-sideyaasha laga helay dadkan. Iyo dadka qaba ADHD/ADD waxay dareemayaan sahaydan ku filan. Sababtoo ah hippocampus kaaga, qaab dhismeedka maskaxda ee caawiya habsocodka xusuusta wakhtiga gaaban, aad buu u firfircoon yahay, waxayna u baahan tahay BDNF badan si ay si sax ah u shaqeyso. Hoos-u-dhigga walaxdan ayaa laga yaabaa inay tahay sababta aan u aragno arrimaha leh xusuusta muddada-gaaban iyo shaqada ee dadka qaba ADHD. Waxaad sidoo kale u baahan tahay BDNF kugu filan si aad wax u barato guud ahaan. Waxaad u baahan tahay si aad u muujiso glutamatergic iyo GABAergic (ergic = samaynta) synapses, waxayna sidoo kale door ka ciyaartaa serotonin iyo dopamine isu gudbinta unugyada. Guntii iyo gabagabadii dadka qaba ADHD ma haystaan ​​ku filan alaabtan wanaagsan. Oo waxaan u baahanahay inaan helno qaab aan ku kordhin karno.

Sida cuntooyinka ketogenic u caawiyaan isu dheelitir la'aanta neurotransmitter ee lagu arkay ADHD

Haddaba sidee bay cuntada ketogenic u hagaajin kartaa calaamadaha ADHD? Ka dib oo dhan, waxay u egtahay in ADHD ay inta badan tahay hidaha. Sidee cuntada ketogenic wax uga beddeli kartaa muujinta hiddo-wadaha kuwaas oo go'aaminaya sida neurotransmitters-keena u shaqeeyaan (ama aysan u shaqayn)? Sidee daawaynta cuntada u bedeli kartaa wax weyn oo sidaas oo kale ah?

Dopamine, Noradrenaline, iyo Serotonin

Waxaa laga yaabaa inaan hore u soo sheegay tan, laakiin waxaa jira saddex nooc oo ketones ah. Mid ka mid ah noocyadaas waxaa loo yaqaan beta-hydroxybutyrate (βHB). βHB waxay soo saartaa wax badan oo ah ensaymes udub dhexaad u ah dheef-shiid kiimikaadka (wax soo saarka tamarta) oo loo yaqaan nicotinamide adenine dinucleotide (NADH). Waxay tan ku samaynaysaa waddo adag oo aad ka eegi karto halkan (fiiri sawirka 3) haddii aad xiisaynayso heerkaas.

Ujeeddooyinkeena halkan, waxa kaliya oo muhiim ah in la ogaado in tani ay kordhinayso isku-dhafka iyo/ama shaqada neurotransmitters dopamine, noradrenaline, serotonin, iyo melatonin.

Haddii aad xasuusato akhrintaada sare, kala duwanaanshaha hidde-qabayaasha neurotransmitter-ka iyo muujinta gaadiidka ee serotonin, dopamine, iyo norepinephrine waa arrimo lagu arko maskaxda ADHD. Ka dhigista mid kasta oo badan waxay noqon kartaa mid faa'iido leh.

  • Kordhinta serotonin waxay wanaajin kartaa niyad-jabka, barashada iyo xusuusta daciifka ah
  • Kordhinta dopamine waxay yareyn kartaa xasilloonida iyo hagaajinta dareenka
  • Kordhinta norepinephrine waxay hagaajin kartaa xusuusta shaqada iyo dareenka

Waxaa jiri lahaa wanaag badan oo neurotransmitter ah oo lagu wareego, waxayna la macno tahay inay u badan tahay inay jiraan wax badan oo ku sii jiri doona synapses halkaas oo ay ka shaqeyn karaan sixirkooda. Iyo kor u qaadistan neurotransmitters ee muhiimka ah waxaa lagu sameeyaa hab dheellitiran oo leh cunto ketogenic ah.

Si ka duwan daawooyinka ay neurotransmitters-ka qaarkood la kordhiyo ama laga dhigo inay sii joogaan inta suurtogalka ah ee synapses, ma jiri doonto saameynaha daawada. Dhammaanteen si fiican ayaan ula soconaa, tusaale ahaan, dhibaatooyinka ay dadku la kulmaan marka ay qaadanayaan SSRIs si ay u kordhiyaan wakhtiga ay serotonin ku sii jirto synapses si loo isticmaalo. Waxaan ognahay in gabapentin, loogu talagalay in lagu kordhiyo heerarka GABA ee maskaxdu ay abuuri karto saameynaha hurdada, tusaale ahaan. Noocan oo kale kuma dhaco cuntada ketogenic.

Laakiin waxa ku saabsan glutamate iyo GABA?

Sida kor looga hadlay, maskaxda ADHD waxay la halgameysaa glutamate aad u badan iyo GABA aad u yar. Cuntooyinka ketogenic waxay kordhin karaan firfircoonida glutamic acid decarboxylase, taas oo dhiirigelisa isku-darka GABA iyo sidoo kale beddela hawlaha enzyme taas oo GABA ku ilaalinaysa wakhti dheer oo ah synapses. Marka maskaxda ADHD, tani waxay ka dhigan tahay helitaan dheeri ah oo ku saabsan neurotransmitter-ka-hortagga ah ee loo baahan yahay si looga caawiyo isu-dheellitirka heerarka sare ee glutamate.

Daraasadaha xayawaanka, mid ka mid ah qaababka ketone ee loo yaqaan acetoacetate ayaa la ogaaday si loo yareeyo neurotransmission excitatory at synapses hippocampal, taas oo laga yaabo inay wanaajiso ama ugu yaraan ilaalinta shaqada xusuusta. Shakhsiyaadka ADHD iyo ADD waxay inta badan ka cawdaan dhibaatooyinka xusuusta muddada gaaban iyo waxbarashada. Isku-dheellitirka shaqada neurotransmitter ee dhismayaasha xusuusta muhiimka ah sida hippocampus waxay caddayn kartaa inay caawiso dhimista calaamadaha.

shaqeynta Xubinta iyo dheellitirka neurotransmitter

Kaliya ma yeelan kartid wadahadal ku saabsan dheelitirka neurotransmitter adigoon ka hadlin shaqada xuubabka neerfaha. βHB waxay caawisaa xuubabka neerfayaasha inay dib u soo noqdaan, iyo in awoodda dib-u-soo-celinta ee la roonaaday ay faa'iidooyin badan u leedahay maskaxda ADHD/ADD.

Dib-u-soo-celinta xuubka neerfaha, oo ay xoojisay βHB waxay u oggolaanaysaa unuggu inuu ururiyo nafaqooyinka (badanaa ku yar maskaxda ADHD / ADD) si loo sameeyo neurotransmitters meesha ugu horeysa. Xusuusnow markii aan ka wada hadalnay arrimaha soo-dhoweeyaha neurotransmitter-ka iyo gaadiidka ee maskaxda ADHD/ADD?

Hagaag, dhismaha ensaymyada go'aaminaya inta neurotransmitter-ku helayo inuu ku dhex jiro dillaaca synaptik, iyo illaa intee ayaa wax lagu go'aamiyaa dib-u-celinta xuubka. Kala dillaaca synaptik 'awoodda ay ugu nugul yihiin neerfayaasha soo baxaya (sida dopamine, serotonin, iyo norepinephrine) waxay sidoo kale ku xiran tahay dib u habeynta shaqeynta caafimaadka leh.

Cunsurka neurotrophic ee maskaxda ka soo jeeda (BDNF)

Cuntooyinka ketogenic waxaa loo yaqaanaa inay hagaajiyaan wax soo saarka BDNF. Waxaa loo maleynayaa in tani ay noqon karto hab muhiim ah oo u oggolaanaya inay hagaajiyaan xanuunka neerfaha ee kala duwan, sida dhaawaca maskaxda (TBIs) iyo waallida. Ketones waxay hagaajiyaan BDNF doorkooda sida unugyadu calaamad muujinaysa, u rogaan hiddo-wadaha si ay u abuuraan wax badan oo ka mid ah walaxdan. Markaa soo saarista ketones, ee cuntada ketogenic, waxay ku abuuri doontaa BDNF badan maskaxda ADHD/ADD.

Hidde ma aha qaddar

ADHD waxaa loo arkaa inay aad u saameeyaan hiddo-wadaha. Mar kasta oo cudurka sidaas looga hadlo, dadku waxay heli karaan fikrad khaldan oo ku saabsan inay awoodaan inay "hagaajiyaan" ama beddelaan cudurrada hoose ee la xidhiidha xaalad.

Ma garanayno inta ay le'eg tahay dhibaatooyinka waxyaalahan ADHD waxay ka yimaaddaan xuubabka neerfaha ee daciifka ah sababtoo ah arrimo epigenetic ah (tusaale, hypometabolism sababtoo ah cuntada, yaraanta nafaqeeyayaalka yar yar, neuroinflammation chronic, stress oksaydhative).

In kasta oo dhibaatooyinka soo-dhoweeyayaasha iyo gaadiidleyda la sheegay inay ku dhacaan heer hidde-siyeedka kuwa maskaxda ADHD, waxaan rabaa inaan diiwaangaliyo sidii aan ula xiriiri lahaa inaan u maleynayo inay suurtagal tahay in beddelka deegaanka hiddo-wadahaas lagu muujiyey ay la macno tahay horumarinta astaamaha. . Sida muujinta hidde-sidaha ee serotonin, dopamine, iyo gaadiidleyda norepinephrine iyo daaweeyayaasha ayaa laga yaabaa inay ku habboon yihiin saamaynta epigenetic.

Iyo faragelinta epigenetic, sida cuntada ketogenic, ayaa aad u awood badan inay saameyn ku yeelato muujinta hiddaha. Ketones waa unugyayaal calaamad u ah, taasoo la micno ah inay awood u leeyihiin inay shidiyaan oo joojiyaan hiddo-wadaha. Sababtoo ah in laguu sheegay wax la dhaxlo macnaheedu maaha inaadan awoodin inaad wax ka beddesho sida hadalkaasi u dhaco.

ADHD iyo Neuroinflammation

Dadka qaba ADHD waxay leeyihiin heerar la taaban karo oo ah xanuunka neerfaha oo uga imaanaya jihooyin kala duwan. Caabuqa waxaa sababi kara sababo kala duwan. Cunto ay ku badan tahay fructose (cabitaannada macaan ee dukaanka ku habboon) waxay kordhin kartaa bararka. Wasakhowga ayaa kordhin kara bararka. Caqabad maskaxeed oo soo daatay oo sunta u ogolaata maskaxda waxay sababi kartaa caabuq. Cadaadiska ba'an, sida qaadashada imtixaan ama ku afuufida taayirka wadada xorta ah, waxay kordhin kartaa caabuq. Iyo habdhiska difaaca oo xumaada waxay kordhin kartaa caabuqa. U fiirso kan ugu dambeeya sababtoo ah bararka uu keeno hab-dhiska difaaca oo xumaada wuxuu u muuqdaa mid aad ugu habboon ADHD.

Haddaba maxay taasi ka dhigan tahay? Marka habka difaacayagu uu shaqeeyo, wax loo yaqaan cytokines ayaa markaa la soo saaraa. Kuwani waa unugyo yaryar oo calaamadeynaya oo u sheegaya habka difaaca waxa la sameeyo si loo ilaaliyo "nin xun" oo hadda loo sheegay inuu safka ku jiro. Laakin cytokines ma ahan kuwo khiyaano leh marka ay la dagaalamaan soo galootiga kala duwan. Waxyeelo badan ayay gaystaan. Bal qiyaas goob booliis oo fowdo ah oo eryanaya iyo dhammaan waxyeelada ka dhacda marka ay daba galaan ninka xun oo aad u xoog badan oo xawaare sare leh.

Taasi waa sida cytokines-ku u rogaan. Waxaa laga yaabaa inay qabtaan ama aysan qaban qofka xun, waxaana jira qas weyn oo kicinaya si loo nadiifiyo. Waxayna u baahan tahay xoog badan, qalab, iyo dhaqaale si loo sameeyo nadiifintaas. Maskaxda, taasi waxay ka dhigan tahay tamar la kharash gareeyay (shaqo), unugyo kale oo caafimaad qaba oo soo qaadi kara caajis (qalab), iyo nafaqeeyayaal yar yar oo aad uga badan inta aad ka heleyso cuntadaada.

Hadda qiyaas baabuur badan oo eryanaya mar walba, sida aan joogsi lahayn ( raag leh). Ugu dambeyntii, nadiifinta iyo dayactirka ayaa dib u dhici doona. Magaalada iyo waddadu waxay u ekaan lahaayeen qas kulul. Taasi waa maskaxdaada oo la tacaalaysa caabuqa neuroinflammation ee raaga.

Halkan waxaa ah maqaal weyn oo ku balaadhinaya isbarbardhiggan qaab kaa caawinaya inaad fahamto caabuqa neuroinflammation iyo walbahaarka oksaydhka, iyo sida ay isula xiriiraan midba midka kale!

Haddii Maskaxdaadu tahay Magaalo: Fahamka Cadaadiska Oxidative iyo Neuroinflammation

Habka ugu fiican ee aan u muujin karo sida bararka muhiimka ah ee ADHD waa in la bixiyo xigasho maqaal cilmi baaris ah oo aan u soo jiiday inaan qoro boostadan.

Iyadoo ay weli xaddidan tahay, caddayntan waxaa ka mid ah 1) fursadaha kor ku xusan ee ADHD oo leh xanuunka bararka iyo difaaca jirka, 2) daraasaadka bilowga ah ee tilmaamaya xiriirka ADHD iyo kororka cytokines serum, 3) caddayn horudhac ah oo laga helay daraasaadka hidaha ee muujinaya ururada u dhexeeya polymorphisms ee hiddo-wadaha la xidhiidha oo leh dariiqyada caabuqa iyo ADHD, 4) caddaynta soo ifbaxa in nolosha hore ee soo-gaadhista dhowr arrimood oo khatarta deegaanka ah ay kordhin karto khatarta ADHD iyada oo loo marayo habka bararka, iyo 5) caddaynta farsamada ee noocyada xayawaanka ee firfircoonida difaaca hooyada oo diiwaangelinaya natiijooyinka dabeecadaha iyo neerfaha ee la socda ADHD.

Dunn, GA, Nigg, JT, & Sullivan, EL (2019). Neuroinflammation sida arrin halis u ah cillad la'aanta feejignaanta. https://doi.org/10.1016/j.pbb.2019.05.005

Haddaba aan dib u eegno muhiimadda waxa aan hadda akhrinay. Dadka qaba ADHD waxay aad ugu dhow yihiin inay yeeshaan xanuunka caabuqa iyo isdifaaca jirka. Si kale haddii loo dhigo, wax ayaa ka khaldan habka difaaca jirka, wuxuuna keenaa barar natiijada. Marka la yaab ma leh, marka ay dadka qaba ADHD ka tijaabiyaan calaamadaha dhiigga ee caabuqa, waxay ogaadaan inay leeyihiin cytokines barar badan oo ka badan kantaroolka.

Marka aan eegno arrimaha korriinka ee ADHD, waxaan aragnaa nolosha hore ee soo-gaadhista khatarta deegaanka ee sababa caabuqa. Noocyada xayawaanka, waxay aqoonsadeen hababka u dhexeeya firfircoonida nidaamka difaaca inta lagu jiro uurka iyo maskaxda ku xigta iyo isbeddelka dabeecadda ee faraca la mid ah kuwa lagu arko dadka qaba ADHD.

Haddii intaas oo dhan aysan ku filneyn inay kugu qanciso in xanuunka neuroinflammation uu aad ugu habboon yahay ADHD, ii oggolow inaan kuu sheego polymorphism-yada hidde-sideyaasha ee ay heleen ee la xiriira waddooyinka abuura bararkaas.

Haddii dhammaan ururadan la ogaado inay sabab u yihiin iyo in kale, waxaan ku doodi karaa, waxba maaha. Si qumman uma hoos soconno habka sababa ee waxyaallaha intooda badan, waxaanan ku dul dharbaaxnaa dawooyinka si aan wax uga beddelno waxa aan u maleyneyno in ay socdaan, waanan sameynaa mar walba. Markaa maxaynu u tixgelin waynay caabuqa inuu yahay bartilmaameed suurtagal ah si loo yareeyo calaamadaha ADHD?

Nasiib wanaag, cilmi-baarayaal badan oo runtii caqli badan ayaa mar hore igu raacay. Ma rabo inaad u maleyso in tani ay tahay wax aan keligay la yimid.

Iyada oo ku saleysan mala-awaalkayaga, bartilmaameedka neuroinflammation wuxuu u adeegi karaa faragelin daweyn oo cusub oo suurtagal ah si loogu daweeyo ADHD

Kerekes, N., Sanchéz-Pérez, AM, & Landry, M. (2021). Neuroinflammation sida xiriirka suurtogalka ah ee u dhexeeya feejignaanta-deficit / xanuunka kacsanaanta (ADHD) iyo xanuunka. https://doi.org/10.1016/j.mehy.2021.110717

Xanuunkan neuroinflammation wuxuu sidoo kale khuseeyaa waxa aan ku akhrinay qaybta ugu dambeysa ee ku saabsan dheelitir la'aanta neurotransmitter. Caabuqa wuxuu abuuraa neurotransmitters badan oo kacsan wuxuuna kor u qaadaa xanaaqa aan ku aragno inta u dhaxaysa glutamate iyo GABA. Caabuqa wuxuu abuuraa jawi maskaxda ah halkaas oo aysan samayn karin saamiga ku habboon ee GABA ilaa glutamate. Waxay u badan tahay sababtoo ah waxay ku hoos jirtaa cadaadis (laga bilaabo dhammaan eryada baabuurta aan joogsiga lahayn).

Waa wax aan macquul ahayn in aad u malaynayso inaad samaynayso neurotransmitters oo kuu sheegaya inaad qaboojiso iyo in wax walbaa ay sax yihiin markaad qabtid xanuunka neerfaha ee joogtada ah. Tani waa sababta ay muhiim u tahay inaad fiiro gaar ah u yeelato calaamadahaaga. Waa dariiqa maskaxdaadu u sheegto wax aad u khaldan. Waxay u baahan tahay inaadan iska indho-tirin baabuurka aan joogsiga lahayn ee socda iyo waxyeelada. Waxay u baahan tahay inaad fiiro gaar ah u yeelato. Malaha maaha taageere adiga oo isku dayaya in aad hesho warqad dhakhtar kuu qoray oo kaa caawinaysa in aad iska dhigto in waxyeelladu aanay dhacayn.

Aan ka dhigno bararka mid ka mid ah bartilmaameedyada udub-dhexaadka ah ee faragelinta ee aan aragno ka qayb qaadashada calaamadaha ADHD/maskaxda ADD.

Sidee cuntooyinka ketogenic u yihiin daawaynta caabuqa neuroinflammation ee lagu arkay ADHD

Sida aan kor uga soo hadalnay, xanuunka neuroinflammation ee lagu arkay ADHD wuxuu ka yimaadaa qayb ka mid ah jawaabaha difaaca ee aan shaqaynayn. Caadi ahaan kama hadlo saameynta cuntooyinka ketogenic ee habka difaaca jirka, laakiin waxay u muuqataa inay aad ugu habboon tahay etiology iyo soo bandhigida calaamadaha dadkan.

Si kastaba ha ahaatee, si fiican looma baran habka difaaca jirka, markaa waxaan noqon doonaa mid guud halkan oo aan samayn doono baaritaan dheeraad ah haddii aad dareento baahida.

Cuntooyinka ketogenic waxay hagaajiyaan oo dheelitiraan shaqada difaaca. Waxaan u isticmaalnaa si ay u caawiyaan daawaynta noocyada kansarka qaarkood, qayb ahaan, sababtoo ah jawaab-celinta habboon ee difaaca ee firfircoonida unugyada T-cell. Cilmi-baarayaashu waxay heleen saameyn ku filan oo ku filan oo cunto ketogenic ah oo ku saabsan habka difaaca jirka taas oo RCT la bilaabay si loo arko haddii loo isticmaali karo in lagu bixiyo arrin ka hortag ah oo ka dhan ah COVID.

Dadka qaarkood waxay u maleynayaan in kor u kaca nidaamka difaaca uu dhaco sababtoo ah cuntada ketogenic ee isbeddelka microbiome-ka mindhicirka. Mid ka mid ah shidaalka uu jecel yahay mindhicirka waa butyrate, oo ka tirsan jirka ketone qaarkood waxaana laga heli karaa qaddarka ugu sarreeya ee subagga. Had iyo jeer waxaan u arkaa inay tani tahay mid aad u qurux badan, marka la eego diiradda ilaa hadda waxay u muuqataa inay dhammaan ku saabsan tahay fiber prebiotic sida geesiga ugu sarreeya caafimaadka mindhicirka iyo fayoobaanta. Waa inaan sidoo kale tilmaamaa in bogsashada qaar ay ku dhacdo xannibaadda dhiigga-maskaxda markaad tagto cunto ketogenic ah.

Markaa, saamaynta faa'iidada leh ee cuntada ketogenic waxay ku xirnaan kartaa kor u kaca qaadashada maskaxda ee KBs si loo waafajiyo baahida dheef-shiid kiimikaadka iyo hagaajinta BBB khalkhalka leh. Sida saamaynta KB-yada ee BBB iyo hababka gaadiidka ee BBB si fiican loo fahmay, waxa suurtogal noqon doonta in la sameeyo xeelado kale oo lagu wanaajiyo faa'iidooyinka daweynta ee KB-yada cilladaha maskaxda halkaasoo BBB la waxyeeleeyay.

(KBs=jidhka ketone; BBB=caqabad maskaxda dhiiga)
Banjara, M., & Janigro, D. (2016). Saamaynta cuntada ketogenic ku leedahay xannibaadda dhiigga-maskaxda. 
DOI: 10.1093/med/9780190497996.001.0001

Caqabadda maskaxda ee caafimaadka qabta waxay la macno tahay waxyaabo yar oo maskaxdaada ku sabbaynaya oo aan si dhab ah u lahayn. Oo markaad leedahay sun ama walxo ka soo mara xannibaadda dhiigga-maskaxda ee aan ka tirsanayn, waxay keenaysaa kicinta cytokines waxayna gacan ka geysataa caabuqa neuroinflammation.

Markaa ka fiirso saamaynta cuntada ketogenic ku leedahay shaqada difaaca sida gunno ka ciyaara door muhiim ah oo kaa caawinaysa yaraynta calaamadaha ADHD/ADD waxay kaa caawinayaan yaraynta calaamadahaaga.

Hab kale oo ay cuntooyinka ketogenic ku yareeyaan bararka waa iyadoo la joojinayo waddooyinka caabuqa. Ketones, oo laga sameeyay cuntooyin badan oo ketogenic ah, ayaa ah unugyo calaamadeynaya, iyo inay noqdaan unugyo calaamad ah waxay ka dhigan tahay inay u adeegaan sida fariinta, u sheegta qaar ka mid ah hiddo-wadaha inay damiyaan iyo kuwa kale inay shidaan. Cuntooyinka ketogenic waxay hoos u dhigaan bararka habkan aadka u qabow. Sida, si toos ah.

Qaybta soo socota, waxaan ku baran doonaa sida caabuqu uu door uga qaato diiqada oksaydhka iyo sida hoos u dhaca habkan cudurada u saameeya calaamadaha aan ku aragno ADHD.

ADHD iyo Cadaadiska Oxidative

Cadaadiska Oxidative waxa uu yimaadaa marka ay jirto dheellitir la'aanta awoodda jidhku u leeyahay in uu wax ka qabto waxyaabaha ka soo baxa ee ku dhaca uun noolaanshaha. Waxyaabo badan ayaa keeni kara stress ok. Neefsashada kaliya waxay abuurtaa shay loo yaqaan noocyada ogsijiinta falcelinta (ROS). Markaa jidhkaagu waxa uu rajaynayaa qadar go'an oo ROS ah, in aad noolaato. Dhibaatona maaha marka waxyeelada/nidaamka antioxidant-ku ay isku dheeli tiran yihiin. Sida aan uga hadli doono dambe ee boostada blog, waxaa naloo sameeyay si aan ula macaamilno ROS, ugu yaraan ilaa xad. Laakiin heerarka aan maanta daaha ka qaaday waa kuwo aan horay loo arag taariikhdaada kobcinta.

Waxaan ka wada hadalnay caabuq. Bararka ma sameeyaa cadaadis oksaydhyo badan? Haa Haa, runtii way sameyneysaa.

Habka bararku wuxuu keenaa diiqada oksaydhka wuxuuna yareeyaa awoodda antioxidant-ka gacanta.

Khansari, N., Shakiba, Y., & Mahmoudi, M. (2009). Caabuqa joogtada ah iyo walbahaarka oksaydhiyaha oo ah sababta ugu weyn ee cudurrada da'da la xiriira iyo kansarka. https://doi.org/10.2174/187221309787158371

ROS-kan waa in la nadiifiyaa ama la dhex dhexaadiyaa. Jirkaagu si uu taas u sameeyo, waxaad u baahan tahay nafaqeeyayaal badan oo yar yar (cofactors) iyo heer wanaagsan oo ah labadaba endogenous (gudaha jidhkaaga lagu sameeyo) antioxidants. Dadku sidoo kale waxay isticmaalaan antioxidants (tusaale, turmeric, quercetin, fiitamiinada C iyo E), iyagoo isku dayaya inay yareeyaan diiqada oksaydhka.

Cadaadiska Oxidative ma aha kaftan. La oggolaaday in uu socdo iyada oo aan la hubin wakhti ka dib, waxa aad dhaawac gaadhaysaa DNA-gaaga. Aan dib ugu noqonno isbarbardhigga gaadhigayaga. Waxaad mooddaa in baabuurka baabuurka uu faraha ka baxay oo dhismayaal dumay, waddooyinkuna burbursan yihiin. Laakiin hadda, aqoontii lagu hagaajin lahaa arrimahaas oo dhan waxay ku luntay dhammaan fowdo. Oo hadda dadka isku dayaya inay dib u dhisaan magaalada, ka dib dhammaan baabuurtaas, ma samayn karaan si sax ah ama si deggan. Tani waxay u dhigantaa dhaawaca DNA-ga ee ku dhaca diiqada oksaydhka ee aan la xakamayn. Sida aad qiyaasi karto, cudurro dabadheeraad ah ayaa ka dhalan doona natiijada tan.

Waxaa jira siyaabo badan oo kala duwan oo ROS badan loo abuuray marka loo eego waxa jidhkeenu xamili karo. Ka sokow neefsashada iyo dheef-shiid kiimikaadka tamarta, qaar ka mid ah waxyaabaha kordhin kara culeyska cadaadiska oksaydhka ee deegaanka waxaa ka mid ah:

  • UV iyo shucaaca ionizing
  • wasakhaysan
  • macdanaha culus
  • ka kooban dhirta
  • daroogada
  • sunta cayayaanka
  • isku qurxiyo
  • dhadhanka
  • uunsi
  • cuntada lagu daro
  • kiimikada warshadaha
  • wasakheynta deegaanka

Dhammaan kuwan waxay si weyn u kordhiyaan ROS waxayna sababaan isku dheelitir la'aantan aan u tixraacno cadaadiska oksaydhka. Cadaadiska Oxidative wuxuu keenaa dhaawaca unugyada iyo unugyada, iyo maskaxda, guud ahaan, ayaa si gaar ah ugu nugul.

Laakiin ADHD/ADD maskaxda ayaa aad uga sii badan. Maya, runtii, waxayna ku jirtaa suugaanta cilmi-baadhista. Laakin inta aynaan taa ka hadlin, aan ka hadalno daawooyinka loo isticmaalo daawaynta ADHD.

Dhammaan ilaha deegaanka ee cadaadiska oksaydhiyeyaasha ee kor lagu soo sheegay, dawooyinka dadku si ay u daaweeyaan calaamadaha ADHD waxay uga sii dari karaan dhibaatada. Isticmaalka daawooyinka ADHD sida Methylphenidate (MPH), oo loo iibiyo sida Ritalin iyo magacyo kale, waxay kordhisaa heerarka cadaadiska oksaydhka.

Gudaha MPH waxaa jira cadaymo kordhinta OS, difaaca AO oo bedelay iyo bararka neerfaha ee carruurta ADHD

Kovacic, P., & Weston, W. Feejignaanta-deficit / xanuunka kacsanaanta-habka mideeya ee ku lug leh daaweynta antioxidant: Phenolics, noocyada oksijiinta falcelinta, iyo walbahaarka oksida. https://www.biochemjournal.com/articles/23/1-2-10-853.pdf

Suugaanta cilmi-baarista, waxaan ku aragnaa heerarka sare ee cadaadiska oksaydhka ee maskaxda ADHD, tanina waxay ka iman kartaa nuglaanshaha hidde-sidaha gaarka ah ee ROS.

Mid ka mid ah tusaale ahaan tan waa Organophosphates, sida dimethyl phosphate (DMP; sunta cayayaanka). Daraasadaha hidde-sidaha ayaa muujiyay in la kulmay heerarka sare ee walaxdan ee deegaanka ay abuurtay khatar aad u sareysa oo lagu horumarinayo qaar ka mid ah isbeddellada saxda ah ee aan ku aragno ADHD oo leh dopamine reseptors.

59% kiisaska ADHD ee carruurta ay soo bandhigtay DMP ee qaba cudurka DRD4 GG genotype waxaa sabab u ahaa isdhexgalka hiddo-wadaha deegaanka. Ka dib hagaajinta covariates kale, carruurta qaaday DRD4 GG genotype, waxa uu la kulmay heerar sare oo DMP ah (in ka badan dhexdhexaadiyaha), waxana uu lahaa … khatar aad u korodhay oo lagu horumarinayo ADHD

Chang, CH, iyo al., (2018). Isdhexgalka ka dhexeeya soo-gaadhista sunta cayayaanka ee organophosphate, walbahaarka oksaydhka, iyo polymorphisms-ka hidde-sideyaasha dopamine reseptor D4 waxay kordhiyaan khatarta feejignaanta yaraanta/dhibanaanta firfircoonida carruurta. https://doi.org/10.1016/j.envres.2017.10.011

Markaa cadaadiska oksaydhiyuhu waxa laga yaabaa inuu si fiican qayb uga noqdo etiology (sida uu ku bilaabmayo) ee ADHD. Laakiin door miyay ka ciyaartaa dayactirkeeda? Waxaan dhihi lahaa haa Waxa jira polymorphisms hiddo-wadaha la xidhiidha caabuqa ee lagu arko kuwa qaba ADHD. Heerarka antioxidant-ka ee la dhimay ayaa lagu arkaa carruurta, dhalinyarada, iyo dadka waaweyn marka loo eego kooxaha kantaroolka.

Cadaadiska Oxidative waa arrin ku jirta maskaxda ADHD/ADD mid ka mid ah daawaynta aad loo jecel yahay oo la sheegay in ay tahay isticmaalka OPC-yada. OPC-yadu waxay si gaar ah u yihiin antioxidants awood leh. Marka hore waxaan iyaga ku bartay webinaarka bilaashka ah ee Cilmi-nafsiga Redefined, oo aad daawan karto halkan. Ma doonayo in aan mawduuca ka baxo, markaa geli maayo OPC-yada boostada blog-ka. Waxaad wax badan oo iyaga ku saabsan ka baran kartaa halkan:

OPC-yadu ma yihiin ikhtiyaar lagu daweyn karo niyad-jabka daawo la'aan?

Laakin waxaan rabay in aan tilmaamo in cadaadiska oksaydhative-ku yahay bartilmaameedka daawaynta ee maskaxda shaqaynaysa. Waxaa laga yaabaa inaadan ka helin faa'iidada dhakhtar kuu qoray oo loo tababaray daawa shaqaynaysa. Markaa macluumaadkan halkan ayaan kaga tagay haddii aad rabto inaad wax badan u sahamiso safarkaaga fayoobida.

Laakiin sida aan u baran doonno, waxaa jira siyaabo badan oo cuntada ketogenic ay ka caawiso daawaynta diiqada oksaydhka, taas oo suurtogal ah (iyo laga yaabo) inay hagaajiso calaamadahaaga. Hal hab oo kale oo keto uu ku caawin karo ADHD.

Sidee cuntooyinka ketogenic u yareeyaan heerarka walbahaarka oksaydhka ee dadka qaba ADHD

Waxaa jira wadooyin badan oo ay saameeyaan cuntooyinka ketogenic. Hal tusaale ayaa ah in uu jiro koror agmatine, neurotransmitter ka yar oo caan ah oo laga sameeyay amino acid L-arginine. Kordhinta agmatine ee maskaxda ee ku dhacda cuntada ketogenic waxay leedahay sifooyin neuroprotective oo si fiican loo diiwaangeliyay kuwaas oo ka caawiya ilaalinta maskaxda ADHD heerarka korodhka cadaadiska oksaydhka.

Waxyaabo kale oo aad ka ogaan karto cuntooyinka ketogenic, ee ku saabsan saamaynta ay ku leeyihiin diiqada oksaydhka, ayaa ah in ketones ay yihiin ilo tamar aad u nadiif ah. ROS ka yar ayaa u abuurtay ketones gubanaya shidaalka marka loo eego ilaha kale ee aasaasiga ah. Sababtaas awgeed, βHB (nooc ka mid ah jirka ketone) waxay hoos u dhigtaa wax soo saarka ROS waxayna kordhisaa difaacyada antioxidant.

Habka kale ee cuntada ketogenic ay si toos ah uga caawiso daaweynta cadaadiska oksaydhisku waa in βHB ay yareyso dhaawaca oksaydhka sababtoo ah cayda excitotoxic (tusaale, xasuuso glutamate?) Goobta uu burburku ka dhaco. Si kastaba ha ahaatee βHB waxay caawisaa inay qoyaan ama dib u hagaajiso waxyeelada ay keento diiqada oksaydhka. Cilmi-baarayaashuna waxay u maleynayaan in tani ay sabab u tahay shaqada mitochondrial ee la hagaajiyay ama saameyn ku yeelashada muujinta hidda-socodka.

Laakiin sug, waxaa jira xitaa in ka badan in cuntada ketogenic ay sameyso si ay uga caawiso dhimista cadaadiska oksaydhka.

Cuntooyinka ketogenic waxay naga caawiyaan inaan samayno wax badan oo ka mid ah antioxidant-ka muhiimka ah ee aan ku samayno jirkeena. Xusuusnow, waxaan ka hadalnay sida jirkaagu u ogaado in ROS ay noqon doonto wax. Sababtoo ah waxaad neefsataa oo cuntaa oo dhaqaaqdaa iyo alaab. Markaa sida iska cad, waxay leedahay hab ay taas wax uga qabato. Waxayna la macaamilaysaa heerkaas caadiga ah ee ROS shay la yiraahdo Glutathione. Laakiin sidii aan barannay, waxaa jira arrimo badan oo deegaankeena ah oo riixaya ROS-da heerarkii la filayay.

Glutathione waa antioxidant muhiim ah oo ka ilaalin karta unugyada waxyeelada DNA-da. Cuntooyinka ketogenic waxay kaa caawinayaan inaad sameysid glutathione badan adoo kordhinaya GCL, enzyme loo baahan yahay si loo soo saaro Glutathione. GCL waxaa loo tixgeliyaa "heerka xaddida enzyme," taasoo la macno ah in aad hesho glutathione oo kaliya inta aad leedahay enzimkaas. Markaa, cuntada ketogenic ee samaynta GCL badan ayaa ah waxa ku siinaya glutathione badan waana xulafo aad u awood badan si loo yareeyo diiqada oksaydhka ee maskaxda ADHD.

Ugu Dambeyn

Markaa halkaas ayaad haysataa. Kuwani waa qaar ka mid ah siyaabaha badan ee cuntada ketogenic ay kaa caawin karto yaraynta calaamadaha ADHD iyo ADD. Sida aad arki karto, cuntada ketogenic waa faragelin dhinacyo badan leh.

Waxay wanaajisaa caafimaadka xuubka unugyada neerfaha, hagaajinta xiriirka ka dhexeeya unugyada. Cuntooyinka Ketogenic waxay hagaajiyaan GABA, iyagoo gacan ka geysanaya hagaajinta dheellitirka glutamate/GABA ee lagu arkay dadkan.

Ketones-ku waxay hagaajiyaan (wax badan ka sameeyaan) factor neurotrophic maskaxda (BDNF) si ay u sameeyaan dayactirka unugyada neuronal. Xusuusnow, kuwa qaata dopamine-ka isma hagaajiyaan. Laakiin laga yaabee in ka sii badan oo la xidhiidha sida kor u qaadida BDNF ay suurtogal u tahay inay wanaajiso xusuusta shaqada iyo barashada kuwa qaba ADHD.

Cuntooyinka ketogenic halkaas kuma eka.

Waxay yareeyaan xanuunka neuroinflammation waxayna yihiin neuroprotective, taas oo yareyn doonta cadaadiska oksaydhka ee maskaxda ADHD.

Cuntooyinka ketogenic waxay hagaajiyaan shaqada mitochondrial waxayna u abuuraan il tamar aad u fiican qaybaha maskaxda ee ah hypometabolic. Tani waxay soo saartaa tamarta la hagaajiyay waxay dejinaysaa xuubka neerfaha (xusuusnow hyperpolarization?) Waxay u ogolaataa unugyada inay si fiican u shaqeeyaan. Waxaa suurtogal ah in aad faa'iido u leh kala duwanaanshaha muujinta ee serotonin iyo dopamine reseptors iyo gaadiidleyda lagu arko kuwa qaba ADHD iyo ADD.

Kuwani waa dhammaan meelaha bogsashada suurtagalka ah ee ku lug leh calaamadaha ADHD.

Laakiin sug, waxaa laga yaabaa inaad tiraahdo. Kaliya ma qabo ADHD ama ADD. Waxaan qabaa arrimo isku dhafan, sida cilladaha niyadda iyo dhibaatooyinka isticmaalka mukhaadaraadka. Tani ima yaabin. Marka shaqada fulinta ay daciifto, sabab kasta ha ahaatee, dadku waxay dhib kala kulmaan nidaaminta niyadda. Waxaad u baahan tahay xudunta hore oo si buuxda u shaqaynaysa iyo dheelitirka neurotransmitter si aad u xakamayso shucuurtaada. Iyo sababta oo ah cuntooyinka ketogenic waxay kaa caawinayaan shay noocaas oo kale ah, waa inaysan ku yaabin inaan haysto qoraallo kala duwan oo ka hadlaya sida cuntooyinka ketogenic ay sidoo kale u caawiyaan daweynta walaaca, niyad-jabka, iyo khalkhalka isticmaalka maandooriyaha.

Sidee bay cuntooyinka ketogenic u caawiyaan xanuunka welwelka?
Cuntada Ketogenic waxay daaweysaa khamriga
Keto ma daweyn karaa niyad-jabkayga daawo la'aan?

Iyadoo heerka daryeelka ay tahay in had iyo jeer laguu soo bandhigo, waxa kale oo muhiim kuu ah inaad ogaato doorashooyin kale oo waliba caddayn ku salaysan. Markaa waxaad samayn kartaa go'aano xog ogaal ah oo ku saabsan daryeelkooda.

Sababtoo ah waxaad xaq u leedahay inaad ogaato dhammaan siyaabaha aad ku dareemi karto fiicnaan.

Cuntada ketogenic waa mid ka mid ah. Waxaana muhiim ii ah in qof uu kula soo xidhiidho si aad u gaadho go'aano xog ogaal ah oo ku saabsan daawayntaada.

Waxaan rabaa inaan kugu dhiirigeliyo inaad wax badan ka barato doorashooyinkaaga daawaynta mid kasta oo aan ahay posts blog. Waxaan wax ka qoraa habab kala duwan oo tafatiran heerar kala duwan ah oo laga yaabo inaad ku caawiso inaad wax ka barato safarkaaga fayoobida.

La wadaag qoraalkan baloogga ah ama kuwa kale asxaabta iyo qoyska la ildaran calaamadaha. Dadku ha ogaadaan inay rajo jirto.

Wax badan oo aniga igu saabsan ayaad baran kartaa halkan. Haddii aad jeclaan lahayd inaad ila shaqeyso si aan gacan uga geysto u gudubkaaga cuntada ketogenic, waxaad sidaas ku sameyn kartaa barnaamijka khadka tooska ah ee aan bixiyo.

Barnaamijka Soo kabashada Ceerfaha Maskaxda

Anigu, sida had iyo jeer, aad ayaan ugu faraxsanahay rajada ah inaad fiicnaan karto.

Ma jeceshahay waxa aad ka akhrinayso blog-ka? Ma doonaysaa inaad wax ka barato webinars-ka soo socda, koorsooyinka, iyo xataa waxay bixisaa taageero iyo ila shaqaynta ujeedooyinka caafimaadkaaga? Hoos iska diiwaan geli oo soo deji Hagahaaga Nafaqada Maskaxda ee bilaashka ah.

Tilmaamaha Nafaqada Maskaxda ee Bilaashka ah

tixraacyada

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